Searchable abstracts of presentations at key conferences in endocrinology

ea0081p75 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Type 1 diabetes technology and quality of life: glucose control and beyond

Irina Briganti Silvia , Maggi Daria , Strollo Rocky , Kyanvash Shadi , Lanza Oreste , Pozzilli Paolo , Manfrini Silvia

Background: Technological advances in continuous glucose monitoring (CGM) and continuous subcutaneous insulin infusion (CSII) should aim to improve glucose control and quality of life in patients diagnosed type 1 diabetes (T1D).Aim: The aim of our study was to compare different CGM and CSII devices on these targets.Methods: Sixty-nine T1D patients (mean age 39±12; 31 males) were recruited. 36 were on multiple daily insulin inj...

ea0081p321 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Effect of a novel-app based strategy for carbohydrate counting on glucose control in type 1 diabetes

Briganti Silvia Irina , Strollo Rocky , Maggi Daria , Kyanvash Shadi , Lanza Oreste , Manfrini Silvia , Pozzilli Paolo

Background: carbohydrate counting is often performed inaccurately by patients with type 1 diabetes (T1D). We hypothesized that mobile App ‘Dietrometro’, that estimates CHO content of food figures, would ameliorate glucose control.Aim: To study the effect of ‘Dietometro’ on glucose control.Methods: 54 T1D subjects (aged 18-60 years, 26 males), on multiple daily injections (n=23) or continuous subcutaneou...

ea0081p337 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Roux-en-Y gastric bypass and vertical sleeve gastrectomy showed similar efficacy in achieving cardiometabolic composite target in subject with type 2 diabetes undergoing bariatric surgery

Monte Lavinia , Tuccinardi Dario , Rossini Giovanni , Watanabe Mikiko , Pozzilli Paolo , Napoli Nicola , Manfrini Silvia

Introduction: The American Diabetes Association (ADA) produced a triple composite outcome that summarizes the therapeutic targets of the three most prevalent complications of obesity: type 2 diabetes (T2D), hypertension and dyslipidemia (HbA1c <7.0%; LDL cholesterol<100 mg/dl and systolic blood pressure <130 mmHg). The present study primarily investigates the difference between VSG and RYGB in achieving the composite target one year after the surgery. The secondary...

ea0081ep191 | Calcium and Bone | ECE2022

Primary hyperparathyroidism in the setting of previous roux-en-Y gastric bypass: a case report

Monte Lavinia , Tuccinardi Dario , Strollo Rocky , Briganti Silvia , Rausa Donatella , Pozzilli Paolo , Napoli Nicola , Manfrini Silvia

Introduction: Primary hyperparathyroidism (PHPT) after roux-en-Y gastric bypass (RYGB) is poorly described. The diagnosis can be difficult as secondary hyperparathyroidism(SHPT) commonly occurs in patients after RYGB due to calcium hypoabsorption and vitamin D deficiency.Observation: We present the case of a 50-year-old female with a history of normocalcemic hyperparathyroidism and nephrolithiasis. In 2005 the patient had undergone RYGB. During the first...

ea0081ep1049 | Thyroid | ECE2022

Worsening dysphagia and dysphonia: a case report

Rausa Donatella , Briganti Silvia Irina , Rossini Giovanni , Monte Lavinia , Napoli Nicola , Manfrini Silvia

Premise: multinodular goiter and compressive symptoms in the neck could not be necessarily associated.Case-report: A 82-year-old woman diagnosed follicular lymphoma in 2017 reached to the Emergency Department in Agoust 2021 because of a progressive and worsening dysphagia and dysphonia, begun six weeks before. The patient complained a weight loss of about 8 kg due to the inability in feeding. Her medical history was relevant for thyroid goiter, known sin...

ea0081ep588 | Endocrine-Related Cancer | ECE2022

Severe refractory nonislet cell tumor hypoglycemia and paraneoplastic hypercalcemia in a patient with pancreatic adenocarcinoma with neuroendocrine differentiation: a case report.

