Searchable abstracts of presentations at key conferences in endocrinology

ea0081p537 | Adrenal and Cardiovascular Endocrinology | ECE2022

Management of persistent subclinical hypercortisolism post left adrenalectomy in a patient with primary bilateral macronodular adrenal hyperplasia with aberrant receptors

Moustaki Melpomeni , Papadimitriou Kasiani , Papanikolaou Vasiliki , Cherolidi Eleni , Rigana Maria , Kyriakopoulos Georgios , Kalogeris Nikolaos , Vryonidou Andromahi

Introduction: Endogenous subclinical hypercortisolism occurs in 5-30% of patients with adrenal incidentalomas. Adrenal adenoma is the commonest cause of autonomous cortisol secretion (ACS), while primary bilateral macronodular adrenal hyperplasia (PBMAH) is rare. In both, ACS results from activation of the cAMP/PKA pathway. This may be triggered by ligands, other than ACTH, acting upon aberrant G-protein coupled receptors (GPCRs), which may also control locally produced ACTH i...

ea0081p723 | Thyroid | ECE2022

Metastatic papillary thyroid carcinoma without identifiable primary tumor in a patient with IgG4-related thyroiditis: challenging diagnosis and management of a rare case

Papadimitriou Kasiani , Moustaki Melpomeni′ , Tsitsimpis Anastasios , Papanikola Nektaria , Dermentzoglou Alexandros , Spanou Loukia , Vryonidou Andromahi

Introduction: IgG4-related thyroiditis (IgG4-RTD) is a rare fibroinflammatory disorder. It is characterized by dense lymphocyte infiltration (mainly IgG4+ plasma cells), enlargement and dysfunction of the thyroid gland. IgG4-RTD includes mostly cases of Hashimoto’s (HT) but also of Riedel’s and Graves’ thyroiditis. Diagnosis is set according to imaging and histopathological criteria. Papillary thyroid carcinoma (PTC) is the most common form of thyroid cancer (~9...

ea0081p248 | Late-Breaking | ECE2022

The differences between normocalcemic and hypercalcemic primary hyperparathyroidism: a tertiary center′s experience

Kalogeris Nikolaos , Papanikola Nektaria , Herolidi Eleni , Palioura Eleni , Papanikolaou Vasiliki , Loi Vasiliki , Vryonidou Andromahi

Introduction: Normocalcemic Primary Hyperparathyroidism is today considered a variant of Primary Hyperparathyroidism. It is characterized by persistently normal calcium levels and increased levels of parathyroid hormone, after the exclusion of other causes of secondary hyperparathyroidism. We aimed to compare clinical, biochemical and imaging data from patients with normocalcemic and hypercalcemic primary hyperparathyroidism. Methods: This is a retrospec...

ea0070aep226 | Bone and Calcium | ECE2020

The incidence of nephrolithiasis and osteoporosis in patients with asymptomatic hyperparathyroidism

Polymeris Antonis , Kalogeris Nikolaos , Lafkas Apostolos , Papanikola Nektaria , Herolidi Eleni , Kogia Christina , Vryonidou Andromahi

Introduction: The clinical profile of patients with primary hyperparathyroidism has changed significantly in the last decades considering the fact that most cases are asymptomatic. This could be attributed to early diagnosis due to routinely serum calcium measurement. Only 5–27% of patients present with symptoms or signs related to osteoporosis, nephrolithiasis and hypercalcaemia. However, in patients with asymptomatic primary hyperparathyroidism (APHP) data concerning t...

ea0073aep823 | Late Breaking | ECE2021

A case of euglycaemic ketoacidosis and concomitant acute pancreatitis in a diabetic patient treated with SGLT2i and GLP-1RA

Moustaki Melpomeni , Kalogeris Nikolaos , Katsafyloudi Maria , Papanikola Nektaria , Rigana Maria , Spanou Loukia , Angelopoulos Theodoros , Kalantzis Ioannis , Vryonidou Andromahi

