Endocrine Abstracts

Background: Sodium-glucose cotransporter-2 (SGLT-2) inhibitors were recently approved as adjunctive treatment for type 1 diabetes (T1D), contributing to better glycemic control, cardiovascular and renal protection. Aim: access the efficacy and safety of these antidiabetic agents in selected T1D patients.Methods: Evaluation of medical records of T1D patients starting SGLT-2 inhibitors between August 2018 and October 2019.Results: 24...

Introduction: Mammary duct ectasia (MDE) is an inflammatory breast disease characterised by dilation of major ducts and periductal inflammation. MDE occurs commonly in women undergoing menopause. The etiology has not been well defined but previous studies described an association between high prolactin and MDE.Case Report: A 42-year-old female was admitted to our hospital with complaints of galactorrhea, amenorrhea, mammary gland tenderness and breast di...

Objective: Graves’ disease (GD) occurs as a result of genetic and environmental factors that trigger autoimmunity. Some pro-inflammatory cytokines have already been linked to an increased susceptibility of developing GD. Recently, it has been reported that Covid-19 infection and SARS-CoV-2 vaccination trigger the emergence of new GD cases or disease recurrence as environmental factors due to the pandemic. However, there is no data in the literature reporting the effects o...

Introduction: It has been shown with many studies that sulphonylureas may have a negative effect on parameters of insulin resistance while improving glucose regulation. However not all of the sulphonylureas have the same effect. This analysis assessed the different effects of sulphonylureas on some metabolic parameters of insulin resistance.Method: Newly diagnosed 25 T2DM individuals who were naive of oral antidiabetic therapy were recruited and randomiz...

Introduction: Brown tumor refers to the skeletal change that develops as one of the complications of hyperparathyroidism, in which cystic and fibrous changes occur in the bone. It occurs in approximately 10−20% of patients with primary hyperparathyroidism. Parathyroid cancer is a rare cause of primary hyperparathyroidism and accounts for approximately 1% of cases. In some cases, hyperparathyroidism may be asymptomatic until it becomes a pathological fracture and may be t...

Introduction: Hemichorea-hemiballismus, secondary to hyperglycemia, is a rare but easily treatable condition that is usually associated with poorly controlled type II diabetes mellitus. Diagnosis is based on clinical assessment and imaging. Etiology includes primarily cerebrovascular diseases, metabolic, degenerative, infectious diseases, space-occupying lesions, basal ganglia damage due to drugs and toxic substances.Case: Here we report a rare case of a...

Carotid artery intima-media thickness (CCA-IMT) highly correlates with cardiovascular events in type 2 diabetes (T2DM). We aimed to determine the cardiovascular mortality and morbidity incidence regarding CCA-IMT and Framingham Score compared with preceding results of T2DM individuals. Our aim was to determine whether ultrasonographic evaluation of carotid arteries may predict cardiovascular mortality, morbidity and diabetic complications in T2DM patients.<p class="abstext...

Introduction: Adrenocortical carcinoma (ACC) is a very rare entity with a variable clinical presentation.Objective: To review the casuistry of ACC in our center in the last 15 years and to assess clinical characteristics and evolution in our patients.Material and method: We searched cases of ACC from 2004 to December 2018 registered in the Pathology Department.Results: Fifteen cases were found, 9 women and 6 ...

Introduction: Adrenal vein sampling (AVS) is the gold standard test to distinguish between unilateral adenoma and bilateral hyperplasia in primary hyperaldosteronism. This is a technical complicated procedure with a variable success rate. Our aim was to report our 10-year-success rate and results as regards to this procedure.Material and Methods: Retrospective observational study including data from patients undergoing AVS between 2009 and 2019.<p cl...

Although Diabetic ketoalkalosis (DKAlk) has beendescribed as a mixed acid-base disorder over half a century ago, there is unawareness among physicians. Here, we present two cases to emphasize DKAlk which is more common than it’s thought.Case-1: A thirty-year-old female patient with type-1 diabetes and ten weeks of pregnancy presented with several weeks of vomiting. She also reported that she had hyperthyroidism for 2 weeks and that she used propylt...