Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep153 | Calcium and Bone | ECE2021

Unexpected association of severe hypercalcemia and hypophosphatemia in a patient with chronic hypoparathyroidism: A case report

Vandi Giulia , Zavatta Guido , Repaci Andrea , Altieri Paola , Pagotto Uberto

Clinical vignetteA 65-year-old woman was hospitalized due to severe hypercalcemia (albumin-corrected calcium 16.9 mg/dl) associated with severe renal failure (creatinine 3.48 mg/ml), normal phosphate levels (3.9 mg/dl) and PTH < 5 pg/ml. Her past medical history included total thyroidectomy complicated by chronic hypoparathyroidism, for which she was followed by her primary care physician. One year before hospital admission, renal function was normal...

ea0081rc12.6 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Is Turner syndrome at risk for thyroid carcinoma?

Belardinelli Elisabetta , Dionese Paola , Cecchetti Carolina , Vicennati Valentina , Repaci Andrea , Pagotto Uberto , Gambineri Alessandra

Background: Many questions concerning Turner Syndrome (TS) remain unresolved, such as the long-term complications and, therefore, the optimal care setting for adults. Most controversials regard tumors. Very few data are available on thyroid carcinoma and no specific screening protocol of monitoring is advised in the current official guidelines. This long-term cohort study was primarily aimed at estimating the incidence and time to comorbid conditions along the life course, inc...

ea0063p502 | Calcium and Bone 2 | ECE2019

Evaluation of bone metabolism in women on aromatase-inhibitors before and after antiresorptive treatment

Vandi Giulia , Zavatta Guido , Repaci Andrea , Di Dalmazi Guido , Altieri Paola , Pagotto Uberto

Introduction: Adjuvant therapy with aromatase-inhibitors (AIs) increases bone loss and fracture risk. Concomitant antiresorptive treatment is currently recommended. The aim of this study was to evaluate the effects of AIs on bone metabolism and mineral density at 12 and 24 months.Methods: Among 400 women on AIs who attended our Endocrinology Unit from 2014 to 2016, we retrospectively evaluated those who initially refused antiresorptive and took cholecalc...

ea0022p40 | Adrenal | ECE2010

Higher cortisol response to glucose load in patient with adrenal adenomas and subclinical Cushing (SC)

Vicennati Valentina , di Dalmazi Guido , Casadio Elena , Repaci Andrea , Pagotto Uberto , Pasquali Renato

Aims: SC can be discovered in 5–20% of the incidentalomas. Subclinical secretion is defined by the failure to suppress plasma cortisol after 1 mg-overnight dexamethasone <50 nmol/l, but there is no agreement in literature. The aim of our study was to evaluate cortisol response to oral glucose tolerance test (OGTT) as potential marker of autonomous activity of these adenomas.Methods: Ninety subjects, 47 females and 43 males, underwent the protoco...

ea0014p259 | (1) | ECE2007

Prevalence of metabolic syndrome in a cohort of young Mediterranean women with polycystic ovary syndrome and association with clinical and biochemical parameters

Patton Laura , Gambineri Alessandra , Repaci Andrea , Forlani Giulia , Pagotto Uberto , Pasquali Renato

Aim: The purpose of the study was to evaluate the prevalence of the metabolic syndrome (MS) in a cohort of young Mediterranean women with PCOS in reproductive age and to evaluate the association of the MS with clinical and biochemical parameters.Setting: Among 200 PCOS (17-31 years) criteria of MS in accordance with the “NCEP-ATPIII” were used to construct 3 groups: no one criteria, 1 or 2 criteria and 3 or more criteria (affected by MS). All p...

ea0056p224 | Calcium &amp; Vitamin D metabolism | ECE2018

Clinical manifestation of Hypoparathyroidism in a monocentric cohort: our experience

Repaci Andrea , Altieri Paola , Dianori Francesco , Salituro Nicola , Vandi Giulia , Pagotto Uberto

Introduction: Hypoparathyroidism (HP) is characterized by low serum calcium and increased phosphate levels associated with inappropriately low serum PTH levels. Clinical manifestations of HP are tingling, muscle cramps, seizures, nephrocalcinosis, kidney stone, kidney failure, depression and anxiety.Objective: Quantify the chronic symptoms and complications of HP in our monocentric cohort.Material and methods: We conducted a retros...

ea0099oc10.1 | Oral Communications 10: Calcium and Bone | Part II | ECE2024

Time to severe chronic kidney disease and nephrolithiasis in hypoparathyroidism: results from a large longitudinal retrospective study

Piazza Anna , Bisceglia Nicolo , Malagrino Matteo , Altieri Paola , Repaci Andrea , Pagotto Uberto , Zavatta Guido

Introduction: Hypoparathyroidism (Hypo) is associated with a higher risk of chronic kidney disease (CKD) and renal stones, although the time to onset of these complications in the disease’s natural history has never been explored. Calcium-Phosphate product (CaxP) has been shown to be a risk factor for moderate renal disease in Hypo in a limited number of cross-sectional or case-control studies.Objective: To determine the time of onset of incident se...

ea0081p29 | Adrenal and Cardiovascular Endocrinology | ECE2022

The changing face of drug-induced adrenal insufficiency in the food and drug administration adverse event reporting system

Raschi Emanuel , Fusaroli Michele , Massari Francesco , Mollica Veronica , Repaci Andrea , Ardizzoni Andrea , Poluzzi Elisabetta , Pagotto Uberto , Di Dalmazi Guido

Importance: Adrenal insufficiency is a life-threatening condition complicating heterogenous disorders across various disciplines, with challenging diagnosis and a notable drug-induced component.Objective: To describe the spectrum and main features of drug-induced adrenal insufficiency through adverse drug event reports received by the Food and Drug Administration (FDA).Design: We conducted a retrospective disproportionality analysi...

ea0063gp18 | Calcium and Bone 1 | ECE2019

Calcium to Phosphorus (Ca/P) ratio as an accurate index for the diagnosis of primary hyperparathyroidism (PHPT) and hypoparathyroidism (HypoPT)

Vincentis Sara De , Repaci Andrea , Altieri Paola , Kara Elda , Vescini Fabio , Amadori Pierluigi , Balestrieri Antonio , Rochira Vincenzo , Madeo Bruno

Background: The diagnosis of PHPT and chronic HypoPT is still challenging, mainly due to the wide spectrum of clinical and biochemical presentation and the lack of validated diagnostic index in literature. The serum Ca/P ratio has been proposed as an accurate tool to diagnose PHPT in a small sample of patients, while no data is available about its possible application for HypoPT.Aim: To validate the serum Ca/P ratio as a diagnostic index for PHPT and to ...

ea0063gp110 | Calcium and Bone 2 | ECE2019

Denosumab in post-liver transplantation osteoporosis: preliminary data on the effects on bone mineral density and turnover markers

Zavatta Guido , Vandi Giulia , Di Dalmazi Guido , Repaci Andrea , Ravaioli Matteo , Cescon Matteo , Morelli Maria Cristina , Pagotto Uberto , Altieri Paola

Introduction: Several risk factors are involved in post-liver transplantation osteoporosis. Immunosuppressive agents, glucocorticoids, decreased renal function associated with secondary hyperparathyroidism and immobilization are the main determinants of fragility fractures in this population. Denosumab is highly effective in increasing bone mineral density (BMD) and preventing fragility fractures. However, the efficacy of denosumab in liver transplantation osteoporosis has nev...