Endocrine Abstracts

Dehydroepiandrosterone is the most abundant steroid hormone circulating in the human body, we focused on its 7-hydroxylated derivatives. Many observations in rodents have demonstrated the anti-inflammatory and immune modulating activity of 7β-hydroxy-androst-5-enes, and on the basis of these experiments androst-5-ene-3β,7β,17β-triol is considered as a potential agent in the treatment of autoimmune diseases. In contrast to the fairly abundant information on ...

Introduction: Subclinical Cushing’s syndrome (SCS) occurs in up to 12% of patients with incidentally found adrenal masses. Optimal management remains controversial. We report our experience of nine patients with SCS managed at our institution from 2007 to 2016.Methods: All patients were referred for adrenal incidentalomas (AI) and had no discriminatory clinical features of Cushing’s syndrome. SCS was defined using cortisol levels > 138 nmol...

Background: Many studies indicated an increased cancer incidence and cancer mortality in subjects with diabetes mellitus. But most of studies have been surveyed in western countries and have problems in applying the results to Korean. We aimed to evaluate the site specific cancer risk of diabetic patients in Korea over 30 years, and investigate causal relationship and temporal relationship by analyzing the organ-specific cancer risk in diabetics according to duration.<p cl...

Abstract: Dihydrotestosterone (DHT) is the most powerful naturally occurring androgen with three to six times higher biopotency than testosterone. Time onset of benign prostatic hyperplasia and alopecia in middle life could be the result of an imbalance between androgens. The decline of testosterone during lifespan is well known, controversial data can be found concerning the age dependence of DHT levels. We analysed the levels of testosterone, dihydrotestosterone and SHBG fro...

Introduction: Obesity increases the incidence of hypogonadism in men, and hypogonadism in turn plays a role in obesity. One of the first mechanisms proposed to explain this was a hypothesis based on the principle that obese men have higher estrogen levels, and that increased estrogens provide feedback to the hypothalamic-pituitary-testicular axis, reducing the secretion of gonadotropins and leading to a decrease of overall testosterone levels. This concept has since been quest...

Introduction: Neuroendocrine tumours (NETs) of unknown primary site are relatively uncommon, representing about 10% of all NETs. Of these, particularly the well-differentiated NETs often present initially with liver metastases, and most of these represent gastroenteropancreatic NETs. The presence of carcinoid syndrome is also common.Case presentation: We describe the case of a 40 years-old patient presented in 2013 with flushing, diarrhea, and back pain....

Context: Postoperative central diabetes insipidus (PDI) is one of the most common complications of surgical treatment of pituitary adenoma, temporary or permanant. The diagnosis of PDI was suspicious in some occasions and inappropriate prescription of antidiuretic hormone was harmful. Generally, high level serum uric acid (HUA) was a clue for central diabetes insipidus, but we did not know its role for the brain postoperative subjects. As we know, the food intake and health co...

Objectives: To investigate how CO-GHD patients are taken care of in paediatrics, during the transition period and in long-term adult follow-up.Methods: Retrospective cohort study of CO-GHD patients, transferred in our adult department between 1994 and 2011. Paediatric charts were available for all patients. For adult follow-up, parameters of metabolic, bone and cardiovascular status were recorded at several hospitalisations: the first one (V0) and at 1 (...

Introduction: Excessive iodine intake can cause iodine overnutrition, goiter and other thyroid disease. This study is to probe the determinants of children’s iodine nutrition and their goitrous and nodular prevalence in areas with excessive iodine in drinking water in Hebei province of China. Methods Three townships were selected by simple random sampling among the 8 townships with median water iodine being 200–300 μg/l in Hengshui prefecture of Hebei province. ...

IntroductionAdjuvant endocrine therapy has an important role in the management of hormone receptor-positive (expressing oestrogen/progesterone receptors) early-stage breast cancer, reducing the risk of recurrence and improving associated mortality. The estradiol depletion produced by hormone therapy has detrimental effects on skeletal health, which can lead to low bone mineral density (BMD), altered bone microarchitecture and increased risk of fracture.<...