Endocrine Abstracts

Introduction: From November 2013 it is available in Spain a new drug to treat type 2 diabetes (DM2): dapagliflozina. The new mechanism of action consists in the inhibition of the sodium–glucose co transporters (SLGT2) inhibiting glucose reabsorption in the proximale tubule and increasing glucose excreted in the urine. Therefore hyperglycaemia decreases and so does weight as a consequence of glycosuria. This is a very convenient side effect since DM2 is highly associated w...

Introduction: Knowing that only in 5–15% of FNABs the pathological analysis shows malignancy, enhance diagnostic accuracy is needed. The use of the TIRADS score and a revised version proposed by the British Thyroid Association (BTA) intend to determine if a FNAB should be performed or not in the evaluation of nodular goitre.Objective: To determine whether an adequate correlation is present between the risk category assigned to the nodules studied un...

Thiazolidinediones have demonstrated some efficacy in promoting radioiodine uptake of previously poorly radioiodine-responsive thyroid cancers. We describe the effect of rosiglitazone, in promoting uptake in thyroid metastatic tissue with weak uptake in order to treatment with radioiodine in two patients.Case 1: A 62-year-old woman with thyroid cancer and negative I-131 body scan post therapy (150 mCi) with presence of recurrent disease (PET positive in ...

Introduction: Pigmented micronodular adrenal dysplasia (PMNAD) is an infrequent cause of Cushing syndrome ACTH-independent, and can form a part of Carney syndrome (CS). In both, regulatory subunit mutations of the protein kinase A (PRKAR1A) have been demonstrated, but without apparent genotype-phenotype correlation.Objective: To demonstrate the mutation of PRKAR1A and its functional and clinical expression in a family affected with PMNAD.<p class="ab...

In autoimmune thyroid disease some diverse neurological alterations like dementia, psychosis or peripheral neuropathy, are described. Hashimoto’s encephalopathy (EH) is a serious form of these neurological alterations. We describe three cases with different presentation and morphologic normal tests where cerebral SPECT was diagnostic.Case n°1. A 32-year-old male diagnosed of autoimmune hypothyroidism which presents paresthetics and muscular sti...

Introduction: Everolimus is a drug selective inhibitor of mTOR and approved by the FDA in 2011 for treatment of neuroendocrine tumors of pancreatic origin unresectable. Our objective was to evaluate the efficacy and safety of everolimus in a patient with malignant pancreatic head insulinoma.Case: This is a 31 year old man who complains of epigastric pain, dizziness, sweating and syncope related to exercise. During admission is objectively severe hypoglyc...

Introduction and objectives: Multiple surgeries are associated with many complications in the local recurrence of papillary thyroid carcinoma. Our objective is to evaluate the efficiency of the enolization in the recurrent metastatic cervical lymph nodes in patients with limited nodal disease.Material and methods: We studied 13 patients (six males and seven females) with a mean age of 43±14.4 years with papillary thyroid carcinoma intervened (total ...

Introduction: Parathyroid carcinoma (PC) is a very rare neoplasm, which has histopathological features different from those of atypical parathyroid adenomas (APA). However, the clinical course of both tumour types is similar, with the exception of the unusual metastases of the carcinoma. With this study we aim to identify those clinical-analytical and anatomopathological variables that allow us to differentiate PCs from APAs.Material and Methods: Retrosp...

Changes in HbA1c and weight after 1 year on dapaglifozina added to the previous treatment.SGLT2 inhibitors are becoming a common and useful drug to treat type 2 diabetes.The inhibition of the sodium-glucose co transporters (SLGT2) inhibits also the glucose reabsorption in the proximale tubule and increases the glucose excreted in the urine.Therefore hyperglycemia decreases and so does weight as happens with t...

Introduction: Fine-needle aspiration biopsy (FNAB) of the thyroid gland is an accurate diagnostic test used routinely in the initial evaluation of nodular thyroid disease. A sizeable subset of patients are found to be taking antithrombotic and/or anticoagulant (AT/AC) medications. This creates a dilemma for the endocrinologist, who must weigh the risk of withholding these medications (and the associated potential benefit of diagnosis) against the perceived increased risk of ia...