Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep1057 | Thyroid (non-cancer) | ECE2016

Antithyroid arthritis syndrome

Paepegaey Anne-Cecile , Mavromati Maria , Chanson Philippe , Salenave Sylvie

The most frequent side effects of antithyroid drugs are skin reactions (6%), gastrointestinal effects (5%) and arthralgia (5%). Other complications such as antithyroid arthritis syndrome (1%), agranulocytosis (0.5%) and hepatitis (0.2%) occur rarely.We describe the case of a 20-year-old woman with Graves’ disease. Two weeks after the beginning of carbimazole therapy, she developed an urticarial reaction that led to discontinuation of treatment. Neve...

ea0081rc4.8 | Rapid Communications 4: Pituitary and Neuroendocrinology 1 | ECE2022

Impaired insulin secretion without changes in insulin sensitivity explains hyperglycemia in patients with acromegaly treated by pasireotide LAR

Wolf Peter , Dormoy Alexandre , Maione Luigi , Salenave Sylvie , Young Jacques , Kamenicky Peter , Chanson Philippe

Background: Pasireotide is a second line treatment for acromegaly. Besides the growth hormone (GH) lowering efficacy, clinical use is limited by side effects on glycemic control. The aim of this study was to evaluate longitudinal changes in beta-cell function and insulin sensitivity induced by pasireotide therapy in patients with acromegaly.Methods: We performed a retrospective study in 33 patients. Efficacy (GH and IGF-I concentrations; tumor size) and ...

ea0049ep966 | Pituitary - Clinical | ECE2017

Gender differences in real-life GH dosing patterns in adults with GH deficiency (AGHD): experience from a Registry in France

Borson-Chazot Francoise , Hacques Evguenia , Pascal-Vigneron Veronique , Salenave Sylvie , Villette Beatrice

Introduction: Usually GHD women require higher GH doses than males, especially those with exogenous oestrogens (guidelines). This fact was assessed in real-life practice in France.Methods: Data were from a Registry in 84 sites treating AGHD (Norditropin®) up to 5 years. Naïve patients did not receive GH 6 months before inclusion. Statistics were descriptive.Results: 328 patients (129 naïve) were included; mean age 49...

ea0041gp163 | Pituitary - Clinical (1) | ECE2016

Medical treatment of macroprolactinomas Escalation and de-escalation of dopamine agonist dose

Paepegaey Anne-Cecile , Salenave Sylvie , Kamenicky Peter , Young Jacques , Chanson Philippe

Background: Cabergoline (CAB) is the most effective dopamine agonist (DA) used for the treatment of macroprolactinoma. Few data on the dose of CAB necessary for achieving and maintaining normal prolactin (PRL) levels are available. We aimed to study these parameters in a large series of patients with macroprolactinomasMethods: We retrospectively analysed the clinical, biochemical and imaging features at diagnosis and the treatment response to CAB (dose n...

ea0032oc5.6 | Reproduction | ECE2013

INSL3 in 268 male patients with congenital hypogonadotropic hypogonadism (CHH): effects of different modalities of hormonal treatment

Trabado Severine , Maione Luigi , Sarfati Julie , Salenave Sylvie , Chanson Philippe , Brailly-Tabard Sylvie , Young Jacques

Context: Insulin-like peptide three (INSL3) is a testicular hormone, secreted by Leydig cells, during fetal life, in newborns, and after puberty. These 3 phases of testicular activation are impaired in CHH.Objective: To evaluate in a single center circulating INSL3 in a significant series of men with CHH in order to asses the consequences of pre- and postnatal gonadotropin deficiency, to specify the INSL3 regulation by gonadotropins and to evaluate the p...

ea0022oc4.4 | Adrenals | ECE2010

Combined anticortisolic therapy by metyrapone, ketoconazole and mitotane: an alternative to adrenalectomy in severe Cushing’s syndrome

Kamenicky Peter , Droumaguet Celine , Baudin Eric , Salenave Sylvie , Trabado Severine , Cazabat Laure , Chanson Philippe , Young Jacques

Context: Mitotane due to its adrenolytic action is highly effective in long-term management of ACTH-dependent Cushing’s syndrome (CS). However, the slow onset of its anticortisolic effect makes its use problematic in severe CS, when very rapid therapeutic response is required. Association with metyrapone and ketoconazole, rapidly acting steroidogenesis inhibitors, could warrant CS control while waiting for the full efficiency of mitotane and thus avoid urgently performed ...

ea0056p741 | Growth hormone IGF axis - basic | ECE2018

IGF1 level and GH dose adjustmentin adults with GH deficiency (AGHD): experience from a Registry in France

Borson-Chazot Francoise , Pascal-Vigneron Veronique , Salenave Sylvie , Hacques Evguenia , Villette Beatrice

Objective: IGF1 is the most useful serum marker for GH dose titration in adults. The authors focused on the GH dose adjustment with extreme IGF1 values (<−2S.D.; >+2S.D.).Methods: French observational study of AGHD patients treated with Norditropin®.Prospective follow up until 5 years.Results (median [Q1; Q3]):: 328 AGHD, 39.2±14.3 years old wer...

ea0090p572 | Calcium and Bone | ECE2023

Similarities and differences between thyroid and parathyroid nodules on ultrasound: the PARATH-US study

Yazgi Dolly , Richa Carine , Salenave Sylvie , Kamenicky Peter , Bourouina Amel , Clavier Lorraine , Young Jacques , Chanson Philippe , Maione Luigi

Context: Cervical ultrasound is a frequently used and an accessible operator-dependent tool, which contributes to the characterization of thyroid nodules and to the preoperative localization of pathological parathyroid glands. However, thyroid nodules may be confused with parathyroid lesions. There is no study directly comparing thyroid and parathyroid nodules on ultrasound.Objectives: 1) To describe the ultrasonographic characteristics of parathyroid le...

ea0063p308 | Reproductive Endocrinology 1 | ECE2019

Reproductive phenotype in 265 men with congenital hypogonadotropic hypogonadism and 531 men with acquired hypogonadotropic hypogonadism: a monocentric comparative study

Maione Luigi , Sarfati Julie , Bernard Valerie , Gonfroy Celine , Jublanc Christel , Salenave Sylvie , Trabado Severine , Chanson Philippe , Young Jacques

Context: Hypogonadotropic hypogonadism (HH), defined by LH and FSH deficiencies, lead to impairment in testicular growth, testicular hormonal secretions and spermatogenesis. HH can have a prenatal (congenital HH, CHH) or post-natal (acquired HH, HHA) onset. Direct comparison of reproductive phenotypes (RP) between CHH and AHH has not been systematically performed in large series representative of these two populations.Patients and methods: 60 normal men,...

ea0022p530 | Male reproduction | ECE2010

Congenital hypogonadotropic hypogonadism in men as a cause of estradiol deficiency

Trabado Severine , Maione Luigi , Salenave Sylvie , Baron Stephanie , Galland Francoise , Sinisi Antonio-Agostino , Brailly-Tabard Sylvie , Young Jacques

Context: Congenital hypogonadotropic hypogonadism (CHH), is a rare disorder associated with severe testosterone deficiency and with impaired bone mineral mass (BMM) acquisition and osteoporosis. Estradiol (E2) play a major role in bone development and maintain in BMM in humans.Objective: To evaluate in detail the degree of E2 deficiency in adult men with CHH.Design and patients: Using a sensitive E2...