Endocrine Abstracts

Introduction: the presence of areas with a solid / trabecular growth pattern in differentiated papillary thyroid carcinoma (PTC) represents a source of controversy regarding clinical and prognostic significance and usually requires a more aggressive therapeutic approach. The aim of this study was to compare clinicopathological characteristics, treatments and prognosis of PTC with and without solid component (SC). We also aimed to evaluate whether SC affects patient outcome in ...

Objectives: The clinical significance of antithyroglobulin antibody (TgAb) levels verified concomitantly with undetectable thyroglobulin (Tg) during the follow-up of patients with differentiated thyroid carcinoma remains under debate. The present study aimed to evaluate the presence and prognostic predictive value of TgAb during the follow-up of patients with differentiated thyroid carcinoma.Methods: A retrospective cohort study was performed by reviewin...

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease ranging from intrahepatic lipid accumulation to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Liver 5β-reductase (AKR1D1) catalyses a fundamental step in bile acid (BA) synthesis. BAs and BA intermediates are potent regulators of metabolic and proliferative phenotype. We have hypothesised that AKR1D1 plays a crucial role in NAFLD and HCC. Liver biopsies and serum samples were obtained from healt...

Introduction: Wernicke’s encephalopathy, resulting from thiamine deficiency, is a rare but serious neurological complication of bariatric procedures. The diagnosis is still difficult since the classic clinical triad (confusion, ataxia and oculomotor abnormalities) and the typical radiological features (areas of hyperintensity in mammillary bodies, thalamus, periaqueductal and periventricular gray matter) are not always present. Also, thiamine blood tests are not broadly a...

Introduction: Hypocalcaemia is a rare and potentially reversible cause of cardiomyopathy. Restoration to normal serum calcium levels usually leads to rapid improvement of cardiac function.Case report: A 42-year-old woman with a history of total thyroidectomy, due to large nodular goiter in 2016, and acute pos-operative hypoparathyroidism, assumed to be transient, with no supplementation since early 2017. In September 2018 she was admitted due to acute ca...

Introduction: The somatotropin deficit is one of the late consequences of cancer treatments. The administration of somatotropin implies treatment with daily injections, which hinders therapeutic adherence. This goal is a challenge for survivors and health professionals. Therapeutic education and new technologies are instruments that favor the training and development of control mechanisms that promote and motivate the behavior’s change.Objective: To...

Introduction: Adrenal gland involvement can be seen in about 25% of lymphomas. However, primary adrenal lymphomas (PAL) are rare. The most common is diffuse large B-cell lymphoma (DLBCL). It is seen usually after the age of 60 years as bilateral, large masses.Case report: A 64-year-old woman with a complaint of abdominal pain was referred to our clinic after bilateral surrenal masses were detected upon abdominal ultrasonography (USG) and computed tomogra...

Although primary hyperparathyroidism (PHPT) is usually cured by surgery, some individuals are unable to undergo parathyroidectomy and are refractory to standard calcium lowering medical therapy. In such cases, targeted therapy with cinacalcet may be useful.The aim of this study was to access the short-term efficacy of cinacalcet in lowering calcium (Ca2+) levels in patients with PHPT unable to undergo parathyroidectomy and refractory to standa...

Introduction: Asparaginase is a component of chemotherapy regimens used to treat paediatric acute lymphoblastic leukaemia (ALL). One of its well-known side effects is hyperglycaemia which is probably related to hypoinsulinemia. Its incidence rises significantly when associated with corticotherapy. We present two cases of diabetes related to asparaginase and corticoid administration.Case 1: Eleven-year-old girl diagnosed with an ALL. Before treatment she ...

Introduction: Clinically nonfunctioning pituitary adenomas (NFPA) are the most common pituitary tumor type. They are usually recognized after they cause symptoms especially when tumor size increases and eventually invades adjacent structures. Nevertheless the discovery would also be accidental. In the literature some kind of gender difference is reported in NFA’s behavioral results such as pituitary axis deficits or consequences of surgery however they resulted with contr...