Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep677 | Obesity | ECE2017

Effects of mediterranean diet in obese patients with metabolic syndrome and depression

Dimitrijevic-Sreckovic Vesna , Janeski Hristina , Sreckovic Branko , Soldatovic Ivan , Nesovic Nevena , Vujovic Milica

Introduction: Central obesity is the source of inflammatory factors, causing endothelial dysfunction. In central nervous system, inflammatory factors mediate neurotransmitter metabolism promoting excitotoxicity and increase oxidative stress, and a major clinical symptom is depression. Mediterranean diet (MD) resulted as a good prevention method for depression.Aim: To examine the relationship of depression with abdominal obesity and metabolic syndrome (MS...

ea0049ep678 | Obesity | ECE2017

Visceral obesity in youth followed by decreased testosterone leading to erectile dysfunction and risk of early atherosclerosis

Dimitrijevic-Sreckovic Vesna , Janeski Hristina , Sreckovic Branko , Soldatovic Ivan , Pajovic Milica , Stojanovic Marko

Background: Abdominal obesity, which in fact is a metabolic syndrome (MS), is related to decreased testosterone, insulin resistance (IR), increased inflammatory factors, non-alcoholic fat liver disease (NAFLD) and risk of early atherosclerosis. Elevated inflammatory markers (CRP) may interfere with insulin signal transduction at the neuronal level inducing hypogonadotropic hypogonadism.Objective: To examine testosterone relationship with abdominal obesit...

ea0032p689 | Neuroendocrinology | ECE2013

Pituitary adenoma and associated tumors

Djurdjevic Sandra Pekic , Soldatovic Ivan , Doknic Mirjana , Miljic Dragana , Stojanovic Marko , Popovic Vera

Objective: It has been difficult to identify factors that affect the risk of cancer but we know that people are at higher risk as they get older, or have a strong family history of cancer. The potential influence of environmental and behavioral factors remains poorly understood.Aim: To study associations between PA and family history of malignancy in first-degree and second-degree relatives. As separate analysis, to study associations between PA patients...

ea0056gp7 | Acromegaly | ECE2018

Familial cancer clustering in patients with pituitary adenoma

Djurdjevic Sandra Pekic , Soldatovic Ivan , Doknic Mirjana , Miljic Dragana , Stojanovic Marko , Petakov Milan , Popovic Vera

Objective: People are at higher risk for malignancy as they get older or have a strong family history of cancer.Aim: To collect family history of cancer in a large cohort of patients with pituitary adenomas (PA) in Outpatient clinic from years 2005–2017.Results: Overall 46% of 1100 patients with PA had a family member affected with cancer. Breast cancer in family members was reported in 15.3% of patients with prolactinomas whi...

ea0049ep367 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Homocystein-significant marker of metabolic syndrome and atherosclerosis risk

Sreckovic Branko , Dimitrijevic-Sreckovic Vesna , Soldatovic Ivan , Janeski Hristina , Janeski Nenad , Gacic Jasna , Sumarac-Dumanovic Mirjana , Mrdovic Igor

Background: Obesity is followed by insulin resistance (IR) and low grade inflammation. In patients with metabolic syndrome (MS) and clinicaly evident vascular complications homocystein values are higher. Hyperhomocysteinemia correlates with hyperinsulinemia and IR, resulting in oxidative stress, which causes endothelial lesions and dysfunction, promoting atherosclerosis and hypertension.Objectives: To examine homocystein levels in patients with and witho...

ea0020p421 | Diabetes and Cardiovascular | ECE2009

Screening of the Romani population in Serbia for diabetes

Beljic Zivkovic Teodora , Zivkovic Rodoljub , Ignjatovic Toma , Marjanovic Milica , Soldatovic Ivan , Prgomelja Stela , Koprivica Branka , Ackovic Dragoljub

