Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp218 | Gestational and Type 1 Diabetes | ECE2019

Effect of HbA1c and hyperglycemia on hemostasis in patients with type 1 diabetes

Sarkisova Karina , Jarek-Martynowa Iwona-Renata , Shestakova Marina , Chirkova Lydia , Nikankina Larisa , Shamkhalova Minara

Background and aims: Hyperglycemia can be a risk factor for adverse cardiovascular and cerebrovascular events. However, changes in platelets and coagulation hemostasis during hyperglycemia have not been extensively studied. The aim of this study was to assess the impact of level of fasting plasma glucose, HbA1c on the platelet activity, the physiological anticoagulant activity and fibrinolysis in patients with Diabetes Mellitus type 1 (DM1).Ma...

ea0063p138 | Diabetes, Obesity and Metabolism 1 | ECE2019

Diabetic nephropathy and arterial stiffness in patients with type 1 diabetes mellitus

Sarkisova Karina , Jarek-Martynowa Iwona-Renata , Shestakova Marina , Shamkhalova Minara , Parfenov Alexander

Background and aims: In 2005, experts from the IDF assigned the risk of developing coronary heart disease in patients with type 1 diabetes mellitus (DM1) at age of 30 and over or patients with DM1 with kidney damage equal to the patients with type 2 diabetes mellitus. The need for a non-invasive preclinical marker for identifying patients with the increased risk of cardiovascular disease is obvious. The assessment of arterial stiffness can play a role of such marker. The aim o...

ea0049ep568 | Diabetes complications | ECE2017

Tubular and glomerular biomarkers of kidney injury on glucagon-like peptide-1 (GLP-1) therapy in type 1 diabetic patients

Zuraeva Zamira , Vikulova Olga , Mikhaleva Olga , Shestakova Marina , Ilyin Aleksandr , Shamkhalova Minara , Dedov Ivan

Background and aims: To evaluate the level of tubular and glomerular biomarkers of kidney injury as potential nephroprorotective effects of GLP-1R agonist (liraglutide) addition in type 1 diabetic patients compared to standard insulin therapy.Materials and methods: 12 T1DM patients with normo-(AER <20 mg/l, n=7) and microalbuminuria (AER<199 mg/l, n=5) with liraglutide 1.2 mg as add on to insulin for 6 month and 12 patients with...

ea0041gp86 | Diabetes (1) | ECE2016

Novel biomarkers of chronic kidney disease in diabetes

Zuraeva Zamira , Mikhaleva Olga , Vikulova Olga , Ilyin Aleksandr , Shamkhalova Minara , Shestakova Marina , Dedov I.I.

Background and aims: Microalbuminuria (MA) is not specific predictor of early stages of chronic kidney disease (CKD) in diabetes. We investigate several markers that might be useful in assessing early kidney damage in T1DM and T2DM patients additional to MA.Materials and methods: We examined 111 patients (T1DM/T2DM: 51/60) with AER<20 mg/l (n=80); <199 mg/l (n=18); ≥200 mg/l (n=13). Biomarkers of kidney damage (c...

ea0041ep484 | Diabetes complications | ECE2016

Association of the PPARG2 Pro12Ala, TNFα G(308)A and G(238)A, Lipc C(-514)T, Ace I/D, Slco1b1 Val174ala polymorphism with endothelial function and atorvastatin response in type 2 diabetic patients

Lebedeva Nadezhda , Vikulova Olga , Nikitin Alexei , Shamkhalova Minara , Shestakova Marina , II Dedov

Aim: To assess the association of the endothelial dysfunction (ED) parameters and the lipid-lowering response to atorvastatin therapy in patients with T2D with genetic markers of inflammation.Methods: We include 97 T2D patients with first prescribed atorvastatin 10–20 mg: M/F 26/71; mean age 57 years. After 12 month of statin therapy, patients had fasting lipid profiles and ED parameters repeated. For ED evaluation, we performed pulse wave analysis ...

