Endocrine Abstracts

First generation somatostatin receptor ligands (SRL) are the first-line drugs in primary acromegaly treatment or after surgical failure in patients with active acromegaly. In previous studies we confirmed the association of the expression of SSTR2, Ki67 and E-cadherin (CDH1) in responsive GH-secreting adenomas response to SRL. Moreover, E-cadherin showed a greater predictive capacity than most of the markers described. Loss of E-cadherin is a typical mark of ...

Objective: To study the association between the state of iodine nutrition, and the risk of total and cause mortality in a representative sample of the Spanish adult population.Design: Longitudinal observational study to estimate mortality risk according to urinary iodine (UI) concentrations using a sample of 4370 subjects >18 years representative of the Spanish adult population participating in the national study [email protected] (2008–2010). We used ...

Introduction: Trabecular Bone Score (TBS) is a new non-invasive method to evaluate trabecular bone quality at the lumbar spine. The literature has contradictory results concerning the influence of insulin resistance and adipose tissue on bone, for this reason it is of interest to evaluate factors that determine bone health and risk of fracture in patients with T2DM.Objective: To analyze the relationship between insulin resistance and adipose tissue with ...

Introduction: Ectopic Cushing Syndrome (ECS) is a rare disease associated with significant comorbidity. Among the causes of Cushing’s syndrome (CS), ACTH-producing extrahypophyseal tumours are rarely reported. The aim of our study is to describe the clinical, diagnostic and therapeutic characteristics of patients with ECS treated in our Endocrinology department over a 15-year period.Methods: A cross-sectional unicentric retrospective study was desi...

Objectives: To describe the results of the bilateral inferior petrosal sinus sampling (BIPSS) performed in our hospital for differential diagnosis between Cushing disease (CD) and ectopic ACTH secretion (EAS), and evaluate if CRH stimulation during this test improves its diagnostic accuracy.Material and Methods: We retrospectively review 29 BIPSS performed in 26 patients (4 men, 22 women), with mean age of 44.7 year-old (range 28–69), diagnosed wit...

Introduction: Acromegaly is an insidious disease caused by chronic GH and IGF-I hypersecretion associated with increased morbidity and mortality, mostly from cardiovascular complications. The aim of this study is to compare cardiovascular risk factors, between patients with medical treatment vs cured.Materials and methods: This is a retrospective study of 37 acromegalic patients, 21 well controlled with medical treatment (IGF-I within the normal range fo...

Women with positive thyroid autoimmunity are considered at risk of developing hypothyroidism in pregnancy, so monitoring thyroid function is recommended.Objective: To assess the risk of gestational hypothyroidism in pregnant women with autoimmune thyroid disease and normal thyrotropin (TSH) at the beginning of pregnancy.Methods: Retrospective review of data from pregnant women attended between April 2016 and October 2019. Women wit...

Objective: To evaluate the monitoritation systems acceptance: capillary glucose measurements and continuous glucose sensors (CGSM and GUARDIAN).Research design and methods: 15 diabetics patients were monitoritatied in two diferents periods of time. (Period 1: Guardian, 86 hours long. Period 2: CGSM 72 hours long). Later, they had to fill a satisfaction questionnaire concerning several aspects which were valued from 0–6.<table boarder="1" cellpad...

Introduction: Pheocrhomocytomas are rare tumors, principally benigns, and with high risk of morbimortality because of secretion of big amountos of catecholamines. They are an unfrequently cause of arterial hypertension in pediatric age but physicians must remember it because they can be diagnosed, treated and cured in a proper way.Objectives: To evalue the cases reports of pediatric pheochromocytoma found in our area, to analyze the differences in diagno...

Introduction: Graves disease (GD) is inherited as a complex multigenic disorder. One of the most promising genes for susceptibility to GD is cytotoxic T lymphocyte antigen-4 (CTLA4), a negative regulator of T-cell activation.Objective: The aim of this study was to determine whether A/G polymorphism in exon 1 of the CTLA-4 gen was associated with GD in spanish patients.Patients and methods: Fifty one adult GD patients and 25 unrelat...