Searchable abstracts of presentations at key conferences in endocrinology

ea0026p694 | Diabetes complications | ECE2011

Type 2 diabetes mellitus and testosterone: a meta-analysis study

Corona Giovanni , Monami Matteo , Rastrelli Giulia , Aversa Antonio , Lenzi Andrea , Forti Gianni , Mannucci Edordo , Maggi Mario

Introduction: Type 2 diabetes mellitus (T2DM) is often associated with male hypogonadism. The role of testosterone replacement therapy (TRT) in T2DM has not been completely clarified. To systematically analyse the relationship between androgen levels and T2DM by reviewing and meta-analyzing available prospective and cross-sectional studies. In addition, a specific meta-analysis on the metabolic effects of TRT in available randomised clinical trials (RCTs) was also performed.</...

ea0016p616 | Reproduction | ECE2008

Estimated cardiovascular risk and arteriogenic erectile dysfunction

Corona Giovanni , Mannucci Edoardo , Fisher Alessandra , Lotti Francesco , Balercia Giancarlo , Petrone Luisa , Forti Gianni , Maggi Mario

Objectives: Recommending general dynamic penile color doppler ultrasound (D-PCDU) screening in patients with erectile dysfunction (ED) has been questioned due to an inadequate cost-benefit ratio. The aim of the present study is to asses the validity of different risk scores in the identification of patients being screened for arteriogenic ED at D-PCDU.Design and methods: A consecutive series of 738 (mean age 53.6±9.2 years) patients with ED was stud...

ea0014p193 | (1) | ECE2007

The metabolic syndrome and associated sexual dysfunction: psychobiological correlates

Corona Giovanni , Mannucci Edoardo , Petrone Luisa , Mansani Riccardo , Balercia Giancarlo , Chairini Valerio , Forti Gianni , Maggi Mario

Objectives: The aim of present study is to determine psychobiological characteristics of sexual dysfunction (SD) associated with metabolic syndrome (MS; as defined by National Cholesterol Education Program’s Adult Treatment Panel III, NCEP-ATP-III criteria) in a consecutive series of 803 male out-patients.Methods: Several hormonal, biochemical and instrumental (penile doppler ultrasound, PDU) parameters were studied, along with psycho...

ea0081ep913 | Reproductive and Developmental Endocrinology | ECE2022

Color-doppler ultrasound predicts hypothalamic-pituitary-testicular axis function in infertile patients

Grande Giuseppe , Palego Pierfrancesco , Canossa Andrea , Caretta Nicola , Nisio Andrea Di , Corona Giovanni , Ferlin Alberto , Foresta Carlo , Garolla Andrea

Scrotal color-doppler ultrasonography (sCDUS) and transrectal ultrasonography (trCDUS) provide crucial information about the clinical status of testes and male accessory glands. However, the US evaluation of the infertile male is still often considered as a second level diagnostic tool. To analyze the role of ultrasound in male infertility, in order to predict hypothalamic-pituitary-testicular axis function, 1120 records from infertile men were retrospectively evaluated (from ...

ea0035p692 | Male reproduction | ECE2014

Clinical implications of measuring prolactin levels in males of infertile couples

Lotti Francesco , Corona Giovanni , Maseroli Elisa , Rossi Matteo , Silverii Antonio , Degl'Innocenti Selene , Rastrelli Giulia , Forti Gianni , Maggi Mario

Introduction: Although in females of infertile couples abnormal PRL has a definitive role in the medical flow-chart, its role in males is less clear. Animal models suggest that PRL does not play a major role in male reproduction, although its trophic action on male accessory glands was often observed. Studies in humans are scanty. We systematically evaluated possible clinical and ultrasound correlates of PRL in males of infertile couples.Methods: Out of ...

ea0035p694 | Male reproduction | ECE2014

Seminal, clinical and color-Doppler ultrasound correlations of prostatitis-like symptoms in males of infertile couples

Lotti Francesco , Corona Giovanni , Mondaini Nicola , Maseroli Elisa , Rossi Matteo , Filimberti Erminio , Noci Ivo , Forti Gianni , Maggi Mario

Introduction: ‘Prostatitis-like symptoms’ (PLS) are a cluster of bothersome conditions defined as ‘perineal and/or ejaculatory pain or discomfort and National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) pain subdomain score ≥4’ (Nickel’s criteria). PLS may originate from the prostate or from other portions of the male genital tract. Although PLS could be associated with ‘prostatitis’, they should not be confused. T...

ea0035p955 | Steroid metabolism and action | ECE2014

Testosterone supplementation and sexual function: a meta-analysis study

Corona Giovanni , Isidori Andrea M , Buvat Jaques , Aversa Antonio , Ratrelli Giulia , Hackett Geoff , Rochira Vincenzo , Lenzi Andrea , Maggi Mario

Introduction: The role of testosterone supplementation (TS) as a possible treatment for male sexual dysfunction remains questionable. The aim of the present study is to meta-analyse data evaluating the effects of TS on male sexual function and its therapeutic synergism with the use of phosphodiesterase type 5 (PDE5i).Methods: An extensive Medline Embase and Cochrane search was performed including the following words: ‘testosterone’, ‘erect...

ea0032p642 | Male reproduction | ECE2013

Seminal, ultrasound and psychobiological parameters correlate with metabolic syndrome in male members of infertile couples

Lotti Francesco , Corona Giovanni , Innocenti Selene Degli , Filimberti Erminio , Scognamiglio Vittoria , Vignozzi Linda , Forti Gianni , Maggi Mario

Introduction: Metabolic syndrome (MetS) is a diagnostic category which identifies subjects at high risk for diabetes and cardiovascular diseases, erectile dysfunction (ED) and male hypogonadism. However, MetS impact on male infertility has been poorly studied. We systematically evaluated possible associations between MetS and clinical characteristics in men with couple infertility.Methods: Out of 367 consecutive subjects, 351 men without genetic abnormal...

ea0032p675 | Male reproduction | ECE2013

Investigation on psychological symptoms improves ANDROTEST accuracy in predicting hypogonadism in subjects with sexual dysfunction

Rastrelli Giulia , Corona Giovanni , Bandini Elisa , Strada Carolina , Maseroli Elisa , Ricca Valdo , Faravelli Carlo , Mannucci Edoardo , Maggi Mario

The role of psychological symptoms in recognizing late-onset hypogonadism (LOH) is still controversial. The aim of the study is to evaluate the association between LOH and specific psychological symptoms and to verify whether investigating intra-psychic domain improves the accuracy of a validated case-history tool (ANDROTEST) in detecting LOH. A consecutive series of 1009 subjects (mean age 49.23±13.34) consulting for sexual dysfunction was studied. Intra-psychic symptoms...

ea0032p758 | Obesity | ECE2013

Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a meta-analytic study

Corona Giovanni , Rastrelli Giulia , Monami Matteo , Saad Farid , Luconi Michaela , Lucchese Marcello , Sforza Alessandra , Forti Gianni , Mannucci Edoardo , Maggi Mario

Introduction: Few randomised clinical studies have evaluated the impact of diet and physical activity on testosterone levels in obese men with conflicting results. Conversely, studies on bariatric surgery in men generally showed an increase in testosterone levels. The aim of the present study is to perform a systematic review and meta-analysis of available trials on the effect of body weight loss on sex hormones levels.Methods: An extensive Medline searc...