IntroductionGlucagon-like peptide 1 receptor agonists (GLP-1RA) and sodium-glucose cotransporter-2 inhibitors (SGLT2i) are the two novel classes of anti-diabetic agents with compelling efficacy, in terms of glucose-lowering and cardio-renal protection. Euglycemic diabetic ketoacidosis (EDKA) is a serious rare adverse effect of SLT2i while the use of GLP-1RA has been scarcely linked with acute pancreatitis in humans.Case presentatio...

ea0067o56 | Oral Presentations | EYES2019

Effects of novel antidiabetic agents on the arterial wall elastic properties as a marker of vascular function in patients with type 2 diabetes mellitus

Stampouloglou Panagiota , Siasos Gerasimos , Bletsa Evanthia , Batzias Konstantinos , Paschou Stavroula A , Antonopoulos Alexis , Tsigkou Vasiliki , Oikonomou Evangelos , Gouliopoulos Nikolaos , Thanopoulou Anastasia , Noutsou Marina , Vryonidou Andromahi , Tentolouris Nikolaos , Tousoulis Dimitris

Background: Arterial stiffness is a well-established surrogate marker of vascular properties and arterial dysfunction in patients with type 2 diabetes mellitus (DM2). We aimed to investigate whether optimization of DM2 therapy with, additional to metformin, novel antiglycemic agents may improve arterial wall properties and achieve better glycemic control.Methods: We enrolled 99 consecutive patients (male gender=63.3%) receiving metformin for DM2 who did ...

ea0063p297 | Reproductive Endocrinology 1 | ECE2019

The natural course of normal weight women with polycystic ovary syndrome: an insight into metabolic changes of a large Caucasian cohort

Livadas Sarantis , Macut Djuro , Bothou Christina , Kuliczkowska-Płaksej Justyna , Vryonidou Andromahi , Bjekic-Macut Jelica , Mouslech Zadalla , Milewicz Andrzej , Panidis Dimitrios

Objective: Polycystic ovary syndrome (PCOS) is hypothesized to originate in foetal life, while its long-term consequences extend beyond menopause. However, the natural course of the disorder has not as yet been elucidated, and recent data suggest differences in the evolution of PCOS according to a woman’s weight. We aimed to define the evolution of normal-weight Caucasian women with PCOS through the years.Design: Cross-sectional case control study</...

ea0070aep821 | Reproductive and Developmental Endocrinology | ECE2020

Prevalence and prognostic factors of dysglycemia in women with polycystic ovary syndrome: Findings from large caucasian cohort

Livadas Sarantis , Bothou Christina , Kuliczkowska-Płaksej Justyna , Robeva Ralitsa , Vryonidou Andromahi , Bjekic Macut Jelica , Androulakis Ioannis , Mouslech Zadalla , Milewicz Andrej , Panidis Dimitrios , Macut Djuro

Background: Insulin secretory defects and insulin resistance exists in women with polycystic ovary syndrome (PCOS) and are prerequisites for the development of type 2 diabetes (T2D). we aimed to determine the prevalence of T2D, impaired glucose tolerance (IGT) and impaired fasting glucose (IFG), as well as the factors associated with these dysglycemic conditions in this population.Methods: 1614 PCOS women of Caucasian origin (Rotterdam criteria) with a m...

ea0070ep470 | Thyroid | ECE2020

Thyroid Dysfunction in patients with HIV infection

Kalogeris Nikolaos , Herolidi Eleni , Moustaki Melpomeni , Dermetzoglou Alexandros , Loi Vasilikh , Vakali Eleni , Lioni Athina , Sakka Vissaria , Mangafas Nikolaos , Chini Maria , Vryonidou Andromahi

Background: The incidence of endocrine complications among patients with HIV infection has decreased over the last years owing to widespread administration of combined Antiretroviral Therapy (cART) at early stages of the disease. We conducted a prospective observational study aiming to characterize the effects of cART on thyroid function in a cohort of newly diagnosed treatment-naive male patients.Materials and methods: Male subjects diagnosed with HIV i...