Endocrine Abstracts

Aim: Radioiodine activities for the treatment of Graves’ disease hyperthyroidism are still subject to discussion, as is the use of a fixed approach over a dosimetric one. We aimed to evaluate our success rate using a personalized dosimetric approach: instead of the “(MBq I-131×g gland mass×100)/(percentage uptake at 24 h)” activity calculation, we further adjusted for factors such as gender, age, diagnosis, 2 h and 4 h radioiodine uptake, previous medi...

Cushing’s Syndrome (CS) is an uncommon disease worldwide, being characterized by an increased production of glucocorticoids, and if left untreated can lead to serious consequences and women with CS rarely get pregnant. The aim of our work is to make a systematic review of the cases of pregnancy in patients with previously diagnosed CS, being performed an extensive research of the Medline and Web of Knowledge databases, and add three new cases observed in our institution. ...

Introduction: Primary thyroid lymphoma is rare and accounts for less than 5% of all thyroid malignancies. The risk is almost 60 times higher in those with thyroiditis and is more common in females, with a ratio of 4:1. The most frequent local symptom is a rapidly enlarging thyroid gland along with the resultant obstructive symptoms. Fine needle aspiration is the initial diagnostic procedure for thyroid tissue sampling. The main differential diagnosis is anaplastic thyroid carc...

Introduction: Prolactinomas are mostly benign tumours usually managed with pharmacological treatment. Some, however, seem to be resistant to dopamine agonists (DA) for unclear reasons. The relationship between T2W signal intensity (T2WSI) and response to treatment with somatostatin analogs is well described in acromegaly patients. Some evidence suggests that prolactinoma’s T2W hypointensity might be related to higher baseline prolactin levels and more resistance to DA.</p...

Background and Aim: Unacylated ghrelin (UAG) is the major form of circulating ghrelin. Initially considered as a non-functional peptide, soon after UAG has been associated to a negative action on energy balance, suppression of hepatic glucose production and decrease in circulating levels of insulin. The aim of this study was to analyze the association between the serum levels of UAG and glucose metabolism parameters in obese women, independently from the eventual interference ...

Introduction: The incidence of glucose metabolism alterations during the follow-up of surgically treated insulinomas is largely unknown. Our aim was to evaluate the incidence, and the clinical characteristics, of diabetes and prediabetes in this population.Methods: We retrospectively analyzed the cases diagnosed as insulinomas in a Central Hospital in Portugal in the period between January 1980 and December 2015.Results: We identif...

Introduction: Insulinomas are pancreatic endocrine tumors originating in the beta cells, characterized by hypoglycemia resulting from insulin hypersecretion.Objectives: To characterize the demography, the clinical features, imagiological findings and pathological evaluation of the cases of insulinomas identified in the previous 35 years at São João Hospital.Methods: We retrospectively analyzed the cases diagnosed as insul...

Background: Obesity represents a cardiovascular risk factor. Monocyte chemoattractant protein-1 (MCP-1) is a known regulator of monocyte recruitment to sites of inflammation, and participates at the early phases of atherogenesis. Apolipoproteins, as part of the lipoprotein particles, are classically coupled with cardiovascular risk distinction.Aims: To assess the association of anthropometric parameters, insulin resistance and MCP-1 levels with classic l...

Introduction: Madelung’s disease is a rare disorder characterized by a disturbance in the adipocyte metabolism. Mainly occurs in alcoholic Mediterranean male, presenting multiple, symmetrical lipomas.Case report: A 49-year-old obese man with a history of alcoholism, complaint of weight gain, soft and slow-growing swelling of the neck, and shoulders. His past history: epilepsy, alcoholic CHD, hypothyroidism, severe sleep apnea, vitiligo and HTA. His ...

Background: Although acyl–ghrelin has been considered essential for ghrelin’s GH-releasing activity, several recent in vitro studies have shown that desacyl–ghrelin exhibits biological activities on metabolism and proliferation of adipocytes, myocytes, cardiomyocytes, and myelocytes. The full desacyl–ghrelin biological activity still remains a matter of debate.Aims: To assess desacyl–ghrelin circulating levels and its R51Q...