Searchable abstracts of presentations at key conferences in endocrinology

ea0016p126 | Clinical cases | ECE2008

Failure of restrictive bariatric surgery -- sleeve gastrectomy -- in severe hypothalamic obesity secondary to Langerhans cell histiocytosis: a case report

Runkle Isabelle , Lecumberri Edurne , Matia Pilar , Rubio Miguel A , Sanchez-Pernaute Andres , Nieto Asuncion , Mediavilla Joaquin

Langerhans cell histiocytosis (LCH) is a rare disease often involving the hypothalamo-pituitary axis. Extreme obesity is frequent, but effective treatment is not. Malabsorptive bariatric surgery techniques are effective for weight loss in hypothalamic dysfunction. Laparoscopic sleeve gastrectomy (LSG) has recently emerged as a restrictive bariatric procedure to be used before biliopancreatic diversion or gastric bypass, thus reducing surgery-associated morbidity in particularl...

ea0056p36 | Adrenal cortex (to include Cushing's) | ECE2018

Hypoaldosteronism induced by trimethroprim: hyponatremia is frequent

Herraiz Lorea , Azcutia Ane , Santiago Alejandro , Miguel Paz de , Crespo Irene , Cuesta Martin , Jimenez Ines , Calle Alfonso , Runkle Isabelle

Introduction: Hypoaldosteronism is characterized by the development of hyperkalemia, but can also induce hypovolemic hyponatremia. Trimethroprim can cause hypoaldosteronism through mineralocorticoid resistance. That hypoaldosteronism can induce hyponatremia in absence of Addison’s disease has been questioned. We studied the electrolyte disturbances found following initiation of trimetroprim therapy.Material and methods: Retrospective, analytical. La...

ea0063p111 | Calcium and Bone 1 | ECE2019

The coincidence of primary hyperparathyroidism and primary hyperaldosteronism is not infrequent: a retrospective case analysis

Barrio Elvira , Ramos Elvira , Crespo Irene , Pallares Raquel , Pazos Mario , de Miguel Paz , Cuesta Martin , Jose Torrejon Maria , Calle Alfonso , Runkle Isabelle

Introduction: Primary hyperparathyroidism (PHP) has been postulated to be a cause of primary hyperaldosteronism (PHA). In fact, PTH receptors have been detected in aldosteronoma tissue. Hyperaldosteronism can also induce elevation of PTH levels, as increased circulating volume increases calciuria, with secondary elevation of PTH levels as serum calcium levels rise. We studied the prevalence of PHP in a group of patients diagnosed with PHA either following or simultaneously wit...

ea0063p649 | Interdisciplinary Endocrinology 1 | ECE2019

Polydispia can reveal underlying non-osmotic arginine-vasopressin secretion

Pazos Mario , Pallares Raquel , Cuesta Martin , Barrio Elvira , Ramos Elvira , Herraiz Lorea , Azcutia Ane , Miguel Maria Paz De , Runkle Isabelle , Calle Alfonso

Inroduction: Polydipsia -excessive oral intake of liquids, with/without thirst- can induce euvolemic hyponatremia. Adequate inhibition of AVP secretion induced by low plasma osmolality (POsm) is reflected in a urinary osmolality (UOsm) ≤100 mOsm/kg. However, increased fluid intake can also reveal underlying non-osmotic AVP secretion, induced by pain, nausea, and/or SIADH, with UOsm >100. Iatrogenic polydipsia is characterized by increased liquid intake without thirst...

ea0063p850 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Measurement of androstenedione levels in adrenal veins for calculation of the selectivity index in adrenal venous sampling

Miren Azcutia Ane , Angelica Herraiz Lorea , Gonzalez Natalia , Jurado Purificacion , Abad Maria , Cuesta Martin , Mendez Jose , Calle Alfonso , Jose Torrejon Maria , Runkle Isabelle

Introduction: Primary hyperaldosteronism (PH) is characterized by autonomous adrenal aldosterone (A) hypersecretion. Unilateral adrenalectomy is the treatment of choice, when adrenal vein sampling (AVS) indicates lateralization of A secretion. To assure that each adrenal vein (AV) has been correctly sampled, cortisol levels in each adrenal vein must be higher than in the inferior vena cava. The adrenal gland cortisol/vena cava cortisol ratio is referred to as the selectivity i...

ea0049ep900 | Neuroendocrinology | ECE2017

Hyponatremia predating the diagnosis of malignancy in oncological/hematological patients with SIADH

