Searchable abstracts of presentations at key conferences in endocrinology

ea0059p128 | Neuroendocrinology and pituitary | SFEBES2018

Are silent corticotroph adenomas high risk tumours for recurrence? Systematic review and meta-analysis

Fountas Athanasios , Lavrentaki Aikaterini , Subramanian Anuradhaa , Toulis Konstantinos , Nirantharakumar Krishnarajah , Karavitaki Niki

Introduction: The 2017 WHO Classification of Pituitary Tumors grades silent corticotroph adenomas (SCAs) as high-risk adenomas due to their aggressive clinical behaviour (high probability of recurrence). Nonetheless, studies comparing recurrence rates of SCA with other non-functioning pituitary adenomas (NFPAs) subtypes have provided conflicting results necessitating review of the evidence this recommendation relies on.Aims: To estimate recurrence rates ...

ea0020oc3.1 | Reproduction/Stress/Endocrine Disruptors | ECE2009

Gapapentin for the treatment of hot flushes in women with natural or tamoxifen-induced menopause: a systematic review and a meta-analysis

Toulis Konstantinos , Tzellos Thrasivoulos , Kouvelas Dimitrios , Goulis Dimitrios , Tarlatzis Basil , Papadimas Ioannis

Context: Evidence suggests that gabapentin, a γ-aminobutyric acid analogue, is effective in the treatment of hot flushes in women with natural or tamoxifen-induced menopause.Objective and design: To investigate the efficacy and tolerability of gabapentin for the treatment of menopausal hot flushes, a systematic review of all pertinent trials and a meta-analysis of those that were randomized placebo-controlled (RCT) were performed.<p class="abste...

ea0020p634 | Reproduction | ECE2009

A systematic review and a meta-analysis on adiponectin levels in women with polycystic ovary syndrome

Toulis Konstantinos , Goulis Dimitrios , Farmakiotis Dimitrios , Katsikis Ilias , Georgopoulos Neoklis , Tarlatzis Basil , Papadimas Ioannis , Panidis Dimitrios

Background: Conflicting results regarding adiponectin levels in women with polycystic ovary syndrome (PCOS) have been reported. To evaluate adiponectin levels in PCOS, a systematic review of all studies comparing adiponectin levels in women with PCOS to healthy controls and a meta-analysis of those involving women with similar Body Mass Index (BMI) were performed. Influence of possible effect modifiers, such as insulin resistance (IR) and testosterone, was investigated. Influe...

ea0081p256 | Late-Breaking | ECE2022

Hobnail variant of papillary thyroid carcinoma, a systematic review and meta-analysis

Spyroglou Ariadni , Kostopoulos George , Bramis Konstantinos , Tseleni Sofia , Toulis Konstantinos , Mastorakos George , Konstadoulakis Manousos , Vamvakidis Kyriakos , Alexandraki Krystallenia

Background: Although papillary thyroid carcinoma (PTC) is considered to have an excellent prognosis, some more aggressive variants have been identified that show reduced overall survival rates. Besides from the diffuse sclerosing, tall cell, columnar cell, and solid variant, the hobnail variant was newly recognized as one of these aggressive forms, affecting recurrence, metastasis, and overall survival rates.Methods: We performed a systematic review and ...

ea0063gp188 | Adrenal and Neuroendocrine - Clinical | ECE2019

Increased risk of infections in Addison’s disease and congenital adrenal hyperplasia patients: a longitudinal study based on a United Kingdom primary care database

Tresoldi Alberto S , Sumilo Dana , Perrins Mary , Toulis Konstantinos A , Prete Alessandro , Reddy Narendra , Wass John A , Nirantharakumar Krishnarajah , Arlt Wiebke

Background: Primary adrenal insufficiency (PAI) can be of autoimmune origin (Addison’s disease, AD) or due to inborn disorders of steroidogenesis (congenital adrenal hyperplasia, CAH). Prognosis of patients with PAI has improved considerably after glucocorticoid replacement therapy became available. However, even in recent years, an increased risk of death has been described in both AD and CAH patients. Moreover, even with the current state-of-the-art replacement therapy,...

ea0032p75 | Bone and Osteoporosis | ECE2013

Calcium homeostasis in women with non-metastatic breast cancer with osteoporosis after a single-dose of denosumab: a pilot study

Mandanas Stylianos , Toulis Konstantinos , Mathiopoulou Lemonia , Margaritidou Efterpi , Georgopoulos Konstantinos , Boudina Maria , Chrisoulidou Alexandra , Pazaitou-Panayiotou Kalliopi

Introduction: Women with non-metastatic breast cancer form a distinct subpopulation in which calcium homeostasis in response to treatment with denosumab has not been extensively investigated.Methods: Female patients with osteoporosis, who were eligible for treatment with denosumab, were prospectively enrolled (2011–2012) and divided into two groups; Group A consisting of patients with either no history or benign diseases non affecting bone metabolis...

ea0056gp92 | Diabetes Epidemiology | ECE2018

Gestational Diabetes Mellitus is associated with increased risk of Non-Alcoholic Fatty Liver Disease: A population-based cohort study

Lavrentaki Aikaterini , Subramanian Anuradhaa , Thomas G Neil , Valsamakis George , Toulis Konstantinos , Daly Barbara , Mastorakos George , Tahrani Abd , Nirantharakumar Krishnarajah

Background: Gestational diabetes mellitus (GDM) is associated with adverse perinatal outcomes, and increased risk of post-natal type 2 diabetes and cardiovascular disease. However, whether GDM increases the risk of developing incident Non-alcoholic Fatty Liver Disease (NAFLD) is unclear and has not been well examined in previous studies. This is important considering the significant health burden of NAFLD and the opportunity to interfere in high risk population in order to red...

ea0063gp86 | Thyroid Nodules and Cancer | ECE2019

Benefits and limitations of TKIs in patients with medullary thyroid cancer: a systematic review and meta-analysis

Efstathiadou Zoe , Tsentidis Charalambos , Bargiota Alexandra , Daraki Vasiliki , Kotsa Kalliopi , Ntali Georgia , Papanastasiou Lamprini , Tigas Stylianos , Toulis Konstantinos , Pazaitou-Panayiotou Kalliopi , Alevizaki Maria

Tyrosine Kinase Inhibitors (TKIs) have been used in patients with advanced Medullary Thyroid Carcinoma (MTC). However, for some compounds, data on effectiveness and safety are limited. The aim of this systematic review and meta-analysis was to document clinical response and toxicities of TKIs in advanced MTC.Methods: A literature search in MEDLINE, EMBASE and Cochrane until May 2018 was performed for articles or abstracts on TKI use in MTC. Studies were ...

ea0063p833 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

The role of somatostatin analogs in the control of carcinoid syndrome: systematic review and meta-analysis

Alexandraki Krystallenia , Angelousi Anna , Chatzellis Eleftherios , Chrisoulidou Alexandra , Kalogeris Nikolaos , Kanakis Georgios , Savvidis Christos , Vassiliadi Dimitra , Toulis Konstantinos , Tsagarakis Stylianos , Kaltsas Gregory

Introduction: Somatostatin analogues (SSAs) are the mainstay of treatment for carcinoid syndrome (CS)-related symptoms. Controversy still exists regarding the extent of the efficacy of this intervention. The purpose of the systematic review and meta-analysis was to evaluate the percentage of patients achieving partial (PR) or complete response (CR) with the use of SSAs (lanreotide, octreotide, pasireotide) in patients with CS. Due to lack of uniformity and established criteria...