ea0041ep541 | Diabetes therapy | ECE2016

PPARG2 Pro12Ala, TNFα G(308)A and G(238)A, LIPC C(-514)T, ACE I/D, SLCO1B1 Val174Ala polymorphism as predictors of lipid-lowering response to statin therapy in patients with T2DM

Lebedeva Nadezhda Ol , K Vikulova Olga , Nikitin Alexei G , Shamkhalova Minara Sh , Shestakova Marina V

Aim: To evaluate the effect of PPARG2 Pro12Ala, TNFα G(308)A and G(238)A, LIPC C(-514)T, ACE I/D, SLCO1B1 Val174Ala polymorphism on the response to statins therapy in patients with type 2 diabetes mellitus (T2DM).Methods: We consecutively recruited patients with type 2 DM requiring lipid-lowering therapy according to current guidelines. Patients were started on either atorvastatin 10 or 20 mg. After 12 month of st...

ea0035p489 | Diabetes therapy | ECE2014

Influence of different modes insulin on carbohydrate metabolism, state transplant, control of metabolic and hemodynamic factors in patients with type 1 diabetes during the 1st year after kidney transplantation

Glazunova Alexandra , Gracheva Svetlana , Biragova Margarita , Shamkhalova Minara , Shestakova Marina , Moysyuk Yan

Objective: To evaluate the impact of different modes of insulin therapy (continuous subcutaneous insulin infusion (CSII) using insulin pump or multiple insulin injections (MII)) on carbohydrate metabolism, the state of the transplant, cardiovascular system, calcium and phosphorus metabolism in patients with type 1 diabetes (DM1) during the 1st year after kidney transplantation (KT).Materials and methods: The study included patients with DM1 after transpl...

ea0056gp106 | Diabetes Translational | ECE2018

Transcranial duplexsonography in patients with type 1 diabetes and diabetic nephropathy

Sarkisova Karina , Jarek-Martynowa Iwona Renata , Martynow Mikhail , Tsagaeva Albina , Pyshkina Ludmila , Shestakova Marina , Shamkhalova Minara

Background and aims: Cerebrovascular reactivity (CVR) impairment was reported as a marker of cerebral microangiopathy in long-term type 1 diabetes (DM1). Indices of cerebral blood flow might serve as an indicator of early microangiopathic complications. The aim of this study was to evaluate CVR in patients with DM1 and diabetic nephropathy. Research design and methods: Study has been reviewed by the Local Ethics Committee. The study has been performed in accordance with ethica...

ea0073aep106 | Calcium and Bone | ECE2021

Mineral and bone disorders in patients after combined kidney-pancreas or kidney transplantation

Maganeva Irina , Larina Irina , Severina Anastasia , Aynetdinova Alina , Eremkina Anna , Shamkhalova Minara , Mokrysheva Natalia

BackgroundThe kidney or kidney-pancreas transplantation corrects many of the metabolic or biochemical abnormalities associated with chronic kidney disease (CKD); however, mineral bone disease (MBD) and cardiovascular pathology remain frequent in transplant recipients. This happens especially in patients who have long history of secondary hyperparathyroidism (SHPT), as well immunosuppressive therapy plays an important role in the progression of MBD.<p...

ea0049ep521 | Diabetes complications | ECE2017

Assessing the impact of ‘nephrogenic’ risk factors on the development of cardiac pathology in patients with long duration diabetes type 1

Arutyunova Margarita , Glazunova Alexandra , Klephortova Inna , Martynov Sergey , Manchenko Oxana , Ulianova Irina , Ilyin Alexandr , Shamkhalova Minara , Shestakova Marina

Aim: The aim of study is to investigate the effects of renal pathology on the cardiovascular system in patients with T1D, the detection of the most important cardiovascular risk factors associated with CKD.Methods: The study includes 156 patients with a long duration of T1D (more than 20 years): 24 patients without CKD, 82 patients with 1–4 stages of CKD, 29 patients on hemodialysis, 21 patients after kidney transplantation. In addition to the routi...