Searchable abstracts of presentations at key conferences in endocrinology

ea0063p723 | Pituitary and Neuroendocrinology 2 | ECE2019

Elevated Chromogranin A levels in a patient with acromegaly – who is the culprit?

Mitrache Marius-Lucian , Leca Bianca , Martin Sorina , Fica Simona

Background: Chromogranin A (CgA) belongs to the family of granins, proteins which are an integral part of the secretory granules of neuroendocrine cells in endocrine glands and the diffuse neuroendocrine system. While it has become standard clinical practice to measure serum CgA in neuroendocrine tumors, various other non-endocrine conditions may increase this marker’s concentration and lead to diagnostic problems.Case report: We present the case of...

ea0049ep143 | Clinical case reports - Thyroid/Others | ECE2017

MEN 1 Syndrome- a case with recurrence of neuroendocrine tumor and hyperparathyroidism after 9 years of follow up

Leca Bianca Maria , Gherasim Iustina , Sava Elisabeta , Martin Sorina , Florea Suzana , Fica Simona

Introduction: Life expectancy is decreased in MEN1 patients due to multiple tumors that may be larger, more aggressive, resistant to treatment and with a higher risk of recurrence.Case report: We report a 59-year-old male patient with family history of endocrine tumors (father- pituitary adenoma, son- primary hyperparathyroidism, daughter- microprolactinoma, primary hyperparathyroidism). He was first referred to our Clinic in 2007 after being incidendall...

ea0049ep855 | Clinical case reports - Pituitary/Adrenal | ECE2017

A case of pituitary apoplexy in a patient with Cushing’s disease due to corticotroph macroadenoma

Sava Elisabeta , Leca Bianca , Sirbu Anca , Georgescu Olivia , Cima Luminita , Florea Suzana , Fica Simona

Corticotroph macroadenomas are exceptionally found in Cushing’s disease. Pituitary apoplexy is a rare endocrine emergency condition caused by either hemorrhage or infarction of the pituitary gland. We report a case of a 56-year-old female diagnosed with type 2 diabetes in 2008. One year after, at the periodical follow up, she presented with uncontrolled diabetes (HbA1c=12.26%) and clinical manifestations suggestive for hypercortisolism, therefore insulin therapy was initi...

ea0056p575 | Obesity | ECE2018

The effect of laparoscopic sleeve gastrectomy on kidney function

Leca Bianca , Sava Elisabeta , Soare Iulia , Martin Sorina , Smeu Bogdan , Copaescu Catalin , Sirbu Anca , Fica Simona

Introduction: Higher body mass index (BMI) has been associated with adverse renal outcomes, including chronic kidney disease (CKD), progression to end-stage renal disease (ESRD), nephrolithiasis and renal cell cancer. Several studies have shown that weight loss following bariatric surgery has a positive effect on kidney function, mediated by a reduction in proteinuria, glomerular hyperfiltration and improvements in blood pressure and insulin resistance. The aim of this study w...

ea0056p577 | Obesity | ECE2018

Weight loss and metabolic parameters after laparoscopic sleeve gastrectomy

Sava Elisabeta , Leca Bianca , Sirbu Anca , Soare Iulia , Martin Sorina , Smeu Bogdan , Copaescu Catalin , Fica Simona

Introduction: Obesity, defined as a BMI ≥30 kg/m2, is the most common chronic metabolic disease in the world and its prevalence has strongly increased. Obesity is associated with multiple comorbidities, including cardiovascular disease, hypertension, insulin resistance, dyslipidemia, type 2 diabetes, sleep apnea and certain cancers. Bariatric surgery is the most effective treatment for severe obesity and produces dramatic and durable weight loss. The ...

ea0069oc2 | Oral Communications | SFENCC2020

Paraneoplastic hypoglycaemia secondary to IGF-2 secretion from a metastatic gastrointestinal stromal tumour

Onyema Michael , Drakou Eftychia , Giovos Georgios , Leca Bianca , Ganguly Ratnadeep , Murthy Narasimha , Grossman Ashley , Randeva Harpal , Dimitriadis Georgios

Case history: Herein, we report the case of a 79-year-old male who presented acutely to A&E with recurrent episodes of symptomatic hypoglycaemia. A random glucose at presentation was low at 1.4 mmol/l and upon correction symptoms resolved. While hospitalized, he continued having episodes of symptomatic hypoglycaemia, requiring treatment with intravenous dextrose and per os steroids. Once stable, he was discharged with advice.Investigations: ...

ea0065p239 | Metabolism and Obesity | SFEBES2019

Weight loss and change in obesity related comorbidities in patients undergoing laparoscopic adjustable gastric banding at UHCW between 2009 and 2012

Leca Bianca , Dimitriadis Georgios K , Khan Uzma , Abraham Jenny , Halder Louise , Shuttlewood Emma , Shah Neha , Barber Thomas M , Menon Vinod , Randeva Harpal S

Background: The Royal College of Physicians (RCP) called earlier this year for obesity to urgently be recognized as a disease, and warned that until this happens its prevalence is unlikely to be reduced. Obesity is associated with multiple comorbidities, including type 2 diabetes mellitus (T2DM), hypertension (HT), and dyslipidemia. Bariatric surgery (BS) produces dramatic weight loss, with improvement of obesity associated comorbidities and decrease of overall mortality.<...

ea0070aep374 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Liraglutide downregulates the expression of miRNA-424 in patients with obesity

Dimitriadis Georgios K , Dimitri Federica , Bate Danielle , Leca Bianca , Davasgaium Allan , Tripathi Gyanendra , Miras Alexander D , Rubino Francesco , Christian Mark , Randeva Harpal S

Aims: Liraglutide 3 mg once daily is an approved, prescription injectable Glucagon Like Peptide-1 receptor agonist that, when used with a low-calorie diet and increased physical activity, can reduce excess weight in patients with obesity. MiRNAs are small non-coding single stranded RNAs that regulate gene expression post-transcriptionally by inhibiting their mRNA target translation into proteins. MiRNAs can be secreted in the blood stream and affect the molecular pathways...

ea0056gp188 | Pituitary / Growth Hormone ' IGF Axis | ECE2018

Growth disorders in paediatric survivors of hematopoietic stem cell transplantation after chemotherapy-only conditioning- the experience of a single center

Cima Luminita-Nicoleta , Lambrescu Ioana Maria , Nedelea Lavinia , Sava Elisabeta , Leca Bianca , Vadana Elena-Alexandra , Colita Anca , Barbu Carmen Gabriela , Fica Simona

Objective: The reported incidence of growth disorders in hematopoietic stem cell transplantation (HSCT) recipients ranges from 20 to 80% and it was usually described in patients that were given total body irradiation (TBI) in the conditioning regimen. Because the effect of chemotherapy-only conditioning is less clear, we investigated the frequency of growth failure in our series of children treated with HSCT for different disorders without TBI as part of the conditioning proto...