Searchable abstracts of presentations at key conferences in endocrinology

ea0067gp29 | Poster Presentations | EYES2019

Relapsed acromegaly after 3 years of remission following pituitary apoplexy

Dobre Ramona , Niculescu Dan Alexandru , Poiana Catalina

Background: Pituitary apoplexy is a rare clinical syndrome manifested by rapid enlargement of a pituitary mass. When apoplexy occurs in functioning adenomas, it may result in spontaneous remission with or without associated hypopituitarism. Cases of recurrence in such patients are reported in literature.Case description: We present a case of a 44 years old male, overweight and dyslipidemic that presented to our clinic in 2016 and was diagnosed with acrom...

ea0063p480 | Calcium and Bone 2 | ECE2019

Seasonal variation of osteoporotic hip fracture admitted in trauma centers in Bucharest

Dobre Ramona , Niculescu Dan Alexandru , Poiana Catalina

Hip fracture remains the most important clinical manifestation of osteoporosis, with many studies demonstrating a relationship between seasons and the incidence and mortality after hip fracture.Objective: We aimed to identify a seasonal variation (four seasons) in incidence of osteoporotic hip fracture admitted in trauma centers in Bucharest.Materials and methods: We observed the seasonal variation of 1176 patients, mean age 78.19+...

ea0049ep1018 | Pituitary - Clinical | ECE2017

Disposition index in active acromegaly: A pilot study

Niculescu Dan Alexandru , Dusceac Roxana , Caragheorgheopol Andra , Popescu Nicoleta , Poiana Catalina

Background: Active acromegaly is characterized by decreased insulin sensitivity (ISen). However, insulin secretion (ISec) may not increase satisfactorily to compensate for the low ISen.Aim: To assess ISen and ISec and to calculate disposition index (DI) using an intravenous glucose tolerance test (IVGTT) in patients with active acromegaly.Methods: Twelve patients (7 men, 5 women) with active acromegaly and 2 normal subjects (2 men)...

ea0056p181 | Bone ' Osteoporosis | ECE2018

PTH correlates with bone turnover serum markers in patients with end stage renal disease

Dusceac Roxana , Niculescu Dan Alexandru , Dragne Madalina Cristina , Dobre Ramona , David Cristiana , Tacu Cristian , Poiana Catalina

Background: End stage renal disease is usually associated with high serum parathyroid hormone (PTH) and increased bone turnover. The aim of our study was to correlate serum PTH with serum markers of bone turnover in patients with end stage renal disease (ESRD).Methods: We measured serum PTH, osteocalcin, procollagen type 1 n-terminal propeptide (P1NP) and beta-crosslaps in 64 (32 men) consecutive pacients, median (25, 75 percentile) age 61 (49.5, 65.5) y...

ea0081ep675 | Pituitary and Neuroendocrinology | ECE2022

Association between acromegaly and papillary thyroid cancer: A case series

Anne-Marie Stefan Andreea , Ioana Dumitriu Roxana , Iulia-Florentina Burcea , Raluca Trifănescu , Niculescu Dan Alexandru , Poiana Catalina

Background: Acromegaly is a rare disorder caused by hypersecretion of growth-hormone (GH) and insulin-like growth factor (IGF-1), the underlying lesion being most frequently a pituitary adenoma. This disease is associated with a higher risk of malignancy. We describe the clinical and biochemical particularities in a series of patients with acromegaly and papillary thyroid carcinoma (PTC).Case study: Out of 311 acromegalic patients, five cases that associ...

ea0041gp21 | Adrenal (2) | ECE2016

Clinical characteristics and tumour size evolution in patients with bilateral adrenal tumours

Galoiu Simona , Pena Raluca , Trifanescu Raluca , Niculescu Dan Alexandru , Dumitrascu Anda , Caragheorgheopol Andra , Iordachescu Carmen , Poiana Catalina

10% of patients with adrenal tumours have bilateral lesion.Objective: To evaluate clinical, imagistic and hormonal characteristics of bilateral adrenal tumours.Design and mehods: Retrospective series of 150 consecutive patients (104F, 46M) with bilateral adrenal tumours with maximal diameter of at least 1 cm, evaluated from 2001 to 2015 in a tertiary endocrinology clinic with clinical, hormonal and imagistic methods.<p class="a...

ea0081ep637 | General Endocrinology | ECE2022

Vitamin D status in patients with adrenal tumors and previous COVID-19 infection

Alexandra Mohora Maria , Trifanescu Raluca , Toma Iustin- Daniel , Dusceac Roxana , Capatina Cristina , Niculescu Dan Alexandru , Schipor Sorina , Vladoiu Suzana Vilma , Poiana Catalina

Context: The current pandemic showed a great handling of the resources and research in order to find not only a way to cure but also to prevent and improve the course of the Covid-19 infection. Optimal vitamin D (VD) levels and treatment was seen as a potential aid due, in principal, to its immunomodulatory effect. The ACE-2 receptor is the key the virus uses for entering the body, but its location is not restricted to the lungs, itÂ’s also found in the adrenal cortex. At ...

ea0081ep985 | Thyroid | ECE2022

An unusual association between medullary thyroid carcinoma and testicular seminoma: Chemotherapy-induced complications, genetic predisposition or random relationship?

Septar AIlin , Smarandache Romeo , Niculescu Dan Alexandru , Goldstein Andrei , Braha Elena , Muresan Andrei , Caragheorgheopol Andra , Terzea Dana , Constantin Teodor , Buduluca Larisa , Musat Madalina

Medullary thyroid carcinoma (MTC) is a rare malignancy arising from parafollicular C cells of the thyroid gland, sometimes due to germline mutations in the RET protooncogene. Testicular cancer is the most common malignancy in men aged 15 - 40 years with survival rates improved by the introduction of cisplatin therapy in the late 1970s. Nonetheless, platinum-based chemotherapy was shown to increase the risk of a solid second cancer with substantially increased site-specific ris...

ea0090ep795 | Pituitary and Neuroendocrinology | ECE2023

Coexistence of acromegaly and autoimmune disorders: Between hazard and causality – a case series

Iftimie Mădălina Elena , Iulia-Florentina Burcea , Dobre Ramona , Trifanescu Raluca , Niculescu Dan Alexandru , Baciu Ionela , Radian Serban , Capatana Cristina , Poiana Catalina

Introduction: Acromegaly is a rare, chronic endocrinopathy, that results from persistent hypersecretion of growth hormone (GH) and consequently of insulin-like growth factor 1 (IGF1). It is well known that GH excess has multisystemic effects throughout the body, but its interaction with the immune system has only been suggested in the last few decades. This prompted us to explore the frequency of autoimmune disorders in a retrospective acromegaly cohort....

ea0063p1063 | Pituitary and Neuroendocrinology 3 | ECE2019

Cumulative GH exposure as risk factor for mortality and morbidity in patients with acromegaly

Galoiu Simona , Silea Simona , Mailat Monica , Baciu Ionela , Trifanescu Raluca Alexandra , Niculescu Dan Alexandru , Capatina Cristina , Radian Serban , Baculescu Nicoleta , Caragheoorgheopol Andra , Dumitrascu Anda , Poiana Catalina

Background: In patients with acromegaly, mortality depends most on achievement of control of GH/IGF1 levels. However, some of the complications of acromegaly still develop, despite successful control of disease. The aim of the study is to correlate mortality and morbidity with cumulative GH exposure in these patients compared to last GH/IGF1 level.Methods: We studied retrospectively 336 patients with acromegaly consecutively evaluated at least twice duri...