Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep602 | Endocrine-Related Cancer | ECE2022

Ectopic Cushing's syndrome due to metastatic lung carcinoid presenting on a background of DIPNECH

Moreno Telma , Ribeiro Sara , Varela Ana , Freitas Paula , Carvalho Davide

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a relatively recent and rare disease, frequently misdiagnosed. It is characterized as a generalized proliferation of pulmonary neuroendocrine cells and is recognized as a precursor lesion for pulmonary neuroendocrine tumors, although the risk of progression to malignancy is considered low. Here we report a patient with ectopic ACTH-dependent CushingÂ’s syndrome due to metastatic lung carcinoid tumors...

ea0090ep315 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Levothyroxine dosing following bariatric surgery – A 4-year follow up

Ribeiro Sara , Lima Bruno A , Goncalves Juliana , Moreno Telma , Ferreira Helena Urbano , Pedro Jorge , Varela Ana , Carvalho Davide , Freitas Paula

Introduction: The anatomical and physiological changes induced by bariatric surgery (BS) can significantly impact the absorption and pharmacokinetics of orally administered medication. In particular, levothyroxine (LT4) dosage, given its dependence on patientÂ’s weight and gastric pH for optimal absorption, is expected to change following BS. However, the literature is not unanimous and there is a void of longer-term studies. We aimed to compare LT4 dosage 4 years followin...

ea0016p567 | Obesity | ECE2008

Hyperandrogenism in pre- and post-menopausal obese women

Ferreira Joana , Souto Selma , Oliveira Ana , Freitas Paula , Correia Flora , Varela Ana , Carvalho Davide , Medina Jose Luis

Introduction: Obesity has been associated with increased androgenicity in women, however there are conflicting data on this subject. Objectives: To determine whether any androgen is independently related to body mass index (BMI), waist-to-hip ratio (WHR) or age. To access if there is an association between elevated plasma androgen levels and the presence of either morbid obesity or metabolic syndrome (MS).Design and Methods: A total of 148 obese women we...

ea0016p815 | Thyroid | ECE2008

Prevalence of primary hypothyroidism in an obese population

Souto Selma , Mesquita Joana , Oliveira Ana , Freitas Paula , Correia Flora , Varela Ana , Carvalho Davide , Medina Jose Luis , Braga D

A positive association between thyrotropin (TSH) secretion and body-mass index (BMI) was previously reported. There are many studies concerning thyroid function in obesity, and some of them describe higher TSH levels in obese subjects.Evaluation of the hypothyroidism prevalence in a sample of obese women in their first obesity appointment at Hospital São João.Anthropometric variables and serum levels of TSH, free triiodot...

ea0037ep561 | Obesity and cardiovascular endocrinology | ECE2015

The effect of the type of the bariatric surgery in the lipid profile: an age, sex, BMI, and excess weight loss matched study

Cunha Filipe , Oliveira Joana , Preto John , Saavedra Ana , Costa Maria , Magalhaes Daniela , Bettencourt-Silva Rita , Freitas Paula , Varela Ana , Carvalho Davide

Introduction: Bariatric surgery improves lipid profile. A still unanswered question is whether this improvement is merely weight dependent or also results from factors inherent to specificities of the bariatric procedure itself. We aimed to study lipid profile 1 year after bariatric surgery and compare its changes between the different procedures in patients matched for initial weight and for weight loss.Methods: We retrospectively analysed patients subm...

ea0022p244 | Clinical case reports and clinical practice | ECE2010

Polyuric-polydipsic syndrome after cranioencephalic traumatism in a patient with multiple sclerosis

Souto Selma B , Mesquita Joana , Alves Marta , Braga Daniel Carvalho , Varela Ana , Rodrigues Elisabete , Neves Celestino , Guerra Fernanda , Medina Jose Luis

Introdution: Central diabetes insipidus(CDI) is a rare disease, with multiple aetiologies such as cranioencephalic traumatism and multiple sclerosis (ME). However, the association with ME is not commonly described. The clinical suspicion must be made in the presence of polyuria and polydipsia.Case report: Woman, 67 years-old, revealing history of ME relapsing-remitting subtype with 8 years of evolution, hypertension and dyslipidemia, medicated with inter...

ea0022p433 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Pituitary adenoma mimicking a psychiatric disorder – a case report

Mesquita Joana , Joao Matos Maria , Varela Ana , Vinha Eduardo , Braga Daniel , Guerra Fernanda , Pereira Josue , Ayres Bastos Margarida , Castro Ligia , Carvalho Davide , Luis Medina Jose

Introduction: People with intracranial organic lesions, including pituitary tumours, may manifest initially as a psychiatric disorder, such as depression, emotional disturbance, anxiety, apathy, neurobehavioral disturbance, cognitive dysfunction and personality disturbance.Case Report: A male patient 45 years old was sent to the Department of Endocrinology of São João Hospital due to a pituitary macroadenoma. The patient referred asthenia, musc...

ea0020p503 | Obesity and Metabolism | ECE2009

Metabolically healthy but obese individuals

Mesquita Joana , Souto Selma , Varela Ana , Freitas Paula , Matos Maria Joao , Ferreira Miguel , Correia Flora , Braga Daniel , Carvalho Davide , Medina Jose Luis

Introduction: Obesity is a heterogenous disorder. One of its subtypes that has been recently described is termed the metabolically healthy, but obese (MHO) individuals. Preliminary evidence suggests that this could be due to lower visceral fat levels and earlier onset of obesity.Objectives: To determine the prevalence of MHO in a sample of obese patients. To evaluate whether body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) are...

ea0049ep719 | Obesity | ECE2017

Testosterone deficiency in obese males: is insulin resistance the one to blame?

Souteiro Pedro , Magalhaes Daniela , Pedro Jorge , Oliveira Sofia Castro , Neves Joao Sergio , Belo Sandra , Costa Maria Manuel , Bettencourt-Silva Rita , Varela Ana , Queiros Joana , Freitas Paula , Carvalho Davide , Group AMTCO

Introduction: Obesity is a growing worldwide public health issue and it is associated with multiple comorbidities, namely the so called Male Obesity-associated Secondary Hypogonadism (MOSH). However, the mechanisms that explain this association are not fully understood.Methods: Cross-sectional study of 163 obese men that were evaluated for several clinical and analytic parameters. Testosterone deficiency was defined as: total testosterone <2.8 ng/ml ...

ea0041ep793 | Obesity | ECE2016

Obstructive sleep apnoea syndrome – longitudinal outcomes and improvement predictors after bariatric surgery

Bettencourt-Silva Rita , Magalhaes Daniela , Souteiro Pedro , Sergio Neves Joao , Castro Oliveira Sofia , Manuel Costa Maria , Saavedra Ana , Bettencourt-Silva Marilia , Almeida Leonor , Drummond Marta , Queiros Joana , Varela Ana , Freitas Paula , Correia Flora , Carvalho Davide , AMTCO group Davide

Background: Bariatric surgery has been associated with a decrease in multiple obesity-related comorbidities including obstructive sleep apnoea syndrome (OSA). This study aims to access the OSA evolution in obese patients who underwent bariatric surgery.Methods: Retrospective longitudinal study of a population of obese patients who underwent bariatric surgery between January/2010 and July/2014 in our centre. Only patients who have undergone polysomnograph...