Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep475 | Diabetes (complications & therapy) | ECE2015

Glycaemic control and weight evolution in type 2 diabetic patients with dapagliflozina in addition to their previous treatment

de Linares Lidia Urbon Lopez , Soto Maria Cristina Crespo , Vina Marta Ventosa , Larumbre Concepcion Terroba , Monclus Claudia Martin , Martin Tomas Martin , Olmedo Luis Cuellar

Introduction: From November 2013 it is available in Spain a new drug to treat type 2 diabetes (DM2): dapagliflozina. The new mechanism of action consists in the inhibition of the sodium–glucose co transporters (SLGT2) inhibiting glucose reabsorption in the proximale tubule and increasing glucose excreted in the urine. Therefore hyperglycaemia decreases and so does weight as a consequence of glycosuria. This is a very convenient side effect since DM2 is highly associated w...

ea0037gp.25.07 | Thyroid – nodule | ECE2015

Malignancy risk stratification of thyroid nodules by TIRADS; correlation with cytological results

Martinez Antonio J , Hernando Virginia , Garcia Clara , Torres Alberto , Martin Tomas

Introduction: Knowing that only in 5–15% of FNABs the pathological analysis shows malignancy, enhance diagnostic accuracy is needed. The use of the TIRADS score and a revised version proposed by the British Thyroid Association (BTA) intend to determine if a FNAB should be performed or not in the evaluation of nodular goitre.Objective: To determine whether an adequate correlation is present between the risk category assigned to the nodules studied un...

ea0016p692 | Thyroid | ECE2008

Rosiglitazone in two patients with thyroglobulin-positive and radioiodine-negative differentiated thyroid cancer

Martin Tomas , Fernandez-Arguelles Amaya , Torres Alberto , Gentil Alfonso , Castro Juan , Cambils Teresa

Thiazolidinediones have demonstrated some efficacy in promoting radioiodine uptake of previously poorly radioiodine-responsive thyroid cancers. We describe the effect of rosiglitazone, in promoting uptake in thyroid metastatic tissue with weak uptake in order to treatment with radioiodine in two patients.Case 1: A 62-year-old woman with thyroid cancer and negative I-131 body scan post therapy (150 mCi) with presence of recurrent disease (PET positive in ...

ea0014p279 | (1) | ECE2007

Family mutation of PRKRA1A associated with Cushing syndrome from pigmented micronodular adrenal dysplasia

Gentil Alfonso , Martin Tomas , Díaz Galvez Milagrosa , Maraver Silvia , Lucas Miguel

Introduction: Pigmented micronodular adrenal dysplasia (PMNAD) is an infrequent cause of Cushing syndrome ACTH-independent, and can form a part of Carney syndrome (CS). In both, regulatory subunit mutations of the protein kinase A (PRKAR1A) have been demonstrated, but without apparent genotype-phenotype correlation.Objective: To demonstrate the mutation of PRKAR1A and its functional and clinical expression in a family affected with PMNAD.<p class="ab...

ea0014p334 | (1) | ECE2007

Hashimoto’s encephalitis: role of diagnostic SPECT

Martin Tomas , Gentil Alfonso , Torres Alberto , Maraver Silvia , Diaz-Galvez Milagrosa

In autoimmune thyroid disease some diverse neurological alterations like dementia, psychosis or peripheral neuropathy, are described. Hashimoto’s encephalopathy (EH) is a serious form of these neurological alterations. We describe three cases with different presentation and morphologic normal tests where cerebral SPECT was diagnostic.Case n°1. A 32-year-old male diagnosed of autoimmune hypothyroidism which presents paresthetics and muscular sti...

ea0032p319 | Clinical case reports - Thyroid / Others | ECE2013

Everolimus. a new therapeutic target in the metastatic neuroendocrine carcinoma

Rodriguez Jose Perez , Hernandez Tomas Martin , Hernandez Cristina , Baz David Vicente , Manzano Virginia Martin , Baldrich Alfonso Gentil , Perez Angel Sendon

Introduction: Everolimus is a drug selective inhibitor of mTOR and approved by the FDA in 2011 for treatment of neuroendocrine tumors of pancreatic origin unresectable. Our objective was to evaluate the efficacy and safety of everolimus in a patient with malignant pancreatic head insulinoma.Case: This is a 31 year old man who complains of epigastric pain, dizziness, sweating and syncope related to exercise. During admission is objectively severe hypoglyc...

ea0032p1112 | Thyroid cancer | ECE2013

Ultrasound guided enolization as a therapeutic alternative in local recurrences of papillary thyroid carcinoma

Hernandez Tomas Martin , Rodriguez Jose Perez , Rivera Natividad Gonzalez , Cuadro Alberto Torres , Garcia Clara Garcia , Manzano Virginia Martin

Introduction and objectives: Multiple surgeries are associated with many complications in the local recurrence of papillary thyroid carcinoma. Our objective is to evaluate the efficiency of the enolization in the recurrent metastatic cervical lymph nodes in patients with limited nodal disease.Material and methods: We studied 13 patients (six males and seven females) with a mean age of 43±14.4 years with papillary thyroid carcinoma intervened (total ...

ea0041ep550 | Diabetes therapy | ECE2016

Effects in weight loss and HbA1c after one year of use of dapaglifozina

de Linares Lidia Urbon Lopez , Soto Maria Cristina Crespo , Terroba Concepcion , Ventosa Marta , Martin Tomas , Calleja Maria del Mar , Cuellar Luis Angel

Changes in HbA1c and weight after 1 year on dapaglifozina added to the previous treatment.SGLT2 inhibitors are becoming a common and useful drug to treat type 2 diabetes.The inhibition of the sodium-glucose co transporters (SLGT2) inhibits also the glucose reabsorption in the proximale tubule and increases the glucose excreted in the urine.Therefore hyperglycemia decreases and so does weight as happens with t...

ea0037gp.23.04 | Thyroid – diagnosis | ECE2015

Impact of antithrombotic and/or anticoagulant treatment in cytological results of thyroid fine-needle biopsy

Molina Carlos Arana , Cuadro Alberto Torres , Rivera Natividad Gonzalez , Garcia Clara Garcia , Jimenez Virginia Hernando , Ojeda Luna Florencio , Hernandez Tomas Martin

Introduction: Fine-needle aspiration biopsy (FNAB) of the thyroid gland is an accurate diagnostic test used routinely in the initial evaluation of nodular thyroid disease. A sizeable subset of patients are found to be taking antithrombotic and/or anticoagulant (AT/AC) medications. This creates a dilemma for the endocrinologist, who must weigh the risk of withholding these medications (and the associated potential benefit of diagnosis) against the perceived increased risk of ia...

ea0037ep870 | Thyroid cancer | ECE2015

Chemotherapy effectiveness in the treatment of non-medullary well-differentiated thyroid cancer: a systematic and case review

Albero Ana , Martin Esther , Torres Alberto , Garcia Teresa , Gonzalez Natividad , de Carmen del Alamo Maria , de la Cruz Luis , Martin Tomas

Introduction: Nowadays, use of chemotherapy in well-differentiated non medullary thyroid cancer, locally advanced stage and/or with radioiodine-refractory metastases is considered of scanty value. However, in the last 40 years was not published any phase III study nor a systematic review of its use in clinical setting.Methods: A systematic literature search was performed in databases such as Medline and Embase, among others. Two independent reviewers ana...