Endocrine Abstracts

Osteoporosis affects more than 75 million people in Europe, United States and Japan, and more than 4.5 million osteoporotic fractures occur in Europe and United States. The aim of treating osteoporosis is to reduce risk of fractures and to improve quality of life of patients with preexisting fractures. Several interventions to prevent and reduce fracture risk are being recommended. These include adequate intake of calcium (at least 1000 mg per day), vitamin D (at least 800 mg ...

Introduction: Primary hyperparathyroidism (pHPT) is the unregulated overproduction of parathyroid hormone resulting in abnormal calcium homeostasis. The prevalence has been reported to be ~21 cases/100 000 person-years. The mean age at diagnosis has remained between 52 and 56 years with female-to-male ratio 3:1. In ~85% of cases, pHPT is caused by a single adenoma, in 14% of hyperplasia and 1% is caused by malignant diseases. Association between pHPT and cardiovascular manifes...

Objective: Several studies report the association of low testosterone with ischaemic heart disease although the results are inconsistent. In our study we tried to evaluate the relationship between sex hormones and incidence of acute coronary syndrome (ACS).Methods: This was a cross-sectional study. In 111 subjects (69 patients with ACS and 42 age-matched controls) we measured total testosterone, estradiol, SHBG, FSH, and LH by electrochemiluminiscence an...

Introduction: Hyperthyroidism is a common endocrine disorder that is associated with prominent cardiovascular manifestations. Recent studies also suggest a potential link between hyperthyroidism and pulmonary hypertension (PH). Right-sided heart failure with clinical manifestation is only occasionally seen in patients with Graves’ disease. The prevalence and pathogenic mechanisms of hyperthyroidism-related PHT remain unclear but based on literary data an autoimmune mechan...

Objective: 25-OH vitamin D3 (D3) possibly affects testosterone production. In some cross sectional studies the level of D3 correlates positively with total testosterone (TT) and free androgen index (FAI). In the European Male Ageing Study positive association of D3 with secondary and compensated hypogonadism was confirmed.Aim: The aim of the study was to determine the relationship between D3 levels and levels of TT, LH, FSH and FAI in men. Secondary aim ...

Introduction: Hyponatremia is the most common disorder of electrolytes encountered in clinical practice, occurring in up to 15–30% of both acutely and chronically hospitalized patients. Although most cases are mild and relatively asymptomatic, it is important clinically because: i) acute severe hyponatremia can cause substantial morbidity and mortality, ii) mortality is higher in patients with hyponatremia who have a wide range of underlying diseases and iii) overly rapid...

Introduction: The adverse impact of overt hypothyroidism that complicates pregnancy outcomes is well-established. In order to eliminate these complications has long been discussion about the need for early detection of the disease of the thyroid gland in the population of women planning pregnancy, respectively in early pregnancy. In Slovakia, this effort resulted in the approval of screening for thyroid diseases in pregnancy and has been enshrined in a legislative in 2009. Obl...

Introduction: More than half of osteopenic patients suffer from fracture (Fx), but BMD osteopenia is usually not considered for treatment initiation. FRAX, tool that can identify patients with high Fx risk based on major risk factors, can be used as an interventional threshold. Past few years, trabecular bone score (TBS), the bone quality determinant, is a promising method identifying the high-risk patients according to degradation of trabecular bone.Obj...

Introduction: GH deficiency (GHD) is associated with reduced bone mineral density (BMD) and treatment leads to its increase. BMD, a quantitative bone parameter, doesn’t bring whole information about bone status. Nowadays, bone quality shows as main determinant of bone strength, fracture prediction and treatment effect monitoring. A method to assess bone quality through the grey-level texture analysis from lumbar spine DXA scan is trabecular bone score (TBS).<p class="...

The presence of pheochromocytoma/paraganglioma can be characterized by typical clinical signs, due to hemodynamic and metabolic activity of circulating catecholamines or less a consequence of other amines or neuropeptides produced simultaneously. But the clinical picture can be also very different and can play a clinical picture of other diseases.The authors present a case report from a patient with retroperitoneal paraganglioma. The patient was admitted...