Searchable abstracts of presentations at key conferences in endocrinology

ea0104p103 | Diabetes & Metabolism | SFEIES24

No effect of liraglutide, dulaglutide or danuglipron on in-vitro aggregation and activation of platelets from healthy subjects

Prem Kumar Anusha , Sreenan Seamus , Brennan Marian

Glucagon-Like Peptide 1 receptor agonists (GLP1RAs) have been shown to lower the risk of cardiovascular events and death in people with type 2 diabetes at high cardiovascular risk. Danuglipron, is a small molecule peptide agonist of the GLP1 receptor, a novel drug class of oral medication with promising effects on improving glycaemic control and promoting weight loss in people with diabetes or obesity. Due to the early cardiovascular risk reduction observed in some GLP1RA card...

ea0073aep65 | Adrenal and Cardiovascular Endocrinology | ECE2021

Nephrotic syndrome following resection of an adrenal incidentaloma: A case report

Batool Maria , Leen Eamon , Glavey Siobhan , Sreenan Seamus , Mcdermott John

A 69 year old man had a 5 cm right adrenal lesion discovered incidentally while being investigated for a deterioration in previously well-controlled hypertension. Routine investigations including serum albumin were normal. Further investigation confirmed a non-functioning adrenal lesion. MRI revealed a ’non-fat-containing T1 hyperintense indeterminate adrenal lesion with speckling of T2 hyperintensity, not typical for adenoma, hyperplasia, myelolipoma, haemangioma or pheo...

ea0073ep21 | Adrenal and Cardiovascular Endocrinology | ECE2021

Recurrence of ACTH-secreting bronchial carcinoid: a therapeutic challenge

Batool Maria , Young Vincent , Mcdermott John , Sreenan Seamus

A man presented at age 32 with clinical features of Cushing’s syndrome and biochemical investigations were consistent with ectopic ACTH. The only potential source on imaging was a 5 mm right lung nodule on chest CT but which was too small to biopsy. Medical therapy was not successful at controlling his Cushing’s features so he was referred for thoracotomy. Following lobectomy, the lung nodule was found to be a carcinoid tumour. Post operatively, the patient’s sy...

ea0041ep540 | Diabetes therapy | ECE2016

Impact of obesity on management of type 2 diabetes

Cheah Seong Keat , Duane Catherine , Durak Abigail , Sreenan Seamus , McDermott John , Tun Tommy Kyaw

Management of type-2 diabetes (T2D) should be individualised given recent increase in treatment options. There is a spectrum of phenotype of T2D from thinner patients who may be more insulin deficient to those who are overweight/obese and insulin resistant. We hypothesized that, if we are personalising treatment, thinner patients would be more likely to be treated with insulin secretagogues. To compare the management between these phenotypes, we reviewed 1007 patients with T2D...

ea0021p42 | Clinical practice/governance and case reports | SFEBES2009

Aetiology of hyperprolactinaemia

Sheehan Sharon , King Thomas , Woon Sze Ann , Rakovac-Tisdall Ana , McDermott John , Sreenan Seamus

Elevated serum prolactin (PRL) is common, with many potential causes. We performed a retrospective audit of patients with hyperprolactinaemia from 2006 to 2008, aiming to identify the clinical indications for prolactin testing, the aetiology identified and the treatment instigated. Medical notes for 83 patients (55 female, mean age 41 years (range 17–95)) with PRL >700 mU/l were retrospectively reviewed. Indications for testing included: seizure or suspected seizure (...

ea0073aep750 | Thyroid | ECE2021

Increasing levothyroxine requirements in a patient with previously stable hypothyroidism

Batool Maria , Cadogen Sinead , Kyaw Tun Tommy , Sreenan Seamus , Denton Mark , Mcdermott John

A 44 year old woman presented with leg swelling. Past history included hypothyroidism and ulcerative colitis treated with eltroxin (100 mg/day) and azathioprine (100 mg/day) respectively. Clinical examination revealed pitting oedema to knees and a ’puffy face’. Free T4 was 5.8 pmol/l (12–22 pmol/l), TSH 84.61 mU/l (0.27–4.20), serum albumin 24 g/l (40–49 g/l). She reported good compliance with L-thyroxine and no recent gastrointestinal symptoms. L-thyr...

ea0073ep67 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Boerhaave syndome and ’Diabetic Ketoalkalosis’ in a patient with type 1 diabetes mellitus: a case report

Batool Maria , Ni Chinneide Ashling , Tudor Roxana , Kyaw Tun Tommy , Sreenan Seamus , Arumugasamy Mayilone , McDermott John

A 20-year-old woman, with type 1 diabetes, presented to Emergency Department complaining of abdominal pain and vomiting for 3 days. She reported intermittent non-compliance with insulin therapy. Physical examination revealed epigastric tenderness. Blood glucose was 34.6 mmol/l, blood ketones 7.8 mmol/l, creatinine 131 µmol/l and CRP 31.47 mg/l (< 10). Despite clinical and initial laboratory features suggesting diabetic ketoacidosis, pH was 7.52 (7.32–7.43), pCO<s...

ea0104p96 | Diabetes & Metabolism | SFEIES24

A study of referral patterns and patient characteristics observed in Ireland’s first fully functional community hub diabetes service during its inaugural year of operation

de Jong Katie , Kyaw-Tun Tommy , McDermott John , Sreenan Seamus , Davenport Colin

Enhanced community care (ECC) for type 2 diabetes mellitus (T2DM) is a new initiative in Ireland. ECC involves episodic community-based consultant-led multidisciplinary care that supports general practitioner (GP)-delivered chronic disease management (CDM, available to patients with a medical or GP visit card). The Dublin North West (DNW) hub was the first fully operational hub. This study focuses on its inaugural year of activity. The study goals were to report on hub referra...

ea0015p230 | Pituitary | SFEBES2008

Spontaneous recovery from severe cardiac failure after acute hypotensive infarction of a somatotroph adenoma

Moran Carla , Davenport Colin , Behan Lucy Ann , Draman Mohd Shazli , King Thomas , Sreenan Seamus , Thompson Christopher , Agha Amar

Acromegalic congestive cardiac failure (CCF) is a serious and late complication of untreated acromegaly with associated high morbidity and mortality.1 Spontaneous recovery of end stage acromegalic CCF following autoinfarction of a somatotroph adenoma has not been previously reported.We report the case of a 61-year-old woman who presented with features of severe biventricular CCF and an acromegalic phenotype. Echocardiography revealed poor LV f...

ea0041ep1122 | Thyroid cancer | ECE2016

A study on age and nodule size in affecting decision for repeat thyroid FNAC after one benign cytology

Keat Cheah Seong , Pierce Brian , Kumar Anusha , Kyaw Tun Tommy , Sreenan Seamus , McDermott John , Hickey Neil , Leen Eamon , Sabah Muna , Walsh Thomas

Introduction: Fine needle aspiration cytology (FNAC) is a widely adopted pre-operative investigatory tool for thyroid nodules. The British Thyroid Association (BTA) recently updated guidelines recommending that an FNAC that initially yields benign cytology (Thy2) should be repeated if there is any clinical or ultrasound (US) suspicion (1). We postulate that there is a tendency for a more conservative approach in older age groups with smaller thyroid nodules on US studies.<...