Searchable abstracts of presentations at key conferences in endocrinology

ea0041gp8 | Adrenal | ECE2016

Adequate salt intake attenuates mineralocorticoid receptor antagonist-induced hyperkalemia in patients with primary aldosteronism

Fountoulakis Stelios , Papanastasiou Labrini , Piaditis George

Introduction: Mild hyperkalemia is a common side-effect of mineralocorticoid receptor antagonists (MRA), which can be precipitated by minimizing dietary salt intake. Restoration of salt intake can overcome diminished kaliuresis and restore potassium levels. Aim of this study was the evaluation of the effect of adequate salt consumption on plasma potassium levels in relation to the mean, maximum and minimum blood pressure (BP) in MRA-treated sodium-depleted hyperkalemic patient...

ea0032p470 | Diabetes | ECE2013

Monitoring and control of blood glucose levels in patients with inefficiently controlled insulin-treated diabetes mellitus through the utilization of an on-line telemonitoring system

Fountoulakis Stelios , Papanastasiou Labrini , Marakaki Chrisanthi , Anastasakou Marina , Piaditis George

Introduction: Our goal was to monitor and control the blood glucose levels in inefficiently controlled insulin-treated patients with diabetes mellitus (DM). The target was to achieve an early detection of DM deregulation, to maintain accepted HbA1c levels through active intervention and to minimize the outpatient department visits.Description of methods/design: Twenty-six insulin-treated type 1 and 2 DM patients were enrolled (mean age 61.42±14.5 ye...

ea0063p416 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

High prevalence of autonomous aldosterone secretion in patients with type 2 Diabetes Mellitus and arterial hypertension. The effect of SGLT2 inhibitors on renin-angiotensin-aldosterone system

Tyfoxylou Ernestini , Papanastasiou Labrini , Piaditis George , Voulgaris Nikolaos , Chrousos George , Kounadi Theodora

Introduction: The causes of arterial hypertension in diabetic and non-diabetic hypertensive patients are still not clear. However, in recent studies in non-diabetic hypertensive patients (NDHP) we observed dysregulation of aldosterone (ALD) secretion either in the form of autonomous secretion or as hyperesponse to stress. To the best of our knowledge, a similar study in hypertensive patients with type 2 Diabetes Mellitus (DHP) has not been conducted yet....

ea0063p620 | Diabetes, Obesity and Metabolism 2 | ECE2019

Next generation sequencing reveals ABCC8 (MODY 12) variants in two families with diabetes mellitus (DM)

Markou Athina , Sertedaki Amalia , Tatsi Elizabeth , Piaditis George , Kounadi Theodora , Kanaka-Gantenbein Christina

Introduction: Maturity Onset Diabetes of the Young (MODY) constitutes a genetically and clinically heterogeneous type of Monogenic Diabetes (MD). It is characterized by autosomal dominant inheritance, early onset diabetes, defect in the β-cell insulin secretion, positive family history, absence of diabetic ketoacidosis, auto-antibodies and insulin resistance. To date, 14 different MODY subtypes have been reported each one with distinct genetic etiology, however MODY patie...

ea0035p475 | Diabetes therapy | ECE2014

Improvement of HbA1c is blunted following discontinuation of an on-line telemonitoring system, in patients with inefficiently controlled insulin-treated diabetes mellitus

Fountoulakis Stelios , Papanastasiou Labrini , Malliopoulos Dimosthenis , Marakaki Chrisanthi , Markou Athina , Kounadi Theodora , Piaditis George

Aim: Primary goal was to determine whether the improvement of HbA1c, observed in inefficiently insulin-treated diabetes mellitus (DM) patients on a telemonitoring system, had a lasting effect following its discontinuation.Methods: Forty-seven DM patients (mean age 56.15±15.86 years, mean BMI 29.44±6.69 kg/m2, mean HbA1c 9.9±2.62%) and 25 insulin-treated matched controls (mean age 56.16±20.11 years, mean BMI 27.6±5.18 k...

ea0020p30 | Adrenal | ECE2009

Study of hormonal activity and insulin resistance in patients harbouring incidentally discovered bilateral adrenal adenomas

