Endocrine Abstracts

Background: There are two types of thyroid nodule biopsy: fine-needle aspiration (FNAB) and core-needle (CNB). Multiple studies mainly from Eastern Asia demonstrate safety and efficacy of CNB, however it is very rarely used in Europe.Methods: Retrospective analysis of the first 281 CNBs performed in Romania, including 8 lymph nodes and 3 thyroid bed lesions. We used the Korean Thyroid Association reporting system (KTA-CNB) for histology reports.<p cl...

Fine-needle aspiration (FNA) is the best available technique for preoperative diagnosis of malignancy in thyroid nodules. Although its efficiency has been well described, the learning curve is underreported. We aimed to describe the learning curve of a new FNA facility (endocrinologist/pathologist) in a university based hospital.Methods: In February 2018 a new FNA facility was formed in our hospital comprising an endocrinologist with high experience in t...

Background: Medullary thyroid carcinoma (MTC) is a rare thyroid tumor (around 2% of thyroid cancers). Its prognosis is generally worse than for differentiated thyroid cancers. A very rare subset of MTC is described as encapsulated MTCs. To date, a limited number of case reports and case series have been published, and this type of tumor presents with no evidence of metastases even in case of very high levels of serum calcitonin.Case: A 33-year old pregna...

Introduction: Aggressive forms of papillary thyroid carcinoma are more commonly observed; anaplastic and poorly differentiated types are rarer, but have a higher death rate. The transformation from papillary to anaplastic is a rare occurrence; it is even more uncommon for a small region of well-differentiated thyroid cancer to occur alongside the anaplastic form in metastatic lymph nodes.Aim: We present a case of an aggressive form of papillary thyroid c...

Introduction: Hyperthyroidism and thyrotoxicosis can have multiple etiologies, varying from the most frequent described in clinical practice (Graves disease, toxic nodular goiter, thyroiditis) to very rare causes such as anaplastic thyroid cancer, thyroid lymphoma, amyloidosis or even secondary malignancy of the thyroid gland.Case report: A 53 year old man presented to our department for progressive goiter enlargement in the last two months which was acc...

Primary vaginal malignancy is uncommon, accounting for about 2% of all gynecological tract cancers, with small-cell neuroendocrine carcinoma of the vagina being exceptionally rare and aggressive. They display similar histological and immunohistochemical features to small-cell carcinomas of different origin. Few cases are reported in the literature so far and therefore, there is no current treatment protocol consensus. We report the case of a 34-year-old nulliparous patient, wh...

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare, autosomal dominant inherited syndrome caused by mutations in the MEN1 tumor suppressor gene and is characterized by the occurrence of parathyroid, pancreatic islet and anterior pituitary tumors. We present the case of a female patient known to have pituitary and parathyroid tumors in a MEN1 syndrome evolving for more than 20 years before associating pancreatic neuroendocrine tumor.Case r...

Introduction: Accessory thyroid tissue is a part of thyroid dysgenesis and sometime represents an incidental adult finding displaying a normal function.Material and Methods: This is a case presentation of an adult admitted for an atypical anterior cervical aspect which could not be recognized as accessory thyroid tissue only after surgery. Thyroid evaluation used imagery like ultrasound, computed tomography (CT), assays as TSH (Thyroid Stimulating Hormon...

Introduction: Synovial sarcoma represents a type of cancer derived from soft tissues; young males are more affected.Material and methods: This is a case report of a male with a cervical mass confirmed as sarcoma. Later on the investigations lead to the discovery of a thyroid nodule challenging the differential diagnosis. We assessed thyroid ultrasound, computed tomography (CT) at the cervical, thorax, mediastinum and abdomen; TSH (Thyroid Stimulating Hor...

Background: Adrenocortical oncocytoma is a veryrare adrenal tumor type, usually nonfunctioning and benign. Neurofibromatosistype 1 (NF1) is an autosomal dominant disease caused by mutations of the NF1 gene encoding neurofibromin, a tumor supressor gene that acts by activating a RAS GTP-ase which negatively regulates RAS activity. NF 1 is usually associated with pheocromocytoma, rarely with adrenal carcinoma, and no association with adrenal oncocytoma has been reported.<p c...