Searchable abstracts of presentations at key conferences in endocrinology

ea0014p521 | (1) | ECE2007

Somatic, body composition and psychological particularities in a group of untreated adult pituitary dwarves

Gotca Ioan , Branisteanu Dumitru , Leustean Letitia , Zbranca Eusebie , Mogos Voichita

Aside its growth promoting effects, growth hormone (GH) displays other actions upon carbohydrate, lipid and protein metabolisms, and possibly also direct central nervous system effects. Fourteen adult pituitary dwarves (mean height of 132.3±8 cm, mean age of 30.7±9.6 y), 5 women and 9 men, never having received rGH therapy, were investigated. Body composition (BC) was assessed by bioelectrical impedance, and bone mineral density (BMD) was evaluated by quantitative ul...

ea0014p591 | (1) | ECE2007

Self-concept in patients with PCOS

Gotca Ioan , Cristea Cristina , Leustean Letitia , Ioana Draghici , Zbranca Eusebie

Polycystic ovary syndrome (PCOS) is a major source of psychological morbidity and can negatively affect quality of life. The aim of the study was to identify characteristics of self-concept in female patients diagnosed with PCOS (n=22, mean age 26+/− 11 years) and comparative analysis with a control group (n=22).Methods: Psychology questionnaire, selection tests based on geometrical figures/ words and also graph logical analysis were ...

ea0081ep712 | Pituitary and Neuroendocrinology | ECE2022

Evolution from recurrent cushing’s disease to pituitary carcinoma

Anisia Miruna , Dumitru Teodora , Stoica Alexandra , Ungureanu Maria Christina , Preda Cristina , Rotariu Daniel , Leustean Letitia

Introduction: ACTH-secreting pituitary adenomas occasionally present as aggressive pituitary tumors (APT), with invasion of surrounding structures, rapid growth, resistance to conventional therapies and multiple recurrences. In rare cases they can progress to pituitary carcinomas (PC) in several years, diagnosis being made upon the documentation of systemic or central nervous system (CNS) metastatic spread. Among pituitary carcinomas, the most common malignant subtypes are lac...

ea0081ep753 | Pituitary and Neuroendocrinology | ECE2022

Acromegaly: a rare disease with multiple, complex complications

Istrate Andra Cristiana , Leustean Letitia , Ungureanu Maria- Christina , Teodoriu Laura , Bilha Stefana , Florescu Alexandru , Preda Cristina

Introduction: Acromegaly is a rare, challenging disease that if not appropriately treated can lead to numerous complications. Some of the most frequent complications are cardiovascular (hypertension, secondary cardiomyopathy, arrhythmias, valvulopathies, heart failure) and metabolic (secondary diabetes, various alterations of the lipid metabolisms). Aim: The aim is to asses the impact of long-term acromegaly on the cardiovascular system and glucide and l...

ea0063ep151 | Thyroid | ECE2019

Multicentric papillary thyroid carcinoma with concomitant rare dedifferentiation in the lymph node metastasis

Ciobotar Mihaela , Teusan Teodora , Preda Cristina , Ciobanu Delia , Piciu Doina , Leustean Letitia

Introduction: Papillary thyroid carcinoma (PTC) is a differentiated thyroid carcinoma accounting for approximately 80% of all thyroid malignancies; in contrast only 1–2% of thyroid cancers are anaplastic. While the transformation of papillary thyroid carcinoma to the more aggressive anaplastic carcinoma represents a well known occurrence, the transformation of metastatic PTC in a distant location is an uncommon finding, but new insights from the BRAF(V600E) mutat...

ea0037ep111 | Steroids, development and paediatric endocrinology | ECE2015

The beast behind the dwarf

Rimbu Cosmina , Damian Lisandra , Leustean Letitia , Miron Ingrith , Florescu Alexandru , Vulpoi Carmen , Ungureanu Maria Christina

Abnormalities of growth are one of the most common reasons for the paediatric–endocrinology consults. It’s an obvious manifestation with countless possible causes behind, and sometimes we can have unexpected diagnosis.Case presentation: we investigated the case of a 4 years old girl, born at term, naturally, SGA: birth weight=1950 g, who presented in the Endocrinology Department for short stature. Clinical evaluation: 89.5 cm (−4 DS), 11 ...

ea0032p607 | Female reproduction | ECE2013

Main determinants of serum uric acid concentrations in polycystic ovary syndrome patients

Leustean Letitia , Preda Cristina , Ungureanu Maria Christina , Cristea Cristina , Mogos Voichita , Ungureanu Didona , Vulpoi Carmen

Introduction: Uric acid may increase cardiovascular risk, exerting proinflammatory, pro-oxidant and proliferative actions at the endothelial cell level. Classic and non-classic cardiovascular risk markers cluster in women with polycystic ovary syndrome (PCOS), uric acid being proposed as one of them. The studies available at present regarding serum uric acid levels in PCOS patients are scarce and controversial. The aim of the study was to examine the relationship between uric ...

ea0014p470 | (1) | ECE2007

Thyrotoxic hypokalemic periodic paralysis in two Caucasian females

Preda Cristina , Leustean Letitia , Vulpoi Carmen , Cristea Cristina , Ungureanu Christina , Zbranca Eusebie

Hypokalemic periodic paralysis is an uncommon complication of thyrotoxicosis especially in Caucasian women. It is most frequent in east asian and Japanese males and is characterized by recurrent episodes of motor weekness of variable intensity associated with hyperthyroidism. It is usually associated with low plasma potassium levels and is often precipitated by physical activity. This condition is a self limiting disorder that is cured by the treatment of the underlying hypert...

ea0014p477 | (1) | ECE2007

Thyroid dysplasia – 30 cases of lingual thyroids

Zbranca Eusebie , Preda Cristina , Mogos Voichita , Leustean Letitia , Vulpoi Carmen , Galusca Bogdan , Rusu Valeriu , Negru Radu

Thyroid dysplasia (ectopy, hypoplasia or aplasia) is a common cause of congenital hypothyroidism. Lingual thyroid is a rare embryological aberration caused by failure of migration of the thyroid gland to its normal position in the neck.This retrospective study involved 30 patients with lingual thyroid diagnosed in our Department between 1970–2005. The diagnosis was based on physical examination, evaluation of the mental development (IQ) and following tests:TSH, fT4, ultra...

ea0014p500 | (1) | ECE2007

Short stature and neurofibromatosis type 1 – issues of diagnosis

Leustean Letitia , Hurjui Cristina , Preda Cristina , Vulpoi Carmen , Moisii Liliana , Zbranca Eusebie

Neurofibromatosis type 1 (NF1) is an inherited disorder characterized by formation of neurofibromas in the skin, brain and other parts of the body, in association with skin pigment changes. It is well known that this condition may be a risk factor for short stature with growth hormone deficiency (GHD) in children, due to suprasellar lesions. We present the case report of a 9-year-old boy admitted in our Service for short stature (-2DS). Physical examination revealed ‘caf&...