It is well known that Romani people suffer from respiratory and cardiovascular diseases. The aim of our study was to investigate the prevalence of diabetes in the Romani population in Serbia.Methods: During the period October 2006–May 2008, diabetes association of Serbia performed blood glucose measurements in 11 urban and 8 rural Romani communities in Serbia. Blood glucose values, name, age, presence of diabetes, family history for diabetes, time o...

ea0063p236 | Pituitary and Neuroendocrinology 1 | ECE2019

Serum aryl hydrocarbon receptor-interacting protein (AIP) levels are independent of serum GH levels both at baseline and in dynamic tests of GH stimulation and suppression

Stojanovic Marko , Wu Zida , Stiles Craig , Miljic Dragana , Soldatovic Ivan , Pekic Sandra , Doknic Mirjana , Petakov Milan , Popovic Vera , Strasburger Christian , Korbonits Marta

Background and aim: Aryl hydrocarbon receptor-interacting protein (AIP) is evolutionary conserved and widely distributed throughout organism. Broad interest for AIP comes from involvement of loss-of-function AIP mutations in pituitary adenoma pathogenesis. The role of AIP in normal pituitary function is largely unknown. AIP is co-localized with GH in somatotroph secretory vesicles. Serum AIP protein was proteomically identified. We aimed at investigating whether AIP and GH are...

ea0070aep737 | Pituitary and Neuroendocrinology | ECE2020

Body composition and bone mineral density in 107 patients with childhood onset growth hormone deficiency (CO-GHD) at the time of transition from pediatric to adulthood endocrine care

Doknic Mirjana , Stojanovic Marko , Milenkovic Tatjana , Zdravkovic Vera , Maja Jesic , Todorovic Sladjana , Katarina Mitrovic , Vukovic Rade , Miljic Dragana , Pekic Djurdjevic Sandra , Soldatovic Ivan , MilanPetako

Transition from childhood to adulthood is a vulnerable period in all adolescents and particularly inCO-GHD patients. Low bone mineral density (BMD) and body composition alterations are frequently reported in young adults with CO-GHD, but relevant large monocentric studies are lacking.Patients and Methods: In a monocentric, observational, retrospective cross-sectional study conducted from 2005–2019, 107 CO-GHD patients were analyzed (17–26 yea...

ea0056p748 | Neuroendocrinology | ECE2018

Metabolic status, body composition and bone mineral density in 85 patients with childhood onset growth hormone deficiency (COGHD) in transition period

Doknic Mirjana , Milenkovic Tatjana , Zdravkovic Vera , Jesic Maja , Todorovic Sladjana , Mitrovic Katarina , Vukovic Rade , Miljic Dragana , Pekic Sandra , Soldatovic Ivan , Stojanovic Marko , Petakov Milan

Transition from childhood to adulthood is particularly important in patients with COGHD mainly because of the associated metabolic abnormalities, inadequate body composition and decreased bone mineral density (BMD). There is a lack of large monocentric studies related to this issue.Design: Monocentric, observational, retrospective cross-sectional study.Patients: We collected 85 COGHD patients (58 males, aged 17–26 years) trans...

ea0056p821 | Pituitary - Clinical | ECE2018

Clinical relevance of metabolic phenotype in hypopituitarism: what really matters?

Miljic Dragana , Pekic Sandra , Doknic Mirjana , stojanovic Marko , Nikolic-Djurovic Marina , Medic-Stojanoska Milica , Milosevic Verica , Sosic-Jurijevic Branka , Ajdzanovic Vladimir , Jemuovic Zvezdana , Soldatovic Ivan , Popovic Vera , Petakov Milan

Previous studies reported increased prevalence of metabolic syndrome (MS) and mortality rates from cardiovascular causes in hypopituitary patients. Fatty liver disease was added recently to this unfavorable cardio-metabolic phenotype. We studied the prevalence of MS and non-alcoholic fatty liver disease (NAFLD) in unselected cohort of 282 hypopituitary patients (146 male), mean age 49.2±15.1 years, on standard replacement therapy (76.4% received l-thyroxin, 76% hydrocorti...