Searchable abstracts of presentations at key conferences in endocrinology

ea0090ep183 | Calcium and Bone | ECE2023

Severe hypocalcemia during respiratory alkalosis reveals a case of Pseudohipoparathyroidism type 1B

Roque Catarina , Fonseca Ricardo , Osorio Ana Sofia , Oliveira Sofia , Machado Catarina

We present a case of Inactivating PTH/PTHrP signalling disorder (IPPSD) revealed in aduthood in the context of respiratory alkalosis caused by covid-19 infection that led to worsening of the preexisting hypocalcemia and intensification of the usual hypocalcemic symptoms. A 39 year old female with history of subclinical hypothyroidism and bilateral cataracts was admited due to hypoxemia in the context of severe covid-19 infection with bilateral pulmonary infiltrates. She was vi...

ea0090p527 | Thyroid | ECE2023

Preoperative thyroid tumor markers significance - two case reports of misleading values

Fonseca Ricardo , Roque Catarina , Sofia Osorio Ana , Castro Oliveira Sofia

Background: Basal tumor markers are valuable in preoperative evaluation of medullary thyroid carcinoma (Calcitonin and CEA), but are insensitive and nonspecific for papilary thyroid cancer (thyroglobulin). Even if their utility is questionable or not recomended in the evaluation of thyroid nodules, in some cases refered to endocrinology department they are available and can be misleading. We present two cases of thyroid nodules with very high preoperative tumor markers.<p ...

ea0041ep426 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Diagnostic and therapeutic stratagies in maturity onset diabetes of the young

Oliveira Sofia , Neves Celestino , Esteves Cesar , Pignatelli Duarte , Carvalho Davide

Background: Maturity onset diabetes of the young (MODY) has an estimated prevalence of 1–5% in the diabetic population, but misdiagnosis as type 1 or type 2 diabetes is common. It comprises a heterogeneous group of monogenic diseases characterized by primary dysfunction of β cell, young onset, autosomal dominant inheritance, without autoimmunity and without ketosis. Early diagnosis remains a challenge with important future implications, since it allows treatment opti...

ea0081p284 | Adrenal and Cardiovascular Endocrinology | ECE2022

Ang-Tie pathway in adrenocortical tumors angiogenesis

Oliveira Sofia , Pereira Sofia , Costa Madalena M. , Monteiro Mariana P , Pignatelli Duarte

The majority of adrenocortical tumors (ACT) are benign and hormonally non-functioning, in contrast to adrenocortical carcinomas (ACC), which are rare and usually very aggressive tumors. The differential diagnosis between these two entities is mainly based on unspecific and subjective criteria, contributing to the inaccuracy of diagnosis. Due to ACC molecular and biological heterogeneity, prognostic factors have a limited capacity to predict ACC clinical outcomes, leading to an...

ea0049ep169 | Endocrine tumours and neoplasia | ECE2017

Respiratory symtoms lead to a diagnosis of pheochromocytoma: An unusual presentation

Teles Luis , Neves Joao Sergio , Souteiro Pedro , Oliveira Sofia Castro , Neves Celestino , Freitas Paula , Carvalho Davide

Introduction: Pheochromocytoma is one of the major secondary causes of hypertension. The classic triad of pheochromocytoma symptoms of headache, sweating and tachycardia is not present in a high percentage of patients and is sometimes diagnosed as incidentaloma or atypical presentations.Case report: The authors present a 56-year-old man, with no known diseases, referred to Endocrinology evaluation by incidentaloma of the right adrenal gland, from the Pne...

ea0049ep493 | Diabetes (to include epidemiology, pathophysiology) | ECE2017

Bronze diabetes – a rare secondary cause of diabetes

Souteiro Pedro , Neves Joao Sergio , Oliveira Sofia Castro , Belo Sandra , Neves Celestino , Freitas Paula , Carvalho Davide

Introduction: Secondary causes of diabetes refer to a category in which diabetes is associated with other diseases. They are thought to constitute less than 2% of the total cases of diabetes.Case report: A 56 year-old caucasian man, with no relevant medical history, presented to the Emergency Department with fatigue, polyuria, polydipsia, polyphagia and involuntary weight loss (6 kg in two weeks). He was hemodynamically stable and exhibited a glycaemia o...

ea0049ep613 | Diabetes therapy | ECE2017

The insulin delivery system and its impact on quality of life and on psychopathological symptomatology

Pereira Miguel , Neves Celestino , Esteves Cesar , Oliveira Sofia , Arteiro Cristina , Coelho Rui , Carvalho Davide

Introduction: In chronic diseases a good psychological and behavioral adaptation is essential. Concerning diabetes the Insulin Delivery System (IDS) adopted tend to be an important factor of adaptation, global satisfaction and, above all, quality of life (QoL).Objectives: To analyze the QoL and IDS satisfaction and its relationship with psychopathological symptomatology in patients on continuous subcutaneous insulin infusion (CSII) therapy.<p class="...

ea0049ep1081 | Pituitary - Clinical | ECE2017

Hypopituitarism and central diabetes insipidus in an HIV patient – a late complication of cerebral toxoplasmosis and/or antiretrovirals?

Oliveira Sofia Castro , Souteiro Pedro , Neves Joao Sergio , Nogueira Claudia , Neves Celestino , Freitas Paula , Carvalho Davide

Introduction: The endocrine system is often affected in the course of HIV infection. However, hypopituitarism and diabetes insipidus are uncommon disorders in these patients and have been related to drugs, infections of the central nervous system and neoplastic infiltration, in extremely rare cases.Case report: We present a case of a 42-year-old man with HIV infection known since 2005, but undergoing antiretroviral therapy only since 2010 (emtricitabine/...

ea0041ep548 | Diabetes therapy | ECE2016

Intensive therapy with insulin pump in type 1 diabetes mellitus

Gouveia Ines , Neves Celestino , Oliveira Sofia , Neves Joao Sergio , Dias Claudia , Carvalho Davide

Background: Continuous subcutaneous insulin infusion (CSII), alongside multiple daily injections (MDI) are the most frequent therapeutic of type 1 Diabetes Mellitus (DM). We aimed to evaluate the effects of the transition from MDI to CSII in the treatment of type 1 DM.Patients and methods: This retrospective longitudinal study analysed patients that received treatment with CSII from 2006 to 2014. Our sample had 85 patients, 35 male (41.2%) and 50 female ...

ea0032p1030 | Thyroid (non-cancer) | ECE2013

Radioiodine treatment of hyperthyroidism in the elderly

Azevedo Teresa , Martins Teresa , Neto Joao , Oliveira Sofia , Rovira Eugenia , Rodrigues Fernando

Introduction: Treatment of hyperthyroidism in older adults is crucial to reduce its morbidity and mortality. Radioactive iodine has been widely used in this age group due to its efficacy, safety and cost-effectiveness.Aim: To determine the efficacy of 131I for treatment of hyperthyroidism in the elderly.Methods: Retrospective study of 86 hyperthyroid patients aged ≥65 years who performed radioiodine therapy. We eva...