Endocrine Abstracts

A 16-year-old boy presented in September 2007 with headaches and droopy eye lid due to pituitary mass. His initial prolactin level was 320 832 mu/l which confirmed the diagnosis of macroprolactinoma.His glucagon test revealed him to be growth hormone deficient with normal thyroid function test and testosterone on the lower end of normal. He was then treated with cabergoline 0.5 mg once a week and growth hormone injection 0.8 mg once a day. In June 2008, his prolactin levels we...

Introduction: Obese adults of South Asian origin in the UK are considered to be obese at a BMI of 27.5 kg/M2 compared with 30 kg/m2 for other groups and are at increased risk of obesity related disorders such as type 2 diabetes. From July 2021, GPs have been offered financial incentives for referral of adults to weight management services. However no provision or adjustments have been made for children and young people especially those of South Asian orig...

Introduction: Patients with diabetes have nearly twice the risk of depression compared to general population. Prolonged hypoglycemia can occur with insulin overdose and treatment involves correction of hypoglycemia with oral or intravenous glucose supplementation, with glucagon or octreotide in some cases. Glucocorticoids are not routinely administered but can be used as an adjunct in severe cases. We present a case of intentional insulin overdose in a young diabetic patient w...

Introduction: Prolactin is a multifunctional pituitary hormone. The effect of prolactin on platelet activation is not well understood. Prolactinomas are the most common type of pituitary adenomas, and they are medically responsive to dopamine agonists. Mean platelet volume (MPV) is a marker of platelet function and activation. The aim of this study was to evaluate MPV values before and 6 months of cabergoline treatment when normoprolactinemia was achieved.<p class="abstext...

Post operative hypocalcemia poses significant resistance to early discharge of total thyroidectomised patients. Our institute implemented a new protocol to give empirical calcium and vitamin D supplements since Jan 2012 to prevent symptomatic hypocalcemia and facilitate early discharge. 75 (88.24%) out of 85 eligible cases did not have significant or symptomatic hypocalcemia and can be discharged by within 1 day with only two (2.67%) patients being readmitted electively for si...

Background: While investigating hyperandrogenism in women, local laboratory policy dictates adult females with a serum testosterone of >3.5 nmol/l should be confirmed with an alternative method to exclude interference by cross-reacting substances. Patients who were on testosterone replacement or had a previous result in the same year were excluded. We explore the biochemical investigation of discrepant testosterone in females.<strong...

Somatostatin is a hormone and neuropeptide expressed in the pancreas, gastrointestinal tract, hypothalamus, and other tissues. It regulates directly the secretion of insulin, glucagon, many of the gastrointestinal hormones, and growth hormone. It is therefore surprising the somatostatin knockout (sst-ko) mice have a very mild phenotype. We subjected sst-ko mice and heterozygous siblings which served as controls to a high-calorie diet, and confirmed that sst-ko mice gain weight...

Dehydroepiandrosterone (DHEA) has been a subject of controversy for more than a decade being called ‘a miracle hormone’, the ‘elixir of life’ and ‘an anti-aging supplement’. However, recent literature has proven mild to moderate benefit in selected group of patients. Data is mostly limited to primary adrenal failure patients with adequate glucocorticoid and mineralocorticoid replacement and in hypopituitarism from variable aetiology associated wit...

Introduction: 80–90% of insulinomas are smaller than 2 cm, equally located in the head, body and tail of pancreas. Computer tomography (CT) is 75%, magnetic resonance imaging (MRI) is 55–90%, endoscopic ultrasonography (EUS) is 85–95% and selective arterial calcium stimulation test (SACST) is 95–100% sensitive in the diagnosis of insulinomas. Here, we presented two cases of insulinoma which could not be located by conventional methods and evaluated with SAC...

Introduction: Hysterosalphingography (HSG) is the radiographic examination of uterine cavity and fallopian tubes. It is generally used during evaluation of infertility and radioopaque contrast is injected through cervical duct during the procedure. Lipiodol which is the most commonly used contrast media in HSG is a fatsoluble iodinated contrast media. This iodine is progressively cleared from the body in a period ranging from a few weeks to a few months. Here, we present a 6 w...