Androulakis Ioannis , Papanastasiou Lambrini , Tsenilklidi Ermioni , Prevoli Anastasia , Kafritsa Paraskevi , Pappa Theodora , Tsiavos Vaios , Piaditis George

Background: Hormonal activity and insulin resistance (IR) in patients with incidentally discovered bilateral adrenal adenomas (BA) has not been evaluated until now. Therefore, we have investigated cortisol and aldosterone secretion and IR in 29 patients with BA, in 113 patients with unilateral adrenal adenomas (UA) and in 89 healthy subjects (C).Methods: All subjects underwent the following investigation: 1) Low dose dexamethasone suppression test (LDDST...

ea0020p448 | Obesity and Metabolism | ECE2009

Evidence of increased cardiovascular risk in patients with non-secreting unilateral adrenocortical adenomas

Androulakis Ioannis , Kollias George , Markou Athina , Papanastasiou Lambrini , Angnostou Tilemachos , Papamichael Christos , Piaditis George , Kaltsas Gregory

Background: Incidentally discovered adrenal adenomas (AA) are associated with increased prevalence of hypertension, obesity, and impaired glucose tolerance, all established risk factors for cardiovascular (CV) morbidity. However, most studies were performed in patients with AA and autonomous cortsisol and/or aldosterone secretion, whereas the presence of cardiovascular risk in patients with non-secreting AA has not been looked into detail.Methods: Cardio...

ea0041gp23 | Adrenal (2) | ECE2016

Deterioration of indices of insulin resistance in patients with non-functioning and cortisol secreting adrenal incidentalomas during a long term follow-up

Papanastasiou Labrini , Alexandraki Krystallenia , Fountoulakis Stelios , Kounadi Theodora , Markou Athina , Tsiavos Vaios , Androulakis Ioannis , Samara Christianna , Piaditis George , Kaltsas Gregory

Introduction: Adrenal incidentalomas (AI) with or without concomitant autonomous cortisol secretion can be associated with several metabolic alterations that may lead to increased cardiovascular risk. However, data regarding insulin resistance (IR) during long term follow-up of AI are scarce. The aim was to prospectively investigate the presence and evolution of IR in patients with AI between 2003 and 2014.Methods: Seventy three patients with AI for at l...

ea0035p979 | Thyroid (non-cancer) | ECE2014

Ultrasound-guided thyroid fine needle aspiration with rapid on-site evaluation of adequacy: data from the clinic of endocrinology of a Greek tertiary general hospital in 2013

Fountoulakis Stelios , Papanastasiou Labrini , Koutmos Spiros , Charalambous Pinelopi , Stratigaki Aimilia , Panagouli Pelagia , Lazari Paraskevi , Asimis Eleptherios , Vlahou Melpomeni , Piaditis George

Introduction: Ultrasound-guided fine needle aspiration biopsy (US-FNAB) enables selective sampling of thyroid follicular cells while minimizing potential complications. Inadequate specimen sampling can lead to FNAB repeat. Our aim was to evaluate the morphological and cytological characteristics of thyroid nodules with US and rapid on-site evaluation of adequacy (ROSE).Methods: Two independent endocrinologists evaluated nodule characteristics of 171 US-F...

ea0070aep63 | Adrenal and Cardiovascular Endocrinology | ECE2020

Surgical outcomes of adrenalectomy for primary hyperaldosteronism after using novel diagnostic tests

Alexandraki Krystallenia , Markou Athina , Papanastasiou Labrini , Tyfoxylou Ernestini , Kapsali Chara , Gravvanis Christos , Kaltsas Gregory , Zografos Giorgos , Piaditis George

Background: Primary hyperaldosteronism (PHA) is the most frequent type of endocrine hypertension with a prevalence that is continuously rising. Following the introduction of diagnostic tests that consider both the adrenocorticotropic hormone effect andrenin–angiotensin–aldosterone system (RAAS), the post-dexamethasone saline infusion test (D-SIT) and the overnight dexamethasone, captopril, valsartan test (DCVT) using pharmaceutical RAAS blockade, a higher prevalenc...