Endocrine Abstracts

IntroductionThe prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) varies according to age, gender and nationality. In the general population, the incidence is about 15–25%. Liver disease increases with age and its prevalence is higher in menopausal women suggesting that steroid sex hormone metabolism may play a role in the pathogenesis of NAFLD.AimThe purpose of this systematic review was to invest...

Thyrotoxicosis (T) develops as a result of persistent excess of thyroid hormones (TH). There are two groups of diseases that are fundamentally different in pathogenesis. The first group includes those in which the production of TH increases. Diseases of the second group are accompanied by T caused by destruction of the thyroid gland tissue. Therapeutic approaches for different types of T are different, therefore, a careful differential diagnosis of T is necessary, even if at f...

Background: The menopausal transition has been associated with a heightened risk of cardiometabolic complications, including new onset diabetes mellitus (NODM). Statin-use increases the NODM-risk in the general population, however, their impact on NODM-risk specifically in postmenopausal populations has not been adequately studied.Objectives: To estimate the effect of statin-use at baseline on the risk of NODM in postmenopausal women.<p class="abstex...

Introduction: The 22q11.2 deletion syndrome (22q11.2DS) caused by a microdeletion of the 22q11.2 region of chromosome 22 is the most common deletion in humans causing a variety of disorders, including DiGeorge syndrome (OMIM #188400), velocardiofacial syndrome (OMIM #192430) and distal chromosome 22q11.2 deletion syndrome (OMIM #611867). Most individuals diagnosed with this condition are identified in early childhood and the diagnosis in adults is uncommon. It is characterized...

Taking into account heterogeneity of somatotrophic tumors (STs), intragroup differential diagnostics is of practical importance, since it allows to predict scenario of acromegaly clinical course, as well as the efficacy of secondary drug therapy (DT).The aim of this study was to determine prognostic power of cytological, immunological&radiological predictors of sensitivity/resistance to fg-SRLs in patients with pure somatotropinomas.Materials and Met...

Introduction: Transsphenoidal surgery is the gold standard of treatment for most masses of the hypothalamic-pituitary region. Given the frequency of its performance in large hospitals, water-electrolyte complications are quite common and are the second most common cause of re-hospitalization of patients. Water-electrolyte disorders after transnasal adenomectomy in up to 30% of cases are associated with the development of severe neurological symptoms, decrease in the quality of...

Introduction: Acromegaly can be asymptomatic for a long time and morbid obesity can mask typical clinical signs (facial disfigurement, large hands and feet) and even severe disorders, such as hypopituitarism, cardiomyopathy, respiratory dysfunction, sleep apnea, atherosclerosis, endothelial dysfunction, arthropathy, prediabetes/diabetes, dyslipidemia and mineral dysmetabolism. Menstrual irregularity and infertility combined with headaches are among the earliest issues a patien...

Introduction: Statistical data show that in the etiological structure of ACTH-ectopic syndrome pheochromocytoma occupies one of the last places in terms of frequency of occurrence (from 2.8 to 5.6%) Its manifestations such as adrenal mass with ACTH-dependent hypercortisolism lead to significant difficulties in establishing the correct diagnosis.Clinical Case: A patient with clinical manifestations of hypercortisolism underwent laboratory testing in Octob...