Searchable abstracts of presentations at key conferences in endocrinology

ea0081p284 | Adrenal and Cardiovascular Endocrinology | ECE2022

Ang-Tie pathway in adrenocortical tumors angiogenesis

Oliveira Sofia , Pereira Sofia , Costa Madalena M. , Monteiro Mariana P , Pignatelli Duarte

The majority of adrenocortical tumors (ACT) are benign and hormonally non-functioning, in contrast to adrenocortical carcinomas (ACC), which are rare and usually very aggressive tumors. The differential diagnosis between these two entities is mainly based on unspecific and subjective criteria, contributing to the inaccuracy of diagnosis. Due to ACC molecular and biological heterogeneity, prognostic factors have a limited capacity to predict ACC clinical outcomes, leading to an...

ea0081p587 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

GLP-1 and glucagon depict complementary actions on visceral adipose tissue that could mediate metabolic shifts towards catabolism

Morais Tiago , Seabra Alexandre , Patricio Barbara , Guimaraes Marta , Nora Mario , Oliveira Pedro , Alves Marco , Monteiro Mariana

Visceral adipose tissue (VAT) metabolic fingerprints differ according to the individual’s BMI and glycemic status. GLP-1 and Glucagon are two hormones that participate in energy homeostasis and glycemic control. Dual GLP-1/Glucagon agonists are a drug class under development for obesity and diabetes treatment. Although the pancreas and the liver are considered major GLP-1 and glucagon targets, these hormones act in other tissues, which could contribute for its effects on ...

ea0090p470 | Reproductive and Developmental Endocrinology | ECE2023

Unveiling follicular fluid oxidative stress biomarkers at polycystic ovary syndrome

Moreira Mafalda V. , Vale Fernandes Emidio , Bernardino Raquel , Alves Marco , P Monteiro Mariana

Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine disorder of women at reproductive-age and accounts for 80% of the causes of anovulatory infertility. Despite the widely characterized reproductive, endocrine, and metabolic abnormalities, the mechanisms underlying PCOS remain unclear. Thus, it is essential to identify novel biomarkers that will allow to disclosure novel pathways involved PCOS pathophysiology, which could then be used to improve PCOS manage...

ea0049gp18 | Adrenal 2 | ECE2017

Effects of two mineralocorticoid receptor antagonists on the morphology of the adrenal cortex

Pereira Sofia S , Costa Madalena M , Moreira Angela , Carvalho Liliana , Monteiro Mariana , Vinson Gavin , Pignatelli Duarte

Arterial hypertension usually results from the deregulation and hyperactivity of the renin angiotensin-aldosterone system. One of the available therapeutic approaches for its treatment is the use of mineralocorticoid receptor (MR) antagonists, thus blocking aldosterone action.The aim of this study was to characterize the effects of spironolactone and eplerenone, on the morphology of the adrenal gland of spontaneously hypertensive (SHR) and normotensive (...

ea0070aep55 | Adrenal and Cardiovascular Endocrinology | ECE2020

Steroidogenic proteins expression pattern in adrenocortical carcinomas

Pereira Sofia S , Costa Madalena M , Gomez-Sanchez Celso E , Monteiro Mariana P , Pignatelli Duarte

Introduction: The majority of adrenocortical carcinomas (ACC) autonomously produce steroids. However, urinary steroid profile of patients with ACC revealed that these tumors secrete and release predominantly intermediate metabolites. This steroid secretion pattern could be attributed to the undifferentiated status of the tumor cells expressing an incomplete pattern of enzymes involved in the steroidogenic cascade.Aims: Our study aim was to analyze the ex...

ea0073pep4.4 | Presented ePosters 4: Reproductive and Developmental Endocrinology | ECE2021

Insulin production by human spermatozoa in response to glucose stimuli

Carrageta David F. , Oliveira Pedro F. , Barros Alberto , Monteiro Mariana P. , Alves Marco G.

IntroductionMetabolic homeostasis in the testis is essential for a healthy spermatogenesis. Insulin is regarded as one of the most important intervenients in the metabolic regulation of spermatogenesis, where it acts directly on the differentiation of spermatogonia into primary spermatocytes or indirectly through the metabolic modulation of Sertoli cells. Additionally, insulin is hypothesized to play a major role on human spermatozoa capacitation, althou...

ea0099p398 | Late-Breaking | ECE2024

GIP receptor is expressed by human cumulus granulosa cells

V. Moreira Mafalda , Pignatelli Duarte , Bernardino Raquel , Vale Fernandes Emidio , P Monteiro Mariana

Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women of reproductive age and, accounts for 80% of the causes of anovulatory infertility. Despite PCOS being often associated with obesity and insulin-resistance, these are not invariably present. As PCOS aetiology and underlying mechanisms remain unclear, clinical management is limited to target symptoms. Recent evidence suggested the potential of GLP-1 receptor agonists therapies in ameliorating P...

ea0049ep146 | Endocrine tumours and neoplasia | ECE2017

Glucose metabolism abnormalities and insulin resistance are frequent in well diferentiated digestive NETs

Santos Ana P , Santos Ana C , Castro Clara , Raposo Luis , Torres Isabel , Henrique Rui , Monteiro Mariana P , Cardoso M Helena

Introduction: Incidence of Digestive NETs (DNETs) has increased in the last 40 years. Visceral obesity, metabolic syndrome (MetS) and insulin resistance (IR) have been associated with several types of cancer.Aim: To evaluate possible associations of obesity, hyperinsulinemia and IR with well-differentiated (WD) DNETs through a case control study.Materials and methods: Ninety-six patients with gastrointestinal (75.0%) and pNET (22.9...

ea0049ep1179 | Male Reproduction | ECE2017

Leptin modulates Sertoli cells mitochondrial function and biogenesis with implications for the nutritional support of spermatogenesis

Moreira Bruno M , D Martins Ana , Monteiro Mariana P , Sousa Mario , Alves Marco G , Oliveira Pedro F

Current lifestyle, characterized by physical inactivity and a poor diet, is heavily linked with an increased incidence of metabolic diseases. One of the most serious silent co-morbidities of those diseases is infertility. The hormonal link between food intake and energy homeostasis is mediated by the leptin ghrelin axis. Compelling evidence suggests that direct leptin’s action regulates cellular glucose homeostasis and mitochondrial biogenesis. We have recently shown that...

ea0081ep893 | Reproductive and Developmental Endocrinology | ECE2022

Mitochondrial uncoupling proteins (UCPs) regulate the mitochondrial activity of human sertoli cells

Carrageta David F. , Freire-Brito Lais , Monteiro Bruno S. , Guerra-Carvalho Barbara , Bernardino Raquel L. , Oliveira Pedro F. , Monteiro Mariana P. , Alves Marco G.

Introduction: Mitochondrial uncoupling proteins (UCPs) are channel proteins present in the mitochondrial inner membrane which are responsible for the transport of protons between the mitochondrial intermembrane space and the matrix. Currently, six UCP homologues had been identified (UCP1-6). UCPs are major regulators of reactive oxygen species (ROS) production, general cellular redox state and metabolism. UCPs also exhibit specific functions, such as UCP1 and thermogenesis or ...