Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep654 | Obesity | ECE2017

Growth hormone signaling and action in obese versus lean human subjects: evidence of increased hepatic GH sensitivity in obesity

Pedersen Morten Hogild , Bak Ann Mosegaard , Pedersen Steen Bonlokke , Jessen Niels , Moller Niels , Jorgensen Jens O.L.

Context: Obesity is accompanied by blunted GH secretion but relatively normal serum IGF-I levels, which suggests increased GH sensitivity. This, however, remains to be tested at the level of GH signaling in human subjects.Objective: To compare the effects of an acute intravenous GH bolus in obese vs normal weight subjects on GH signaling pathways in adipose and muscle tissue, substrate metabolism and insulin sensitivity.Subjects an...

ea0063oc3.4 | Cushing's and acromegaly | ECE2019

Restoration of basal glucose turnover after disease control in acromegaly depends on treatment modality: a prospective, investigator-initiated trial

Arlien-Soborg Mai C , Dal Jakob , Madsen Michael , Hogild Morten , Hjelholt Astrid , Jessen Niels , Moller Niels , Otto Lunde Jorgensen Jens

Background: Growth Hormone (GH) reversibly suppresses insulin-stimulated glucose uptake in skeletal muscle, but less is known about GH effects on glucose metabolism in the basal state. Somatostatin suppresses GH as well as insulin, and may also exert direct effects in skeletal muscle. This may have therapeutic implications in the treatment of acromegalic patients with a somatostatin analogue (SA).Aim: To study basal and insulin-stimulated glucose metabol...

ea0063p209 | Diabetes, Obesity and Metabolism 1 | ECE2019

Insulin sensitivity and counter regulatory responses following hypoglycemia in healthy and type 1 diabetes patients

Bengtsen Mads Bisgaard , Stoy Julie , Rittig Nikolaj Fibiger , Voss Thomas Schmidt , Svart Mads Vandsted , Jessen Niels , Moller Niels

Background and aim: Insulin resistance is associated with type 2 diabetes and obesity but recent studies suggest that it may also be associated with type 1 diabetes (T1D), which may affect glycemic control. Hypoglycemia is a dreaded condition among patients with T1D and may also limit optimal glycemic management. We aimed to investigate insulin sensitivity and metabolic adaptions in healthy control subjects and T1D subjects.Material and methods: <!--SUB:...

ea0056s24.3 | Ups and downs of hypothalamo-pituitary hormones | ECE2018

The role of pituitary hormones (among others) in the generation of metabolic stress responses

Moller Niels

Throughout evolution survival of humanity has relied on the ability to cope with stress, such as fasting, exercise, injury and inflammation. In general these conditions generate a metabolic stress response with release of stress hormones (adrenaline, glucagon, cortisol and growth hormone(GH)) and mobilisation of all major fuel sources - lipids, protein and carbohydrate. In addition bacterial ingredients (eg endotoxin/lipopolysaccharide (LPS)) and cytokines (TNF-alfa, interleuk...

ea0022p324 | Diabetes | ECE2010

Dose--response characteristics for effects of insulin in patients with type 2 diabetes and severe insulin resistance: evidence for the utility of high doses of insulin

Kampmann Ulla , Hoyem Pernille , Mengel Anette , Orskov Lotte , Moller Niels

Background: To avoid the serious complications of diabetes glucose control must be tackled aggressively in type 2 diabetes. However some patients with type 2 diabetes are severely insulin resistant and although they are treated with large doses of insulin their blood glucose is still not optimally controlled.Aim: This project aims to determine the doseĀ–response to insulin in patients with type 2 diabetes and severe insulin resistance.<p class="a...

ea0022p508 | Growth factors | ECE2010

Insulin resistance induced by GH is transient and reversible: glucose clamp studies during different ambient GH levels in GH-deficient adults

Krusenstjerna-Hafstrom Thomas , Moller Niels , Christiansen Jens Sandahl , Jessen Niels , Jorgensen Jens Otto Lunde

Background: The impact of GH on insulin sensitivity is ambiguous since both long standing GH-deficiency as well as acute GH exposure and prolonged GH-excess are associated with insulin resistance.Aim: To test the hypotheses that the insulin antagonistic effect of GH i) is dynamic and depend on ambient GH levels and ii) subsides gradually with time after GH exposure.Methods: Eight GHDA participated in a randomised crossover study. E...

ea0020p462 | Obesity and Metabolism | ECE2009

Impact of growth hormone receptor blockade on substrate metabolism during short-term fasting in healthy subjects

Moller Louise , Norrelund Helene , Frystyk Jan , Moller Niels , Jorgensen Jens OL

Context and objective: During fasting growth hormone (GH) promotes lipolysis, attenuates glucose oxidation and preserves protein. Previous studies have primarily been conducted in GH deficient patients or during somatostatin-suppression of GH secretion. We aimed to study the impact of the fasting associated increase in GH without concomitant changes in other hormones, by the means of GH receptor (GHR) blockade.Design: Ten healthy young men participated i...

ea0016p740 | Thyroid | ECE2008

Serum ghrelin levels are increased in hypothyroid patient and become normalized after L-thyroxin treatment

Gjedde Signe , Vestergaard Esben Thyssen , Gormsen Lars Christian , Riis Anne Lene , Rungby Jorgen , Moller Niels , Weeke Jorgen , Jorgensen Jens Otto

Context: An interaction between gut-derived ghrelin, which is implicated in the regulation of short- and long-term energy balance, and thyroid function has previously been reported in patients with hyperthyroidism, in whom ghrelin levels are reversibly suppressed. In the present study, we measured total serum ghrelin levels and pertinent metabolic indices in hypothyroid patients before end after L-thyroxin replacement.Patients and methods:...

ea0041oc13.2 | Pituitary Clinical | ECE2016

Growth hormone and insulin signalling after acute GH exposure in patients with controlled acromegaly: impact of surgery versus somatostatin analog treatment

Dal Jakob , Lundby Hoyer Katrine , Pedersen Steen B , Magnusson Nils , Bjerrring Peter , Frystyk Jan , Moller Niels , Jessen Niels , Jorgensen Jens Otto L

Background: Somatostatin analogue treatment (SA) is used in acromegaly to suppress GH secretion and tumour growth. In addition, SA also suppresses insulin secretion and may impact on GH signalling in peripheral tissues.Objective: To compare GH and insulin signalling in skeletal muscle and adipose tissue in vivo before and after a single exogenous GH bolus in patients with acromegaly controlled by either surgery alone or by ongoing treatment with a slow-r...

ea0014p67 | (1) | ECE2007

Intravenous constant ghrelin infusion in healthy young men: sustained cardiovascular effects of supraphysiological ghrelin levels

Vestergaard Esben Thyssen , Andersen Niels Holmark , Hansen Troels Krarup , Rasmussen Lars Melholt , Moller Niels , Sorensen Keld , Sloth Erik , Christiansen Jens Sandahl , Jorgensen Jens Otto Lunde

Objective: The short-term cardiovascular effects of continuous ghrelin infusion in healthy humans remain to be studied.Methods: Fifteen healthy, young and normal-weight men volunteered to participate in a randomized double-blind, placebo-controlled cross-over study. The local ethics committee approved the study. We used a constant infusion of human ghrelin at a rate of 5 pmol/kg body weight per minute for 180 minutes and measured peak left ventricular my...