Endocrine Abstracts

Determination of radiochemical purity (RCP) of radiopharmaceuticals based on 68Ga-BCA-peptides (68Ga-DOTA-TOC/-TATE, 68Ga-NODAGA-RGD2, 68Ga-PSMA-HBED-CC, etc.) is an extremely important part of QC in routine clinical practice. Nature of gallium leads to formation of two major radiochemical impurities in the radiopharmaceutical: hydrolyzed 68Ga (colloid) and unbounded ionic forms of 68Ga. The amounts o...

Several recent studies have shown that early intensive insulin therapy can improve β-cell function in newly diagnosed type 2 diabetes. However, in clinical practice, insulin therapy has not been widely used in out-patients due to the fact that insulin therapy is perceived by the patients as the strongest and the last remedy and patients fear that, once on that therapy, they will have to remain on it for life. In fact, based on our clinical data, out-patients, who were new...

Material and methods: Data for 124 554 DM patients is contained in the DM register of Moscow region (MR) for 2004. Mortality is evaluated yearly.Results: Mortality as result of T1D was 1.92, and of T2D – 41.82 people for 100 thousand population. Mortality among men surpasses mortality among women for T1D (2.11 men/1.76 women), whereas the opposite was observed for T2D (58.79 women/21.81 men). Life expectancy after a diagnosis of sugar diabetes is ma...

Introduction: Educating patients about diabetes plays a pivotal role in encouraging people to changing lifestyle and supporting them to improve the quality of life, and actively responsibile for self control of their condition.Objective: To evaluate self management after receiving diabetes education for newly diagnosed Type 2 diabetes in Mongolia.Methods: The cross-sectional survey was conducted from May and October 2011. At Diabet...

Background: Despite its desirable half-life and high-energy Auger electrons, 67Ga has been neglected as a therapeutic Auger electron emitter, due in part to lack of suitable chelators and targeting molecules.Objective: Here, 67Ga is compared with Auger electron emitter 111In as a therapeutic radionuclide in prostate cancer and breast cancer cell lines.Method: Plasmid pBR322 studies allowed direct co...

Objective: We longitudinally assessed the overall and age- and sex-specific incidence rates and relative risks of newly diagnosed diabetes mellitus in patients surviving the first-attack acute pancreatitis (AP) as compared to matched controls.Methods: Study cohort included 2966 AP patients and 11 864 non-AP controls individually matched on age, sex and date of index admission, with an AP/non-AP ratio of 1:4. Incidence rate was estimated under Poisson ass...

Objective: To study relationship between osteoprotegerin (OPG) and bone metabolism markers in postmenopausal women with primary hyperparathyroidism (PHPT) compared postmenopausal women without PHPT.Materials and methods: We studied 30 postmenopausal women with PHPT, average age 62.5±6.12. The control group were 16 postmenopausal women without PHPT, mean age 59.7±6.28 in physiological menopause. ...

Introduction: In primary hypothyroidism, the increase in TRH may cause hyperplasia in the pituitary gland. It has been reported that long-standing hypothyroidism might also cause irreversible pituitary damage, which may lead to a deficiency in one or more pituitary hormones. Herein, we report a case with primary autoimmune hypothyroidism causing pituitary enlargement mimicking pituitary macroadenoma and secondary adrenal insufficiency. Case: A 17-year-ol...

Introduction: Giant prolactinomas are rare tumors accounting for 2–16% of all prolactinomas. They may be aggressive and invasive. Rarely, they might not have a suprasellar component and grow downward. Such extension can make it difficult to distinguish pituitary adenoma from other skull base tumors. We present a case that was considered to be chordoma based on clinical and radiological imaging features, but was diagnosed as prolactinoma by pituitary biopsy.<p class="a...

Introduction: Coronavirus disease-19 (COVID-19) pandemic renders high morbidity and mortality. Glucocorticoid excess is characterized by increased susceptibility to infections due to impairment of the innate and adaptive immune system. Manifestations of Cushing disease (CD) including diabetes mellitus (DM), hypertension, and obesity are risk factors for severe COVID-19 disease. We present three CD patients with different clinical courses of COVID-19. The patients’ general...