Endocrine Abstracts

LCH is a rare proliferative histiocytic disorder, and it can infiltrate virtually any site in the body. Diabetes incipidus (DI) is the most common abnormality when there is involvement of the hypothalamic-pituitary axis (HPA). We have evaluated the anterior pituitary function and their responses to treatment in 9 patients (5M/4F; range 19–60 years) with proven LCH and DI. Endocrine evaluations consisted of clinical history, basal (GH, IGF-1, fT4, TSH, PRL, cortisol, LH, F...

Introduction: Thyrotropin-secreting pituitary adenomas (TSHomas) are a rare cause of hyperthyroidism and represent <1% of all pituitary adenomas. The majority of TSHomas (70%) secrete TSH alone, while mixed adenomas are not infrequent.Design: Herein, we reported the findings of six patients with TSHoma (mean age 44 yr, 4 female, 2 male). Mean TSH value was 15.1 mIU/L (3.3–38.0) who were followed-up in our department.Result...

A 41-year-old woman was admitted with headache and hypertension. She described worsening of headaches in the last 2 months. On physical examination blood pressure was 150/90 mmHg, and grade 1 hypertensive retinopathy was present. Her sister died at the age of 24 due to pancreas neuroendocrine tumour and her mother was followed up with multiple pancreatic cysts. Abdomen MRI revealed a 6 cm phaeochromocytoma lesion on the right surrenal and multiple cysts in the pancreas, kidney...

Introduction: The aim of this study was to evaluate the worth of the salivary cortisol after overnight 1 mg dexamethasone suppression test (DST) in different patients.Materials and methods: The patient groups of the study consisted of 18 Cushing’s syndrome patients, 12 patients with non-functional adrenal incidentaloma, 37 patients with obesity, 16 patients with hirsutism and 26 healthy control patients. Salivary cortisol (SC) and plasma cortisol af...

Propylthiouracil (PTU) is a widely used drug, and can cause drug-induced vasculitis which is characterized by inflammation and cellular infiltration of small vessels and presence of anti-neutrophil cytoplasmic antibodies (ANCA). We report a case of perinuclear antineutrophil cytoplasmic antibody-associated vasculitis developed during treatment with PTU for Graves’ disease. A 58-year-old woman admitted to the Emergency Department with painful necrotic lesion at her right e...

Clinical spectrum of phaeochromocytoma syndromes are very heterogeneous. Sometimes life threatening hypertensive attacks may be the presenting symptom or the clinical picture may be subtle that a nonspecific symptom like fatigue can lead to diagnosis. We herein present two phaeochromocytoma cases with distinct clinical features.Case 1: A 20-year-old female patient admitted to emergency department with blurred vision and headache. She experienced headache...

Oncogenic osteomalacia is a rare paraneoplastic syndrome, which can be associated with phosphaturic mesenchymal tumor or non-mesenchymal tumour. This tumour produces fibroblast growth factor 23 (FGF-23) that leads to subsequent hypophosphataemic osteomalacia. We, hereby present a patient with oncogenic osteomalasia who is misdiagnosed as ankylosing spondylitis. A 54-year old man with weakness, severe arthralgia involving pelvis, hip joints and lower extremities referred to the...

Primary hyperparathyroidism (PHP) during pregnancy is a very rare event that increases maternal and fetal morbidity and mortality. Complications during pregnancy or neonatal period have included spontaneous abortion, stillbirth, neonatal death, neonatal tetany.Management of maternal PHP diagnosed during pregnancy should be based on the patients’ symptoms and severity of the disease. Hyperparathyroidism characterized by progressive symptoms should be...

Ectopic ACTH syndrome (EAS) occurs in around 10% of all cases with ACTH-dependent hypercortisolism. The mean age of clinical presentation varies from 45 to 50 years, and most of them caused by intrathoracic neoplasm, and recognition of the disorder may be delay. Subsequently, it may be difficult to locate the ACTH source and manage the patients’ hypercortisolism. We present our patients with EAS from 2000 to 2007. Four patients, aged 15–43 years, two females and two ...

Pheochromocytomas are tumors capable of producing catecholamines and a variety of biologically active resulting in unusual clinical manifestations. We report the case of 18-year-old female with pheochromocytoma exhibiting fever of unknown origin. She had experienced continuous fever (ranging between 37.1–41  °C) and chills for previous several weeks. Antipyretics had been ineffective in lowering the body temperature and she was referred to our hospital when an a...