Searchable abstracts of presentations at key conferences in endocrinology

ea0075p08 | Pituitary and neuroendocrinology | EYES2021

Indexes of chronic low-grade inflammation in different models of insulin-resistance: Evaluation of lipocalin-2 in metabolic sindrome, partial and total growth hormone deficiency

Bruno Carmine , Vergani Edoardo , Curro Diego , Pontecorvi Alfredo , Mancini Antonio

Lipocalin-2 (LCN2) is a glycoprotein synthetized by various cell types, including neutrophils, that acts as siderophores scavenger and play an important role in different chronic inflammatory processes. Metabolic Syndrome (MetS) and Adult Growth Hormone Deficiency (AGHD), both partial and total, are characterized by inflammatory features. The objectives of our cross-sectional study were: 1) to compare LCN2 levels in these clinical pictures; 2) to evaluate the relations between...

ea0075p10 | Pituitary and neuroendocrinology | EYES2021

Hormonal adjustment to metabolic derangement in adult Growth Hormone Deficiency: evaluation of Ghrelin and LEAP-2 serum level

Vergani Edoardo , Bruno Carmine , Curro Diego , Pontecorvi Alfredo , Mancini Antonio

Background: Ghrelin and its endogenous antagonist liver-expressed antimicrobial peptide-2 (LEAP-2) are involved in GH secretion, both acting on GSH-r1α, and regulation of glucose and lipids metabolism. Metabolic impairments are often accompanied by an upregulation of LEAP-2 expression, with a usual concomitant reduction in ghrelin secretion. Adult growth hormone deficiency (aGHD), characterized by weight gain, increased fat mass and insulin resistance, represent a conditi...

ea0081p229 | Thyroid | ECE2022

An innovative synthetic support for cytological and immunocytochemical assessment in cytologically indeterminate thyroid nodules. Feasibility study

Taccogna Silvia , Novizio Roberto , D'angelo Martina , Turrini Luca , Persichetti Agnese , Pontecorvi Alfredo , Papini Enrico , Guglielmi Rinaldo

Background: Fine needle aspiration (FNA) is the diagnostic procedure of choice in the evaluation of thyroid nodules. Nodules with indeterminate cytological categories, Tir3A and Tir3B according to Italian cytological classification, pose diagnostic challenges in clinical practice and are frequently submitted to diagnostic surgery. CytoFoam Core (CF) (Diapath, Martinengo, Italy) uses an absorbent foam device inserted into the needle hub to collect the cytological sample aspirat...

ea0081ep152 | Calcium and Bone | ECE2022

Teriparatide for hypoparathyroidism after bariatric surgery

Maggio Ettore , Morgante Cesare , Ramunno Vittoria , Corsello Andrea , Cera Gianluca , Pontecorvi Alfredo , Corsello Salvatore Maria

Background: Hypoparathyroidism is an endocrine disorder characterized by hypocalcemia due to low levels of parathyroid hormone (PTH). Activated vitamin D (calcitriol) and calcium supplementation may be difficult in patients with malabsorption, as calcium requires an acid environment to dissolve. In this setting, subcutaneous administration of PTH analogues may be effective in reducing the dosage of oral calcium and vitamin D supplementation.Case report: ...

ea0081ep755 | Pituitary and Neuroendocrinology | ECE2022

Pituitary adenomas and pregnancy: descriptive observational study

Veleno Miriam , Menotti Sara , Giampietro Antonella , Chiloiro Sabrina , Pontecorvi Alfredo , Marinis Laura De , Bianchi Antonio

Introduction: Pregnancy results in a significant change in pituitary gland size and function.Due to this physiological adaptation, management of pituitary adenomas during pregnancy represents a particularly complex challenge. Aim of this study was to focus on a single referral institution experience with special attention to this subgroup of patients: pregnant woman affected by pituitary adenoma.Materials and methods: This is a des...

ea0081ep953 | Thyroid | ECE2022

Risk of malignancy of indeterminate thyroid nodules: an Italian single-center cohort study

Cera Gianluca , Novizio Roberto , Corsello Andrea , Rossi Esther Diana , Locantore Pietro , Pontecorvi Alfredo

Background: In 2014 a new Italian classification system of thyroid cytology divided the indeterminate TIR3 category in two groups, TIR3A and TIR3B, aiming to reduce unnecessary thyroidectomies. The reported risk of malignancy is: TIR3A: <10%, suggesting follow-up and possible FNA repetition after 6 months, and TIR3B: 15-30%, recommending surgery.Objectives: We aimed to: evaluate the histological prevalence of malignancy in TIR3A and TIR3B nodules in ...

ea0063p434 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

A severe ACTH-dependent Cushing syndrome associated to a possible concomitant primary adrenal-dependent hypercortisolism: a challenging case

Paragliola Rosa Maria , Corsello Andrea , Cese Francesca Delle , Papi Giampaolo , Pontecorvi Alfredo , Corsello Salvatore Maria

Background: Cushing syndrome (CS) represents a challenging disease. The major difficulty is to distinguish between the two main etiologies of ACTH-dependent hypercortisolism. However, in rare cases, the concomitant presence of both an ACTH-dependent and a primary adrenal disease should be considered.Case report: We evaluated a 67-year-old woman for a severe ACTH-dependent CS (midnight serum cortisol 332 ng/ml; urinary free cortisol [UFC] 3000 mcg/day; co...

ea0049ep1426 | Thyroid (non-cancer) | ECE2017

A new strategy to estimate levothyroxine requirement after total thyroidectomy and radioiodine remnant ablation for ‘intermediate’ and ‘high’ risk differentiated thyroid cancer

Paragliola Rosa Maria , De Rosa Annapina , Di Donna Vincenzo , Papi Giampaolo , Pontecorvi Alfredo , Corsello Salvatore Maria

Introduction: The approach for initial thyroid hormone suppression in patients who undergo surgery for differentiated thyroid cancer (DTC), is based upon the risk of disease recurrence. In particular, recent American Thyroid Association guidelines suggest to maintain TSH levels between 0.1 and 0.5 mU/l and less than 0.1 mU/l for patients with ‘intermediate’ and ‘high’ risk respectively. The aim of the study is to identify the major predictive factors of LT4...

ea0041ep684 | Female Reproduction | ECE2016

Usefulness of dynamic Tsh evaluation for diagnosis of subclinical hypothyroidism in luteal deficiency

Mancini Antonio , Giacchi Elena , Saporosi Aurora , Olivieri Giulio , Di Segni Chantal , Marana Riccardo , Pontecorvi Alfredo

Introduction: It is known that thyroid disorders can influence menstrual cycle, but subclinical hypothyroidism (SH), as cause of ovulation disorders and luteal deficiency (LD) in particular,is underestimated. Monitoring women’s cycles, according to the Billings Ovulation Method (BOM), can allow a precise timing for hormonal evaluation and diagnose LD. Usually, a basal TSH value of 2.5 mg/ml is considered as cut-off for a good luteal function, but alone cannot identify all...

ea0032p23 | Adrenal cortex | ECE2013

Immunohistochemical markers of adrenal cortical tumors

Altieri Barbara , Fadda Guido , Capozzi Anna , Pontecorvi Alfredo , Casa Silvia Della

Introduction: Adrenocortical tumors (ACTs) are usually divided in adenoma (ACA) or carcinoma (ACC) according to histopathologic methods. Some lesions are occasionally difficult to classify according to these criteria. We studied the use of some immunohistochemical markers to recognise the difference between malignant and benign tumors.Materials and methods: We studied 12 patients affected by ACC and 10 by ACA. Clinical evaluation and hormone analysis wer...