Searchable abstracts of presentations at key conferences in endocrinology

ea0095oc10.1 | Oral Communications 10 | BSPED2023

The real-world experience of long acting growth hormone in children with growth hormone deficiency

Ramya Gokul Pon , Jarvis Charlotte , Laing Peter , Das Urmi , Ramakrishnan Renuka , Dharmaraj Poonam , Blair Jo , Didi Mohammed , Senniappan Senthil

Introduction: Long-acting growth hormone (LaGH) therapy has emerged as a newer treatment option for children, with the potential to improve adherence and compliance. Clinical trials have shown LaGH formulations to be effective and safe in children with GH deficiency (GHD). Somatrogon (Ngenla) is licensed for use in children with GHD over than 3 years of age.Objective: We report the real-world experience of using once wee...

ea0081oc13.3 | Oral Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

11-oxygenated C19 steroids are the predominant androgens responsible for hyperandrogenemia in Cushing’s disease

Nowotny Hanna , Vogel Frederick , Bidlingmaier Martin , Braun Leah , Reincke Martin , Tschaidse Lea , Auer Matthias , Lottspeich Christian , Hawley James M , Adaway Jo , Keevil Brian , Schilbach Katharina , Reisch Nicole

Background: Symptoms of hyperandrogenism are common in patients with CushingÂ’s disease (CD), but they cannot be sufficiently explained by measured concentrations of circulating androgens. In this study we analyzed the contribution of 11-oxygenated (11o×C19) androgens to hyperandrogenemia in female patients with CD as well as the influence of treatment with steroidogenesis inhibitors osilodrostat and metyrapone on 11o×C19 and classic androgens.<p class="abste...

ea0081oc13.4 | Oral Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Classic and 11-oxygenated androgens in serum and saliva across adulthood and the menstrual cycle – a mass spectrometry-based cross-sectional study

Kempegowda Punith , Schiffer Lina , Adaway Jo , Shaheen Fozia , Ebbehoj Andreas , Singh Sumitabh , Prete Alessandro , Hawley James M , Sitch Alice J , Keevil Brian , Bancos Irina , Taylor Angela , Arlt Wiebke

Objective: Quantify classic and 11-oxygenated androgens in serum and saliva and determine variations across age, sex, body mass index (BMI), menstruation and hormonal contraception use.Methods: Morning serum samples were collected from 292 healthy volunteers (125 men, 22-95 years; 167 women, 21-91 years). Morning saliva was collected from 83 healthy volunteers (51 women, 32 men). 25 individuals (12 women, 13 men) also collected a 7-timepoint diurnal sali...

ea0063gp7 | Adrenal and Neuroendocrine - Tumour | ECE2019

Parafibromin is regulated by ubiquitin specific protease 37 (USP37) and the c-terminus of USP37 interacts with the beta-catenin binding region of CDC73 in hyperparathyroidism-jaw tumor syndrome

Kim Su Yeon , Lee Ji-young , Jo Kwan Hoon , Mo Eun Yeong , Kim Eun Sook , Han Je Ho , Baek Kwang-Hyun

CDC73 (also known as HRPT2) encodes parafibromin and is known to be the causative gene of hyperparathyroidism-jaw tumor (HPT-JT) syndrome. There is no known ubiquitination of parafibromin, and the deubiquitinating enzyme (DUB) for parafibromin has not been identified to date. Full-length DUB cDNAs encoding 58 family members of ubiquitin specific proteases (USPs) were subcloned. The DUB cDNA was used to identify parafibromin interacting by yeast two-hybrid screening. W...

ea0037ep442 | Diabetes (complications &amp; therapy) | ECE2015

Hemorheological alterations in type 2 diabetes patients with nephropathy

Lee Min Young , Jo Sehee , Kim Min Jin , Nam Ji Sun , Kang Shinae , Park Jong Suk , Ahn Chul Woo , Kim Kyung Rae

