Endocrine Abstracts

Thyroid papillary carcinoma (PTC) is the most common endocrine tumor, Hashimoto’s thyroiditis (HT) is considered to be closely related to PTC pathogenesis, but their relationship still needs verification and exploration. Aim of the study. To analyze the differences and similarities of the metabolic mechanism of thyroid papillary carcinoma in normal and HT background, and to explore the relationship between HT and PTC. The Ultra performance liquid chromatography-q...

Obesity, as a chronic nutritional disorder, is a high-risk factor for type 2 diabetes, fatty liver and other metabolic diseases. Multiple lncRNAs have been confirmed concerning adipocyte differentiation and thus affect obesity, such as ADINR, Paral1, etc. Previously, we identified a lncRNA named ENST0000052114 (abbreviated to lncRNA52114), highly expressed in human mature adipocytes by differential lncRNA expression profile. Here, we explored the role and mechanism of lncRNA52...

Objective: Non-alcoholic fatty liver disease (NAFLD) is considered as a continuum from obesity and metabolic syndrome (MetS). To investigate the cardiovascular prognosis of metabolically healthy NAFLD, this study aimed to evaluate the association between NAFLD with and without MetS and change in coronary artery calcification (CAC).Methods: This is a retrospective longitudinal study of 5,117 subjects without cardiovascular disease who participated in a he...

The primary cilium, a non-motile microtubule-based organelle protruding from most vertebrate cells, serves as a specialized compartment for signal transduction. Any disruption of ciliogenesis leads to ciliopathy-spectrum disorder with multiple signalling failure in development and homeostasis. Several ciliopathies including Bardet–Biedl syndrome associate with infertility and hormone imbalances, but the role of primary cilia in reproductive disorders is not clear. Congeni...

Objective: Randomized trials demonstrated a lower risk of cardiovascular (CV) events with sodium – glucose cotransporter-2 inhibitors (SGLT-2i) in patients with type 2 diabetes(T2D) at high CV risk. SGLT2-i should be considered as a valuable therapy in T2D with established atherosclerotic cardiovascular disease (ASCVD) or heart failure (HF). We analyzed the effects of cardiovascular function of SGLT 2 inhibitors in T2D with ASCVD or HF compared with dipeptidyl peptidase-4...

Background: The prevalence of type 2 diabetes mellitus is very high among elderly people and can faster the cognitive decline and the loss of independence, if not treated adequately. Another topic not clearly explained yet is the relationship between vitamin D and type 2 diabetes mellitus.Objective: The aim of our work is to reveal relationship between diabetes control and self-sufficiency and to determine the possible impact of the current levels of vit...

Octreotide is first-line medical therapy for patients with acromegaly. Up to 80% of patients are not satisfactorily controlled on octreotide alone and up to 20% have no response. COR-005 (previously DG3173) is a novel somatostatin analogue under investigation for treatment of acromegaly. COR-005 has high affinity for human somatostatin receptor subtypes 2, 4 and 5.The study was designed to assess pharmacokinetics of escalating doses COR-005 sc tid and co...

Obesity caused by excess energy intake has been emerging as a major health concern in the world, with increased risk leading to diabetes, hypertension, nephropathy, and cardiovascular disease. A better understanding of the molecular mechanism on how obesity develops is of critically clinical importance. Accumulating data suggest that ER-stress is strongly related with development of obesity, implying that ER stress can be a therapeutically target of obesity. 4-Phenylbutyrate (...

Objectives: Various systemic symptoms may occur in patients with thyrotoxicosis. Gastrointestinal manifestations such as hyperphagia or frequent defecation, often coexist with other thyrotoxic symptoms. Vomiting also has been mentioned.In this setting, systemic symptoms of underlying malignancy may be confused with those of thyrotoxicosis leading to a delay in diagnosis.Methods: We report a case with delayed diagnosis of small bowe...

Objective: This study was performed to determine the impact on quality of life and sleep impairment of painful diabetic peripheral neuropathy (PDPN).Research design and method: The study pool consisted of 200 randomly selected peoples with type 2 diabetic peripheral neuropathy. PDPN was diagnosed using visual analogue scales (VAS) and medical history. The patients were asked to answer the Brief Pain Inventory-Short Form (BPI-SF), Medical Outcomes Study S...