Rossini Giovanni , Tommaso Alfonso Maria Di , Rausa Donatella , Palermo Andrea , Tuccinardi Dario , Pozzilli Paolo , Napoli Nicola , Manfrini Silvia

Nonislet cell tumor hypoglycemia (NICTH) is a rare complication of malignancy characterized by overproduction of incompletely processed IGF-2 and subsequent stimulation of insulin receptors and increased glucose utilization. We report a patient with pancreatic adenocarcinoma with neuroendocrine differentiation who presented with NICTH and paraneoplastic hypercalcemia. A 51 year-old male was admitted to the ER for altered mental status and confusion. His blood glucose was 27 mg...

ea0073aep627 | Thyroid | ECE2021

Laser ablation versus radiofrequency ablation for benign non-functioning thyroid nodules: twelve-month results of a randomized, parallel-arm, open-label trial

Cesareo Roberto , Manfrini Silvia , Pasqualini Valerio , Ambrogi Cesare , Sanson Gianfranco , Gallo Andrea , Pozzilli Paolo , Pedone Claudio , Crescenzi Anna , Palermo Andrea

BackgroundRadiofrequency ablation (RFA) seems to achieve a significantly larger nodule volume reduction rate (VRR) than laser ablation (LA) in benign non-functioning thyroid nodules (BNTNs). We compared the efficacy and safety of both thermal ablation treatments at the 12-month follow-up in patients with solid or predominantly solid BNTN.MethodsThis 12-month, single-use, randomized open-label parallel trial c...

ea0070oc7.6 | Endocrine-related Cancer | ECE2020

Llaser ablation vs radiofrequency ablation for benign non-functioning thyroid nodules: six-month results of a randomised, parallel, open-label, trial (LARA trial)

Cesareo Roberto , Maurizio Pacella Claudio , Pasqualini Valerio , Campagna Giuseppe , Lauria Pantano Angelo , Pozzilli Paolo , Cianni Roberto , Manfrini Silvia , Crescenzi Anna , Palermo Andrea

Background: No direct prospective studies comparing laser ablation (LA) and radiofrequency ablation (RFA) for debulking benign non-functioning thyroid nodules (BNTNs) exist. We aimed to compare the efficacy and safety of both techniques in patients with solid or predominantly solid BNTN.Methods: This six-month, single-use, randomized open label parallel trial compared the following primary endpoints between the RFA and LA groups six months after treatmen...

ea0056gp265 | Thyroid non cancer - Benign Thyroid disease/ treatment | ECE2018

Nodule size as predictive factor of efficacy of radiofrequency ablation in treating autonomously functioning thyroid nodules

Palermo Andrea , Naciu Anda Mihaela , Iozzino Mario , Pasqualini Valerio , Simeoni Carla , Manfrini Silvia , Tabacco Gaia , Casini Alessandro , Campagna Giuseppe , Cesareo Roberto

Background: Radiofrequency ablation(RFA) has been advocated as an alternative to radioiodine and/or surgery for the treatment of autonomously functioning benign thyroid nodule (AFTN). However, only a few studies have investigated the efficacy of RFA on AFTN. Furthermore, these studies are characterized by several biases about patient selection, number of RFA treatments, short clinical and radiographic follow-up. A recent prospective 12-month study has demonstrated that one sin...

ea0073aep104 | Calcium and Bone | ECE2021

Evaluation of bone quality by dxa-based bone strain index in primary hyperparathyroidism

Tabacco Gaia , Naciu Anda Mihaela , Messina Carmelo , Rinaudo Luca , Cesareo Roberto , Falcone Stefania , Manfrini Silvia , Napoli Nicola , Bilezikian John , Ulivieri Fabio Massimo , Palermo Andrea

BackgroudPrimary hyperparathyroidism (PHPT) is associated with impaired bone quality and increased fracture risk. Reliable tools for the evaluation of bone quality parameters are not yet clinically available. Bone Strain Index (BSI) is a new metric for bone strength based on Finite Element Analysis from lumbar spine and femoral neck dual X-ray absorptiometry images.AimTo assess the lumbar spine (LS), femoral ...