Background: Hemorheologic alterations or changes in blood viscosity have been suggested to play a role in the pathogenesis of diabetic microvascular complications. We measured various hemorheologic parameters in type 2 diabetes patients at different stages of chronic kidney disease (CKD) and assessed their possible role as early markers of diabetic nephropathy and renal insufficiency.Methods: One hundred and five patients with type 2 diabetes were divide...

ea0034p397 | Thyroid | SFEBES2014

Examination of PTTG-binding factor mRNA reveals functional miRNA target sites and exon-skipping splice variants in thyroid cells

Read Martin , Longman Jo , Fletcher Alice , Smith Vicki , Watkins Rachel , Modasia Bhavika , Poole Vikki , Imruetaicharoenchoke Waraporn , Franklyn Jayne , Boelaert Kristien , McCabe Christopher

Dysregulation of the processing and stability of mRNA encoding oncogenes or tumour suppressor proteins is a critical event in the pathogenesis of cancer. Previously, we demonstrated that the proto-oncogene PTTG-binding factor (PBF) is overexpressed in thyroid, pituitary and breast tumours. Critically, high PBF expression is associated with reduced disease-specific survival in thyroid cancer. However, the mechanisms responsible for regulating PBF expression are unknown. In this...

ea0070aep652 | Pituitary and Neuroendocrinology | ECE2020

Acrodat – a useful tool to manage acromegaly patients

Alves Helena , Almeida Ferreira Marta , Tavares Patrícia , Ramalho Diogo , Machado Catarina , Almeida Lucia , Correia Sara , João Oliveira Maria

Introduction: Acromegaly is a rare condition associated with metabolic abnormalities, risk of cardiovascular complications and increased mortality. Even when biochemical control is achieved, following surgery or medical treatment, patients still complain about disease-related symptoms.Material and Methods: Retrospective study of acromegaly patients, followed in an Endocrine outpatient clinic. Clinical and biochemical data was recorded. ACRODAT was used t...

ea0070aep795 | Reproductive and Developmental Endocrinology | ECE2020

The vulnerability of prepubertal ovarian steroidogenesis to AhR-mediated TCDD action occurs during a time-restricted window in mice

Devillers Marie , Petit Florence , Giton Frank , François Charlotte , Juricek Ludmila , Coumoul Xavier , Magre Solange , Cohen-Tannoudji Joëlle , Guigon Celine

Background: In females, timing of puberty and fertility require estradiol (E2) action at the infantile and late juvenilestages and are tightly influenced by environmental cues. A regulator of intra-ovarian E2 synthesis during reproductive life is the aryl hydrocarbon receptor (AhR). However, its action on E2 synthesis and its capacity to mediate the effect of endocrine disrupting chemicals (EDC)s has not been thoroughly evaluated during the prepubertal period.<p class="abs...

ea0070aep911 | Thyroid | ECE2020

Insulin resistance, lipid profile and low-grade inflammation in Hashimoto thyroiditis

Afonso Marta , Neves Celestino , Sérgio Neves João , Pereira Miguel , Luís Medina José , Delgado Luís , Carvalho Davide

Background: Hashimoto thyroiditis (HT) is the most common autoimmune disease and patients may present different levels of thyroid dysfunction. The association between hypothyroidism and cardiovascular events is well established. However, it remains unclear how mild thyroid dysfunction, autoimmunity and chronic inflammation in HT contribute to an increased cardiovascular risk in euthyroid patients and in subclinical hypothyrodism. Therefore, this study aims to assess insulin re...

ea0070ep499 | Thyroid | ECE2020

Endocrinopathies related to immune checkpoint inhibition: A clinical case presentation

Veríssimo David , Jácome de Castro Matilde , Ivo Catarina , Duarte Vitória , Marcelino Mafalda , Jácome de Castro João

Introduction: In the area of Immunotherapy, immunological checkpoints, such as CTLA-4, PD-1 or PD-L1, are membrane proteins involved in the immune response that, when inhibited, cause an increase in T cell activity and a consequent anti-tumor effect. However, this inhibition can also cause adverse effects, including endocrinopathies, such as thyroid dysfunction and hypophysitis.Clinical case: 59-year-old man, diagnosed with lung cancer, treated with nivo...