Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep272 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Influence of nutritional status on clinical outcomes among hospitalized patients with covid-19

Keyla María Dotres Fallat , Nicolau Joana , Corao Luisa Ayala , Pilar Sanchís Cortés , Irene Rodríguez Rodríguez , Ana Gloria Soler Beunza , Romano Andrea Pompeo , Lluís Masmiquel Comas

Background and aimsSeveral factors that worsen the prognosis of the new coronavirus SARS-CoV-2 have been identified, such as obesity or diabetes. However, despite that nutrition may change in a lockdown situation, little is known about the influence of malnutrition among subjects hospitalized due to COVID-19. Our study aimed to assess whether the presence of malnutrition among patients admitted due to COVID-19 had any impact on clinical outcomes compared...

ea0070aep457 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Real-life clinical experience with GLP1 analogs and SGLT2 inhibitors in the treatment of diabetes type 2 and obesity

Pérez-Rodríguez José , Calderón-Vicente Dulce , González-López Javier , Martín-Iglesias David , Alramadan Mubarak

Objectives: SGLT2 inhibitors and GLP1 analogs are the treatment of choice after metformin in patients with type 2 diabetes (DM2) and overweight-obesity (OB). The aim of this study is to analyze the effectiveness and safety of these treatments alone or in combination.Methodology: This is a retrospective observational study in the usual clinical practice. We analyzed the effects of SGLT2 inhibitors and GLP1 analogs treatments in patients with DM2 and OB wh...

ea0070ep144 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Cardiovascular diseases in people with diabetes mellitus in asturias from 2013 to 2017

Sánchez Paula Morales , Escobedo Raúl Rodríguez , Iglesias Soraya Lanes , Felgueroso Carlos Alonso , Tames Gema Martínez , Menéndez Torre Edelmiro

Aim: Atherosclerotic cardiovascular disease, defined as myocardial infarction (MI), cerebrovascular accident (CVA), peripheral artery disease (PAD), is the main cause of morbidity and mortality in people with diabetes mellitus (DM) and the main cause of health expenditure in these patients.Like in other parts of the world, a prospective study of the Asturian population showed that the mortality risk due to cardiovascular diseases was significantly higher...

ea0014p120 | (1) | ECE2007

Ret expression reduces estrogen-induced lactotrope hyperplasia

Cañibano Carmen , Rodríguez Noela , Tovar Sulay , Vázquez María Jesús , Lavandeira Montserrat , Díeguez Carlos , Álvarez Clara

RET is a tyrosine kinase receptor activated by GDNF, NTN, ART and PSPN through GFRa1,2, 3 and 4 respectively. Activation of the receptor elicits intracellular pathways such us Ras/MAPK and PI3K/AKT leading to differentiation and proliferation. Our group has previously shown that RET is expressed specifically in the somatotroph cell population within the pituitary gland, both in rats and in humans. We have also shown that, in absence of its ligand GDNF, RET induces activation o...

ea0070aep361 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Autoimmune causes of hypoglycemia

Baraia-Etxaburu Marta , Álvarez Pilar , Vela Amaia , Monroy Jorge , Sáez de la Maleta Ruth , María Delgado Ana , Grau Gema , Rodríguez Amaia , Ruiz Enrique , Rica Itxaso

Background: Identifying the etiology of hypoglycemia in a non-diabetic patient is a significant challenge. Hyperinsulinemic hypoglycemia can lead to pancreatectomy in patients with no evident organic disease. Insulin autoimmune syndrome (IAS) or Hirata diseaseand Type B insulin resistance syndrome are the two typesof autoimmune hypoglycemia, with a low worldwide prevalence.Objective: We report two real-lifecases that illustrate each of them.<p class=...

ea0070aep993 | Thyroid | ECE2020

125I radioactive seed localization (RSL) in surgery of cervical metastasis of thyroid cancer

Jesús García González Juan , Martín Hernández Tomás , Domínguez Rabadán Rocío , Reyes Ravé García María , Rodríguez Vera Pablo

Introduction: The aim of this work is the evaluation of usefulness of radioactive seed localization (RSL) for the detection of cervical recurrence of thyroid cancer in order to improve the surgical outcome.Material and method: Six patients with thyroid cancer with cervical recurrences evidenced by ultrasound, cytology/Tg-FNAB were selected for this procedure. A 125I seed was placed in the metastatic lesion using a needle guided by ultrasound. ...

ea0014s19.4 | Pituitary cell biology | ECE2007

Adipocytokines and pituitary function

Malagon Maria M. , Rodríguez-Pacheco Francisca , Martínez-Fuentes Antonio J. , Vázquez-Martínez Rafael , Tena-Sempere Manuel , Diéguez Carlos , P. Castaño Justo

It is widely accepted that, in addition to serving as a repository for energy reserves, adipose tissue is an active endocrine organ that secretes a variety of signalling molecules, the adipokines, which play important roles in the regulation of metabolism, energy balance, feeding behaviour, vascular homeostasis and immunity. In particular, leptin, resistin and adiponectin have been implicated in energy and glucose homeostasis. Additional neuroendocrine functions have also been...

ea0014p314 | (1) | ECE2007

A novel pro-migratory action of TGFb in papillary carcinoma

Rodríguez García-Renueles María Elena , Bravo López Susan Belen , Seoane Rafael , Puig Carmen Gil , Teijeiro José Cameselle , Barreiro Francisco , Villamarín Clara Álvarez

Neoplastic thyroid diseases (multinodular goiter (MNG), follicular adenoma, differentiated (DTC) and undifferentiated thyroid carcinoma) have a higher incidence in women than in men. In fact, in the last ten years, DTC is the only cancer increasing the frequency in women, with an incidence similar to ovarian carcinoma or lymphomas.TGFb is a secreted factor important in the normal function of the thyrocyte. It has two independent actions: a fast antiproli...

ea0011p586 | Neuroendocrinology and behaviour | ECE2006

Clinical significance of macroprolactin

Álvarez-Vázquez P , Rodríguez Pérez D , Álvarez García E , Páramo Fernandez C , Hervás Abad E , Andrade Olivié MA

Introduction: Macroprolactin (maPRL) is a high molecular weight variant of prolactin (PRL) which has reduced bioactivity. The purpose of the present study was to determine the clinic-analytical repercussion of the presence of maPRL in patients with hyperprolactinaemia.Patients and methods: A polyethylene glycol (PEG) precipitation test was used to detect the presence of maPRL in all consecutive samples with prolactin levels >50 ng/ml (1060 mUIL). A r...

ea0073aep521 | Pituitary and Neuroendocrinology | ECE2021

Outcomes and complications of endoscopic pituitary surgery: A single-center study

Taibo Rocio Villar , Alicia Santamaría Nieto , Paula Andújar Plata , Antía Fernández Pombo , María Gemma Rodríguez Carnero , Ignacio Bernabeu Morón

ObjectivesTo present the results of our series of endoscopic surgery of PA, performed in a third level hospital by an experienced team.MethodsRetrospective review of PA undergoing endoscopic surgery between 2011 – 2018 in our institution. Clinical variables and radiological characteristics and outcomes were collected at diagnosis, before surgery and for an average of 4.8 years of postoperative follow-up....