Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep76 | Adrenal and Cardiovascular Endocrinology | ECE2021

Quality of life in patients with classical form of congenital adrenal hyperplasia- deficiency of 21 hydroxylase

Vrbikova Jana , Jitka Prajsova , Dragomirecka Eva

Literary data concerning quality of life in adult patients with classical form of 21 hydroxylase deficiency (21 CAH) are sparse and discrepant. Our aim thus was to explore quality of life in a group of young adults with 21CAH attending regularly tertiary reference care centre. We used WHOQuOL Bref questionnaire and we administered it to 45 21 CAH patients of age 28.6 ± 8 yrs and we compared the results with the data from 111 age matched controls from healthy Czech populat...

ea0026p123 | Female reproduction | ECE2011

Self-reported health related quality of life and depression in women with polycystic ovary syndrome: associations with selected metabolic and hormonal PCOS features.

Vrbikova Jana , Hill Martin , Vankova Marketa , Kyrou Ioannis

Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age causing symptoms that can lead to depression and reduced health-related quality of life (HRQoL). Associations of depression and HRQoL indices with hormonal and metabolic PCOS features have not been adequately studied.Methods/design: Thirty-seven premenopausal women (age: 28±6.4 years; BMI: 28.3±7.2 kg/m2) with PCOS accord...

ea0022p326 | Diabetes | ECE2010

Pancreatic insulin secretion in women with polycystic ovary syndrome

Vrbikova Jana , Bilek Radovan , Vankova Marketa , Vondra Karel , Bendlova Bela

Aim: To study the insulin sensitivity and secretion in women with polycystic ovary syndrome (PCOS).Subjects and methods: Thirty-eight women with PCOS (age 26.1±4.1 years, BMI 20.9±2.0 kg/m2) and 81 control healthy women (age 25.8±5.2 years, BMI 21.1±2.3 kg/m2) underwent oral glucose tolerance test (OGTT). Insulin resistance was evaluated as oral glucose index (OGIS); Matsuda and HOMA-IR, insulin secretion was cal...

ea0022p762 | Thyroid | ECE2010

An increase in serum CA 19-9 leading to the discovery of thyroid cancer in patient with the history of rectosigmoid cancer

Vrbikova Jana , Trubac Miroslav , Adamek Svatopluk , Zeman Vladimir , Duskova Jaroslava

CA19-9 (sialyl Lewis[a] antigen) was originally described as a gastrointestinal system and pancreas specific tumour marker. Immunohistochemical studies have demonstrated that CA19-9 is expressed in both differentiated and anaplastic thyroid carcinomas. Increased serum levels of CA 19-9 were reported in few patients with anaplastic thyroid cancer; however, to the best of our knowledge, there is no previous report about serum levels of CA 19-9 in differentiated thyroid cancer. S...

ea0041gp12 | Adrenal (1) | ECE2016

Congenital adrenal hyperplasia (CAH) in adulthood

Vrbikova Jana , Frysak Zdenek , Cap Jan , Krcma Michal , Cifkova Renata , Lanska Vera

Background and aim: Up to now, there is paucity of studies concerning health status in adults with congenital adrenal hyperplasia (CAH). We aimed to examine a group of adult CAH patients from different Czech centers.Methods: Serum lipids, glucose, blood pressure and anhtropometrics were compared in 31 males and 71 females with CAH 21-hydroxylase deficiency and in healthy population from Czech post-MONICA study (1% random population sample).<p class="...

ea0022oc1.3 | Diabetes and obesity | ECE2010

NME7: a new candidate gene for T2DM

Vcelak Josef , Seda Ondrej , Vankova Marketa , Lukasova Petra , Vrbikova Jana , Tremblay Johanne , Bendlova Bela , Hamet Pavel

The identification of genomic determinants responsible for common multifactorial diseases like type 2 diabetes mellitus (T2DM) is facilitated in large families from relatively genetically-isolated populations and can extend results from GWS based on a case–control cohort to detect rare alleles with strong effects. In order to search for sequence variants conferring risk of T2DM we previously conducted a genome-wide linkage study in 108 French–Canadian families from t...

ea0022p352 | Diabetes | ECE2010

TCF7L2 gene variants and polycystic ovary syndrome

Vankova Marketa , Vcelak Josef , Lukasova Petra , Bradnova Olga , Prazakova Silva , Dvorakova Katerina , Vrbikova Jana , Bendlova Bela

Polycystic ovary syndrome (PCOS) is considered as a risk factor for diabetes type 2 (DM2), it is often associated with obesity, β-cell dysfunction or insulin resistance. Genetic factors underlying the association of PCOS with DM2 is unknown. Recent human genetic studies have revealed that transcription factor 7-like (TCF7L2) polymorphisms are associated with DM2 through modulation of β-cell function.The aim of this study was to test if <...

ea0020p10 | Adrenal | ECE2009

The cortisone to cortisol conversion in autoimmune Type 1 diabetes

Simunkova Katerina , Kriz Lubomir , Hill Martin , Vrbikova Jana , Hampl Richard , Zamrazil Vaclav , Janickova Denisa , Vondra Karel

The aim of the study was to obtain data about peripheral metabolism of cortisol.We compared diabetics with low response (LR), and with normal response (NR) during low dose ACTH test, and a control group (C).Twelve diabetics were investigated; LR (n=6), NR (n=6), age 44±10 year (mean±S.D.), age at diagnosis of DM1 28.5±10 year, disease duration 15±8 year, BMI 24.5±2.7 kg/cm2...

ea0020p667 | Reproduction | ECE2009

Selected cytokines are associated with markers of insulin resistance in polycystic ovary syndrome

Stanicka Sona , Vrbikova Jana , Haluzik Martin , Hill Martin , Dvorakova Katerina , Grimmichova Tereza , Vondra Karel

The polycystic ovary syndrome (PCOS) is associated with features of the insulin resistance syndrome and altered glucose homeostasis. Factors that play an important role in these processes are still emerging. Pro-inflammatory cytokines may be involved in development of insulin resistance in PCOS. The purpose of this study was to determine if a relationship exists between interleukin-6 (IL-6), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), hepatocyte growth fa...

ea0016p223 | Diabetes and cardiovascular diseases | ECE2008

Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide in polycystic ovary syndrome

Vrbikova Jana , Hill Martin , Vondra Karel , Bendlova Bela , Grimmichova Tereza , Dvorakova Katerina , Stanicka Sonja , Pacini Giovanni

Insulin hypersecretion during oral or intravenous glucose tolerance test (OGTT, ivGTT) was described previously in women with polycystic ovary syndrome (PCOS). Little attention was given to the regulation of insulin secretion in these subjects. We aimed to study the secretion of incretins (glucose-dependent insulinotropic polypeptide, GIP, glucagon-like peptide 1, GLP-1), during OGTT in normoglucose-tolerant PCOS women.After signing written informed cons...