Endocrine Abstracts

Introduction: A rare cause of hypoglycemia is non-islet cell tumor hypoglycemia (NICTH), a paraneoplastic syndrome caused by tumoral overexpression of insulin-like growth factor 2 (IGF-2) and pro-IGF-2.Case presentation: : A 57-year old woman presented with odd behavior each morning that improved after breakfast and extensive weight loss (13 kg in 3 years). The patient was hypoglycemic (2.6 mmol/l) with low insulin levels (<1.39 pmol/l) and C-peptide...

Introduction: Aggressive pituitary tumours are rare (<2% of pituitary macroadenomas) and are characterized by local invasiveness, progressive growth, and multiple recurrences despite conventional treatments. Approximately 30-40% of these tumours are functioning corticotroph adenomas. Diagnosis relies on clinical, imaging evaluation with magnetic resonance imaging (MRI), hormonal, and pathological assessments. Its therapeutic approach is challenging.C...

Introduction: KS prevalence is estimated to range from 0.1-0.2 % in men and actually the estimated frequency is of about 1:500 to 1:1000 men1. However, the real prevalence remains unknown due also to the fact that the disease is often overlooked and undermanaged1.Aim and methods: We performed a systematic literature search including studies published between 1971 and January 2024 to investigate the real prenatal prevalence of KS (in...

Background and aims: Low levels of testosterone and non-alcoholic fatty liver disease (NAFLD) in obese men are both linked to the metabolic syndrome, but the independent association between testosterone and NAFLD needs to be elucidated. In this cross-sectional analysis the association between total testosterone (total T) and calculated free testosterone (cFT) on the one hand and NAFLD, non-alcoholic steatohepatitis (NASH) and fibrosis on the other hand was investigated in obes...

Background: Primary hyperaldosteronism (PA) is a prevalent, but underreported syndrome. Diagnostic procedures and treatment options have been relatively constant since the development of the latest guideline of the Endocrine Society in 2016.Study objective: To clinically and biochemically describe subjects with PA who underwent a salt infusion test (SIT) or an adrenal venous sampling (AVS) in a tertiary hospital since 2009 and provide an overview of thei...

Obesity is associated with peripheral and central low grade inflammation characterized by the increase in pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF). Phosphodiesterase 4 (PDE4) modulates the inflammatory responses and its inhibitor can strongly reduce TNF release and inflammation. Additionally, PDE4 knockout mice were shown to be resistant to diet-induced obesity (DIO). The aim of this study was to investigate the role of central and peripheral effec...

Background: A common request at an endocrine outpatient clinic is to rule out acromegaly in a patient with acromegaloid features. It is important to do so, since the excessive excretion of growth hormone can result in various serious comorbidities. But when growth hormone-IGF-1 axis abnormalities are excluded, the physician faces a diagnostic dilemma. Here we provide a systematic approach to these patients.Methods: We present a case series of patients vi...

Background: Adrenal insufficiency is a rare but potentially life threatening complication of the antiphospholipid antibody syndrome (APS). The adrenal gland is the most commonly involved endocrine organ with adrenal insufficiency reported in 0.4% of APS cases. Adrenal failure more often follows other thromboembolic manifestations of APS.Case report: We report a 25-year-old male with systemic lupus erythematosus (SLE) with antiphospholipid syndrome (tripl...

Background and aims: In adipose tissue, excess of energy is stored inside cytosolic lipid droplets as triglycerides. During fasting or exercise, the stored fat is mobilized for utilization as free fatty acids and glycerol via lipolysis. The complete lipolysis of triglycerides is mediated by the orchestrated activation of adipose triglyceride lipase (ATGL) and hormone-sensitive lipase, which have been associated with obesity. There is compelling evidence that the protein compar...

Introduction: The cause of primary hyperparathyroidism (PHPT) is a single adenoma in 85% of cases. Scintigraphy with technetium-sestamibi (MIBI) is the test of choice for localising adenomas in patients with PHPT, allowing minimally invasive surgery in most patients. Some articles recommend thyroid function supression to improve scintigraphy results.Methods: A prospective study was conducted in which 8 patients were included with diagnosis of PHPT and ne...