Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep164 | Calcium and Bone | ECE2022

The clinical presentation of primary hyperparathyroidism during the Covid-19 pandemic

Castellano Elena , Borretta Giorgio , Pellegrino Micaela , Tassone Francesco , Craparo Andrea , Baffoni Claudia , Gianotti Laura

Background: In the last decades, the clinical profile of PHPT in Western Countries has changed from a highly symptomatic to a largely asymptomatic disease. However, a substantial stability in its clinical features has been reported in the last two decades. The usual management, including time to diagnosis and treatment, of PHPT during the Covid-19 pandemic has been changed and likely slowed down. Whether further changes in the clinical presentation of PHPT have occurred during...

ea0049ep268 | Calcium & Vitamin D metabolism | ECE2017

Gender difference in clinical presentation of primary hyperparathyroidism

Gianotti Laura , Castellano Elena , Tassone Francesco , Baffoni Claudia , Cesario Flora , Magro Gianpaolo , Pellegrino Micaela , Borretta Giorgio

Objective: Primary hyperparathyroidism (PHPT) is one of the most common endocrine disorders, with a female to male ratio of 3:1. Currently most patients with PHPT are asymptomatic. However, data about the gender impact on the clinical presentation of PHPT are lacking.Methods: We evaluated the difference in symptoms and biochemical parameters between men and women with PHPT in a single center series of 417 patients.Results: Male PHP...

ea0041oc7.4 | Cardiovascular endocrinology | ECE2016

Cortisol autonomy is associated with increased risk of cardiovascular events and mortality in patients with adrenal incidentalomas: beneficial effects of a selective use of adrenalectomy

Reimondo Giuseppe , Mbachu Elena , Pellegrino Micaela , Pia Anna , Pepe Emanuele , Borretta Giorgio , Terzolo Massimo

Introduction: Cortisol autonomy may be frequently demonstrated in patients with adrenal incidentaloma and this has been associated to increased cardiovascular (CV) risk. However, only few data are available on CV events and related mortality in such patients. Aims of the study were: 1) to stratify CV events and mortality by the degree of cortisol secretion; 2) to evaluate the effect of adrenalectomy on CV events and mortality.Methods and Design: Data of ...

ea0037ep264 | Calcium and Vitamin D metabolism | ECE2015

Measuring BMD at forearm aids in diagnosing osteoporosis and identifies more patients for surgery in asymptomatic primary hyperparathyroidism

Gianotti Laura , Castellano Elena , Tassone Francesco , Pellegrino Micaela , Ghio Michela , Racca Anna , Borretta Giorgio

Introduction: Reduction in bone mineral density (BMD) is a common feature in primary hyperparathyroidism (PHPT), involving mostly cortical site. In the management of asymptomatic PHPT (aPHPT), guidelines indicate measuring BMD at lumbar spine, hip and forearm and surgery is recommended for patients with a T-score of −2.5 or less at one of these sites. However, BMD at forearm is not always performed.Aim: Our aim was to evaluate the impact o...

ea0032p129 | Calcium and Vitamin D metabolism | ECE2013

Does recognition of vitamin D deficiency affect the indication for surgical treatment in asymptomatic primary hyperparathyroidism?

Gianotti Laura , Tassone Francesco , Pellegrino Micaela , Baffoni Claudia , Cassibba Sara , Magro Gianpaolo , Cesario Flora , Borretta Giorgio

Introduction: Current guidelines for the management of asymptomatic primary hyperparathyroidism (A-pHPT) recommend that 25-hydroxyvitamin D levels should be assessed in all patients and vitamin D deficiency (VDD) should be cautiously corrected. It is unknown whether VDD affects the probability to meet surgical criteria currently proposed for A-pHPT. Aim of study was to evaluate whether VDD recognition affects the probability to meet surgical criteria in A-pHPT patients.<p ...

ea0022oc6.2 | Bone | ECE2010

Association between serum osteocalcin and insulin sensitivity in primary hyperparathyroidism

Gianotti Laura , Tassone Francesco , Pellegrino Micaela , Baffoni Claudia , Croce Chiara Giulia , Cesario Flora , Borretta Giorgio

A regulatory role of the skeleton on glucose metabolism has been supposed both in animals and in humans. Osteocalcin (OC) seems to be involved in this regulation and has been reported to be inversely associated with insulin resistance and measures of adiposity in different populations of adult subjects. Primary hyperparathyroidism (PHPT) is a condition mostly affecting elderly subjects and characterized by both marked increased bone turnover and increased insulin resistance. T...

ea0020p230 | Bone/Calcium | ECE2009

Bone mineral density among patients with primary hyperparathyroidism with or without diabetes

Tassone Francesco , Gianotti Laura , Pellegrino Micaela , Baffoni Claudia , Ghio Michela , Emmolo Ignazio , Borretta Giorgio

Introduction: The relationship between diabetes mellitus (DM) and osteoporosis is controversial. Both Type 1 DM and Type 2 DM have been associated with higher risk of fractures, whereas BMD is increased in Type 2 and decreased in Type 1 DM. In primary hyperparathyroidism (PHPT) a higher prevalence of Type 2 DM has been found but the influence of DM on BMD is unknown.Subjects and methods: In a consecutive series of 262 patients with PHPT (age, mean±S...

ea0016p81 | Bone and calcium | ECE2008

Predictors of bone mineral density in men with primary hyperparathyroidism

Tassone Francesco , Gianotti Laura , Pellegrino Micaela , Croce Chiara , Baffoni Claudia , Magro Gianpaolo , Cesario Flora , Borretta Giorgio

Introduction: In primary hyperparathyroidism (PHPT) bone involvement is frequent. In women with PHPT it has been previously reported that menopausal status together with PTH, calcium levels and renal function are independent predictors of bone density. In male subjects, the impact of PHPT on bone status is less defined.Aim of the study: To investigate this study was possible predictors of bone mineral density (BMD) in a series of male subjects affected b...

ea0063p26 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

How do sex and BMI affect glucocorticoid treatment in adrenal insufficiency?

Puglisi Soraya , Tabaro Isabella , Cannavo Salvatore , Borretta Giorgio , Pellegrino Micaela , Chiappo Francesca , Pia Anna , Terzolo Massimo , Reimondo Giuseppe

Background and objective: Optimization of glucocorticoid (GC) replacement therapy in adrenal insufficiency (AI) is crucial to avoid consequences of under- or overtreatment. Dosing of GC replacement is mainly based on clinical grounds; however, the impact of patient’s characteristics on daily GC requirement is poorly evaluated. The aim of the study is to assess the influence of sex (M/F) and BMI on dosing GC in patients with AI of different etiology....

ea0056p1032 | Thyroid (non-cancer) | ECE2018

Thyroid disease in PHPT: a single centre study

Castellano Elena , Gianotti Laura , Latina Adele , Cesario Flora , Baffoni Claudia , Pellegrino Micaela , Tassone Francesco , Magro Giampaolo , Borretta Giorgio

Objective: Primary hyperparathyroidism (PHPT) and thyroid diseases are common in the general population. It is difficult to establish whether they occur in the same patient because of a direct relationship or just due to the widespread prevalence of both conditions. The reported prevalence of the concomitant occurrence of these two clinical conditions is widely scattered (ranging 17–84%), especially due to the heterogeneous criteria for patient selection. We aimed to eval...