Endocrine Abstracts

Introduction: The aim of our study was to investigate clinical and morphological features of dopamine agonist-resistant prolactinomas.Methods/design: The study included 51 patients (38 women, 13 men) with prolactin-secreting pituitary adenoma that is resistant to treatment with dopamine agonists, age 15–82 years.Results: Median of the serum PRL level distribution at the onset of the disease was 4500 mIU/l (3480, 140 300). The ...

Background: Managing hypoparathyroidism in patients with autoimmune polyendocrine syndrome type 1 (APS-1) poses significant therapeutic challenges. The presence of gastrointestinal candidiasis and associated malabsorption complicates treatment and may lead to refractory hypocalcemia. The use of high doses of calcium and active vitamin D metabolites to regulate serum calcium levels frequently results in hypercalciuria, which may cause long-term complications. Consequently, repl...

Aim: To present a clinical case of reversible hypopituitarism due to hypophysitis developed after COVID-19 infection.Materials and methods: A patient with residual clinical manifestations of hypopituitarism underwent clinical evaluation at the time of symptoms of hypopituitarism and in follow-up. Morning serum cortisol (171-536 nmol/l) was measured by electrochemiluminescence immunoassay. Morning ACTH (7.2-63.3 pg/ml), prolactin (66-436 mU/l), TSH (0.25-...

We report a 53-year-old man. At age 3, the patient was diagnosed with chronic mucocutaneous candidiasis. At age 41 the patient started losing all hair on the body with total boldness. At age 43, he first complained of muscle weakness resulting in difficulty walking, back pain and difficulties holding his head in an upright position. At age 49, he was diagnosed with chronic primary adrenal insufficiency and hypoparathyroidism. Genetic analysis confirmed APS-1 (c.769C>T p.R2...

According to numerous studies, type 2 diabetes mellitus (T2DM) is associated with an increased risk of low traumatic non-vertebral fracture. There are a limited number of studies which evaluate lateral vertebral X-Rays in order to diagnose vertebral fractures in patients with T2DM. The goal of our study was to investigate the difference in vertebral fracture rate registered on lateral X-Ray between subjects with T2DM and a control group being under observation in the same outp...

Objective: Pregnancy-related osteoporosis is a rare disorder with potentially severe complications. There is lack of clinical practice guidelines due to low incidence of this disease and few published cases.Material and methods: We present eight cases of pregnancy-related osteoporosis in women aged between 28–42 years. Six of them were diagnosed between 1 month and 3 years postpartum and two were diagnosed in the third trimester of pregnancy. Most o...

According to state statistics service, Russia’s population in 2018 is more than 146.8 mil people. The total prevalence of acromegaly may range between 2.8 and 13.7 cases per 100,000 people and the annual incidence rates vary between 0.2 and 1.1 cases per 100,000 people (Lavrentaki A, et al. 2016). The epidemiological data for acromegaly in Russian population is lacking. The Russian hypothalamic and pituitary tumors registry was founded in 2004 and for 2018 it con...

This study estimates the recovery of bone mineral density (BMD), markers of bone remodeling and quality of life in patients with endogenous Cushing’s syndrome (CS) after 12 months of remission.Materials and methods: Twenty-one patients with CS were prospectively evaluated at active stage of the disease and after being in a full remission (substitutional therapy with hydrocortisone or normal 24 h urinary free cortisol (24 h UFC) and late-night cortis...

Introduction: The important aspect of vitamin D (vitD) sufficiency is the impact of chronic diseases and medications, which disturb the metabolism of vitD. Bone pathology is common in diseases of the endocrine system, so the determining the status of vitD in various endocrine diseases and comparing it to otherwise healthy controls is of particular interest.Materials and methods: The study included 16 patients with type 2 diabetes mellitus (T2DM), 23 pati...

Introduction: Copeptin is a proposed new diagnostic marker in differential diagnosis of diabetes insipidus as it is secreted in equimolar concentrations with vasopressin. Thus our aim was to assess diagnostic value of copeptin evaluation in patients with polydipsic-polyuric disorders.Materials and Methods: We’ve evaluated the copeptin (BRAHMS CT-proAVP Kryptor), sodium levels and blood/urine osmolality in 26 healthy volunteers (1M/25F, mean age 24.7...