Crespo-Hernandez Irene , Cuesta-Hernandez Martin , Santiago-Perez Alejandro , Gomez-Hoyos Emilia , Ortola-Buigues Ana , Miguel-Novoa Paz de , Chafer-Vilaplana Joan , Calle-Pascual Alfonso , Runkle Isabelle

Introduction: Euvolemic hyponatremia (HN) caused by the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) can predate a diagnosis of malignancy. It is thus essential to accurately diagnose the etiology of HN/SIADH when detected.Methods: Retrospective, descriptive study of all 52 oncological/hematological malignancy patients diagnosed with SIADH in our Department between January 2011 and December 2016. HN was detected via computerized Prima...

ea0041ep38 | Adrenal cortex (to include Cushing's) | ECE2016

Moderate/severe Hypovolemic Hyponatremia with urinary sodium loss secondary to Hypoaldosteronism: analysis of 28 cases

Penso Rona , Ortola Ana , Amengual Angela , Crespo Irene , Ruiz-Gracia Teresa , Cuesta-Hernandez Martin , Gomez-Hoyos Emilia , Marcuello Clara , Calle Alfonso , Runkle Isabelle

Introduction: Hypoaldosteronism (HA), a cause of hypovolemic hyponatremia (HN) with urinary(U) sodium(Na) loss, is often underdiagnosed. We studied 28 patients with an episode of HA-induced moderate/severe hyponatremia.Methods: Retrospective 2012–2015. In all patients, Nadir(N) serum(S) Na <130 mmol/l (corrected for total proteins and glycemia), low internal yugular venous pressure, low ocular pressure. Addison’s Disease ruled (ACTH, cortis...

ea0041ep742 | Neuroendocrinology | ECE2016

How frequently can we predict failure of fluid restriction in SIAD? Results of a multicenter prospective audit

Cuesta Martin , Ortola Ana , Slattery 2David , Garrahy Aoife , Pascual Alfonso Luis Calle , Tormey William , de la Vega Isabelle Runkle , Thompson Christopher J.

Context: Fluid restriction (FR) is recommended as first line therapy for SIAD by both the European1 and the American guidelines2 for management of SIAD. Not all patients respond to FR however, and the American guidelines have identified clinical predictors of failure to respond to FR. These include 1.Urine osmolality (UOsm) >500 mOsm/Kg 2. Furst formula (ratio UNa+UK/pNa) > 1, and 3. 24 hour-urine volume<1500 mlObjective...

ea0041ep754 | Neuroendocrinology | ECE2016

The use of a specific protocol for initiation of tolvaptan therapy in mild/moderate euvolemic hyponatremia secondary to SIADH: not a single case of overcorrection

Amengual Angela , Ortola Ana , Crespo Irene , Penso Rona , Ruiz-Gracia Teresa , Gomez-Hoyos Emilia , Cuesta-Hernandez Martin , Santiago Alejandro , Calle Alfonso , Runkle Isabelle

Introduction: ESE guidelines state a risk for overcorrection of serum sodium levels (SNa) with vaptans. We present the results of our protocol for initiation of tolvaptan(TV) therapy in SIADH.Methods: Retrospective (2011–15). 86 patients with SIADH-induced mild/moderate hyponatremia received TV:7.5 mg day 1, ad-libitum liquids, no other Na-raising therapies. Conventional hospitalization (CH):66/86, day hospital (DH):20/86. Glycemia-corrected SNa det...

ea0037gp.03.05 | Adrenal (2) | ECE2015

Short-term blood pressure response to mineralocorticoid-receptor blockade in aldosteronisms: primary hyperaldosteronism vs aldosterone-associated hypertension/low-renin hypertension

Crespo Irene , Ruiz-Gracia Teresa , Ortola Ana , Gomez-Hoyos Emilia , Cuesta Martin , Barabash Ana , Saez-de Parayuelo Maria Victoria , Sanchez-Orta Marisol , Calle-Pascual Alfonso , Runkle Isabelle

Introduction: Some authors consider aldosteronism to be a spectrum, ranging from aldosterone-associated (or low-renin) hypertension (AAH) to primary hyperaldosteronism (PHA) due to bilateral adrenal hyperplasia. Thus, blood pressure (BP) response to mineralocorticoid-receptor blockade (MRB) could be similar.Methods: Retrospective analysis of 60 patients. Screening per Endocrine Society guidelines, positive screening: aldosterone (pg/ml) to direct-renin (...