Searchable abstracts of presentations at key conferences in endocrinology

ea0037s10.3 | Thyroid and autoimmunity | ECE2015

Thyroid, selenium and autoimmunity

Schomburg Lutz

The trace element selenium (Se) is unevenly distributed in our earth’s crust causing regional differences in soil Se concentrations. Soil Se directly affects plant Se content and thereby animal and human Se intake. Besides intake, the actual health status and genotype modify Se metabolism and expression of selenoproteins, i.e., Se status. In order to assess the individual Se status, total blood Se concentration or two circulating selenoproteins are determined. According t...

ea0041oc8.5 | Thyroid - Translational | ECE2016

In vivo effects of repeated thyronamine (T0AM) administration in mice

Hofig Carolin , Harder Lisbeth , Sarsenbayeva Assel , Schomburg Lutz , Mittag Jens

Introduction: So far, only two representatives of thyronamines, namely 3-iodothyronamine (3-T1AM) and the iodine–free thyronamine (T0AM), have been detected in vivo. While intensive research is done on the (patho-) physiological function of 3-T1AM, the physiological role of T0AM is poorly studied. Conflicting data have been reported for the acute cardiac effects of T0AM. This project therefore determined whet...

ea0032p353 | Diabetes | ECE2013

Autoantibodies to the insulin- and IGF1-receptor in human sera

Welsink Tim , Schwiebert Christian , Minich Waldemar , Schomburg Lutz

Introduction: Autoantibodies (aAB) are characteristic of autoimmune diseases, but may also be found in apparently healthy individuals and precede pathological symptoms. We have recently reported on autoantibodies against the IGF1-receptor (IGF1R-aAB) in control subjects and patients with Graves’ disease (1). The isolated aAB were able to immunoprecipitate the recombinant autoantigen and antagonized IGF1 signaling in vitro. Given the structural similarities betwee...

ea0020oc5.2 | Thyroid: Basic and Clinical | ECE2009

Selenium and iodine determination from single murine thyroid lobes by TXRF-spectroscopy

Renko Kostja , Behrends Thomas , Stosnach Hagen , Kohrle Josef , Schomburg Lutz

Iodine (I) and selenium (Se) are two essential trace elements for regular thyroid gland functioning and thyroid hormone metabolism. Most Europeans are only marginally supplied with both elements through their daily nutrition. The mammalian organism has developed efficient and highly complex mechanisms to control I and Se uptake, metabolism and recycling. The thyroid gland is equipped with the necessary transporters and metabolizing enzymes for I uptake and bioconversion into t...

ea0020oc6.6 | Paediatric Endocrinology/Bone | ECE2009

Reduced selenoprotein P expression affects bone formation

Hog Antonia , Renko Kostja , Seemann Petra , Kornak Uwe , Schomburg Lutz

Selenium (Se) is an essential trace element and is important for maintaining health and preventing disease. Se exhibits its biological function as the 21st proteinogenic amino acid selenocysteine (Sec). Different cis and trans acting factors are necessary for incorporation of Sec into proteins. Se can be transported and stored as Sec in selenoprotein P (SePP), a liver-derived protein which contains up to 10 Sec residues per protein in humans. Thus, SePP functions...

ea0020p685 | Signal Transduction | ECE2009

On the importance of the selenium status for the inflammatory response

Stoedter Mette , Renko Kostja , Behrends Thomas , Schomburg Lutz

Many endocrine disorders bear an immunological component and involve local cytokines as paracrine signals. Moreover, certain auto-antibodies appear as causative pathological agents in some of the most common endocrine diseases e.g. in type I diabetes mellitus or different forms of autoimmune thyroid disease (AITD). Recently, selenium (Se) status and selenoproteins have emerged as important modifiers of the inflammatory response, AITD or sepsis. Notably, mortality risk of patie...

ea0016p221 | Diabetes and cardiovascular diseases | ECE2008

SelS/Tanis controls insulin sensitivity and is regulated by acute phase and diet

Stoedter Mette , Renko Kostja , Kohrle Josef , Schomburg Lutz

Background: Selenoproteins contain the 21st proteinogenic amino acid selenocysteine (Sec) and exert important biological functions. Selenoprotein S (SelS) has only recently been identified and appears to be implicated in type 2 diabetes and inflammation. In vitro studies have shown that SelS expression is controlled by circulating cytokine and glucose levels. Mechanistically, SelS participates in the retro-translocation during quality control in the ER and the ER-associ...

ea0016p353 | Growth and development | ECE2008

Impaired Se metabolism provokes gender-specific growth defects in mice

Renko Kostja , Chadt Alexandra , Michaelis Marten , Schweizer Ulrich , Al-Hasani Hadi , Kohrle Josef , Schomburg Lutz

Background: Selenoproteins are involved in oxidative stress defence, cell signalling and hormone metabolism. Accordingly, impairment of selenium (Se) metabolism or transport results in a complex phenotype as exemplified in selenoprotein P knockout mice (SePP-KO). This mouse model is characterized by a disrupted metabolism of Se resulting in neurological and growth defects. Hypothesis: Se impairs regular tissue development by modifying growth signal biosynthesis, anabolic respo...

ea0014p183 | (1) | ECE2007

Selenium supply modulates growth spurt of selenoprotein P knockout mice

Renko Kostja , Michaelis Marten , Schweizer Ulrich , Köhrle Josef , Schomburg Lutz

Background: Selenoproteins are playing an important role in body homeostasis and development. They control thyroid hormone metabolism and are of prime importance for intracellular redox regulation and cellular defence. The SePP knockout mouse (SePP-KO) is a model of impaired Se metabolism characterized by a disrupted distribution system for organified Se. One of the major phenotypes of the homozygote SePP-KO mice is a reduced increase in size and weight during the growth spurt...

ea0084ps2-09-86 | Thyroid Hormone ACTION | ETA2022

Quantification of CD5L as circulating marker of peripheral thyroid hormone action

Asaad Sabrina , Chillon Thilo , Minich Waldemar , Kuhnen Peter , Mittag Jens , Schomburg Lutz

The quantification of TSH from a serum or plasma sample constitutes the cornerstone of assessing the thyroid axis in the clinical routine. In addition, T4 and/or T3 levels may be determined to diagnose pathological conditions. However, these data do not necessarily reflect the local action of thyroid hormone in the target tissues and are sensitive to distortion, as best known from pregnancy when chorionic gonadotropin disturbs the regular feedback control. Recently, we identif...