Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep108 | Bone and Calcium | ECE2020

Sequential treatment of osteoporosis: Our clinical experience

Michalska Dana , Zikan VIT

Backgroud: When considering treatment of patients with severe osteoporosis (after previously failed antiresorptive treatment) or patients with glucocorticoid–induced osteoporosis, it is suitable to choose treatment by teriparatide (TPTD, rhPTH 1–34). In contrast to long–term treatment by bisphosphonates (BP) or denosumab (DMAB), the treatment with TPTD increases the volume of trabecular bone and the thickness of cortical bone. The recommended length of treatm...

ea0022p121 | Bone/Calcium | ECE2010

The circadian rhythm of bone resorption: comparison between patients treated with teriparatide and patients with primary hyperparathyroidism

Luchavova Maria , Raska Ivan , Michalska Dana , Zikan Vit

Parathyroid hormone (PTH) has a biphasic effect on bone cells and can induce opposing responses resulting in both net bone loss and net bone formation. Patients with primary hyperparathyroidism (PHPT) lose the circadian rhythm for PTH and bone mass decreases. PTH administered intermittently resulting in increase in bone mass. We studied the differences in the circadian variability of bone turnover markers between women with PHPT and women with postmenopausal osteoporosis treat...

ea0099p454 | Calcium and Bone | ECE2024

The clinical presentation of primary hyperparathyroidism: effects of obesity and vitamin D deficiency

Zikan Vit , Hrdlicka Jan , Klimova Judita , Hana Jr Vaclav , Wagnerova Monika , Libansky Petr , Michalska Dana , Vlasakova Renata , Raska Jr Ivan

Our understanding of modifiable risk factors for developing primary hyperparathyroidism (PHPT) may support interventions to prevent the development of the disease or reduce its severity and deepen our insights into its pathogenesis. Obesity has been associated with elevated serum parathyroid hormone (PTH) in the general population and may also alter the clinical presentation in patients with PHPT.Objectives: The objectives of the study were to compare th...

ea0070aep721 | Pituitary and Neuroendocrinology | ECE2020

Septo-optic dysplasia with late-onset diagnosis: An uncommon presentation of a rare disease

Duarte Vitória , Ivo Catarina , Veríssimo David , Franco Sara , Bastos Filipa , Marcelino Mafalda , Vara Luiz Henrique , Portugal Jorge

Background: Septo-optic dysplasia (SOD), also known as de-Morsier syndrome, is a rare congenital disorder characterized by any combination of optic nerve hypoplasia, pituitary dysfunction and midline abnormalities of the brain. Clinical diagnosis requires the presence of at least two of the features. This disorder is equally prevalent in males and females, with a reported incidence of 1/10,000 live births. There is wide variation in the severity of the clinical features found....

ea0070ep269 | Endocrine-related Cancer | ECE2020

Multiple endocrine neoplasia: A case series of 7 families

Duarte Vitória , Ivo Catarina , Veríssimo David , Marcelino Mafalda , Vara Luiz Henrique , Franco Sara , Bastos Filipa , Manita Isabel , Raimundo Luisa , Portugal Jorge

Introduction: Multiple endocrine neoplasia (MEN) is a rare genetic syndrome characterized by occurrence of tumors involving two or more endocrine glands. Four types are described: MEN1, MEN2, MEN3 and the recently identi&#-1279;ed MEN4. Due to the complexity of the syndromes, it is difficult to manage these patients. Our objective was to describe the clinical features of individuals from 7 families with a diagnosis of MEN1 or MEN2 and identify current challenges in clinical pr...

ea0070ep499 | Thyroid | ECE2020

Endocrinopathies related to immune checkpoint inhibition: A clinical case presentation

Veríssimo David , Jácome de Castro Matilde , Ivo Catarina , Duarte Vitória , Marcelino Mafalda , Jácome de Castro João

Introduction: In the area of Immunotherapy, immunological checkpoints, such as CTLA-4, PD-1 or PD-L1, are membrane proteins involved in the immune response that, when inhibited, cause an increase in T cell activity and a consequent anti-tumor effect. However, this inhibition can also cause adverse effects, including endocrinopathies, such as thyroid dysfunction and hypophysitis.Clinical case: 59-year-old man, diagnosed with lung cancer, treated with nivo...

ea0073pep7.7 | Presented ePosters 7: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The impact of dipper profile on diabetes complications. A study of 197 diabetic patients

Duarte Vitória , Ivo Catarina , Veríssimo David , Silva Joao , Lopes Luis , Passos Dolores , Jácome Castro J , Marcelino Mafalda

BackgroundNon-dipping of nocturnal blood pressure is common among people with type 2 diabetes (T2D) and hypertension. Although the mechanism underlying the blunted nighttime response is unclear, insulin resistance is thought to play a role.AimsThis study aims to identify the pattern of nocturnal dipping of blood pressure in patients with T2D from a Portuguese population and its association with micro...

ea0073ep76 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Hepatogenous diabetes: is it real?

David Veríssimo , Ivo Catarina , Vitória Duarte , Silva Joao , Lopes Luis , Passos Dolores , J Jácome Castro , Marcelino Mafalda

IntroductionDiabetes mellitus (DM) due to cirrhosis is described as hepatogenous diabetes (HD). Despite being frequently described in the literature, it is not recognized as an entity by the ADA/EASD.Case reportWoman, 70 years old, previous history of autoimmune hepatitis with Child-Turcotte-Pugh A cirrhosis (CTP-A) since 2018, arterial hypertension and overweight (BMI 29.1 kg/m2). No personal or f...

ea0073ep86 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Bariatric surgery: a shift in metabolic control

David Veríssimo , Ivo Catarina , Vitória Duarte , Silva Joao , Lopes Luis , Passos Dolores , J Jácome Castro , Marcelino Mafalda

IntroductionObesity is a chronic disease that is associated with several comorbidities, decreased quality of life, and increased mortality rate. Bariatric surgery is the most effective therapy for obese patients with class III and class II with metabolic diseases. Its effectiveness is not only related to the weight reduction, but also to the improvement of the metabolic profile. The aim of this study is to characterize the effects of gastroplasty with Ro...

ea0070ep264 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Hearing complications in diabetes – A clinical case

Ivo Catarina , Duarte Vitória , Veríssimo David , Silva João , Costa Eurico , Lopes Luís , Passos Dolores , Matos Teresa , Jácome de Castro João , Marcelino Mafalda

Introduction: Malignant or necrotizing external otitis (MEO) is an invasive infection between external auditory canal and skull base. It is more frequent in elderly and in diabetic patients or with compromised immune system. As MEO advance osteomyelitis can developed. It is a severe and potential mortal complication of external otitis (EO).Clinical case: 78 years old man with history of type2 diabetes (good metabolic control) and right ear external otiti...