Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep408 | General Endocrinology | ECE2021

A new cause of endogenous hyperinsulinism?

Caballero Manuel J , José Ignacio Fernández Peña , Eyvee Arturo Cuellar Lloclla

We present the case of a patient who started having repeated episodes of symptomatic hypoglycemia at the age of 50.Medical historyFather had type 2 diabetes. Former smoker, moderate alcohol consumption. Chronic otitis media with cholesteatoma, surgically removed. Congenital cataract operated at the age of 3.Clinical courseAt around the age of 50, the patient started having sporadic epis...

ea0070aep466 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Effectiveness of PCSK9 inhibitors in familial hypercholesterolemia in asturias, spain

González Martínez Silvia , Rodriguez Escobedo Raul , Luis Fernández Morera Juan , José López Alba Alfonso , Antonio Álvarez Tamargo José , José Lamela Piteira Carlos , Villazón González Francisco

Introduction: Familial hypercholesterolemia (FH) is a genetic disorder characterized by high levels of LDL cholesterol (LDL-C) from birth. Treatment with statins and ezetimibe achieves in most cases large reductions in LDL-C. In those patients in whom the reduction in LDL-C is insufficient or who have intolerance to such treatments, the appearance of PCSK9 inhibitors has been an effective and safe alternative to achieve the LDL-C objectives.Materials and...

ea0090oc11.6 | Oral Communications 11: Late Breaking | ECE2023

Assessment of clinical and histopathological predictors for remission after transsphenoidal surgery for acromegaly

Postma Mark , Westerlaan Henriette , Willems Annet , van den Beukel Anke , Kuijlen Jos , Vergeer Rob , van der Klauw Melanie , Dunnen Wilfred den , van Beek Andre

Background: Transsphenoidal surgery (TSS) is the primary treatment of choice in acromegaly. Previous research succeeded to some extent in predicting remission after TSS. However, it was based mainly on clinical and radiological data, lacking histopathological evaluation.Objective: To produce a clinicopathological prediction model for remission after TSS for acromegaly, enabling clinicians to better inform patients on expected treatment outcome.<p cla...

ea0090p608 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Intestinimonas butyriciproducens improves glucose metabolism in subjects with obesity and prediabetes: preliminary data from a randomized controlled trial

Antoniotti Valentina , Caputo Marina , TIni Sabrina , Antonioli Alessandro , Daffara Tommaso , De Marchi Silvia , Bona Elisa , Amoruso Angela , Pane Marco , Gul Sahin , Aimaretti Gianluca , Seegers Jos , Prodam Flavia

As the prevalence of type 2 Diabetes Mellitus (T2D) is constantly increasing and the current prevention is not enough, new effective strategies are necessary, in particular in high-risk individuals. Therapeutic microbiology is one of further proposed targets, and, in particular, butyrate-producing bacteria can improve metabolic parameters in obese patients. Our study aims to evaluate the effect of Intestinimonas butyriciproducens as a preventive therapy for T2D in pre...

ea0070aep377 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

The additive effect of obesity in the incidence of neurocognitive disorders in offspring of women with gestational diabetes

Simó Andreu , Perea Veronica , Valverde Maite , Quirós Carmen , Orois Aida , García-Pascual Luis , Barahona MªJosé

Aim: Gestational diabetes (GDM) has been associated with an increased risk ofneurocognitive outcomes in offspring such as attention deficit/hyperactive disorders (ADHD) and autism spectrum disorders (ASD). However GDM-related comorbidities (obesity or excessive weight gain –EWG-) in this setting have been scarcely studied. So, the aim of our study was to estimate the risk of ADHD and ASD in this population.Material and Methods: Cohort study. Single...

ea0070aep457 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Real-life clinical experience with GLP1 analogs and SGLT2 inhibitors in the treatment of diabetes type 2 and obesity

Pérez-Rodríguez José , Calderón-Vicente Dulce , González-López Javier , Martín-Iglesias David , Alramadan Mubarak

Objectives: SGLT2 inhibitors and GLP1 analogs are the treatment of choice after metformin in patients with type 2 diabetes (DM2) and overweight-obesity (OB). The aim of this study is to analyze the effectiveness and safety of these treatments alone or in combination.Methodology: This is a retrospective observational study in the usual clinical practice. We analyzed the effects of SGLT2 inhibitors and GLP1 analogs treatments in patients with DM2 and OB wh...

ea0070aep520 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Short and long-term glycemic variability associated with severe hypoglycemia and retinopathy in type 1 diabetes mellitus

Sanz Martín Borja , Roman Gimeno Sergio , Miguel Peteiro Miranda Carlos , Jorge Ortez Toro Jose , Agudo Ana , Urdaniz Rosana , Antonio Gimeno Orna José

Introduction: Severe hypoglycemia and retinopathy are two of the main complications of diabetes mellitus (DM). Traditionally, glycosylated hemoglobin (or A1C) has been used as the gold standard measurement of glycemic control; however, there is a significant percentage of complications riskassociated with the evolution of diabetes that is not fully explained by this single marker. Short and long-term glycemic variability has been postulated as one of the main variables that co...

ea0070aep911 | Thyroid | ECE2020

Insulin resistance, lipid profile and low-grade inflammation in Hashimoto thyroiditis

Afonso Marta , Neves Celestino , Sérgio Neves João , Pereira Miguel , Luís Medina José , Delgado Luís , Carvalho Davide

Background: Hashimoto thyroiditis (HT) is the most common autoimmune disease and patients may present different levels of thyroid dysfunction. The association between hypothyroidism and cardiovascular events is well established. However, it remains unclear how mild thyroid dysfunction, autoimmunity and chronic inflammation in HT contribute to an increased cardiovascular risk in euthyroid patients and in subclinical hypothyrodism. Therefore, this study aims to assess insulin re...

ea0070aep1022 | Hot topics (including COVID-19) | ECE2020

miRNAs regulating BDNF and BDNFas in adipose tissue: Potential link between obesity and mood disorders

Lhamyani Said , Clemente Mercedes , Gentile Adriana , Chacón Pedro , Javier Pavón Francisco , José Tinahones Francisco , Olveira Gabriel , El Bekay Rajaa

Background and aim: Obesity (Ob) is tightly associated with metabolic diseases such as type 2 diabetes (DT2) andinsulin resistance (IR). Furthermore, obesity has been identified as one of the primary causes of mood disorders (MDs) including depression. Several studies have demonstrated the link between Ob, adiposity, neuroinflammation and MDs. The Brain-Derived Neurotrophic Factor (BDNF) and its regulator, the non-coding RNA BDNF antisense RNA (BDNFas), play an import...

ea0070aep1031 | Hot topics (including COVID-19) | ECE2020

Type 2 diabetics with high risk of foot amputation: Role of sodium-glucose co-transporter inhibitors

Serrano Laguna Mª del Carmen , León Utrero Sara , Hayón Ponce María , Redondo Torres Enrique , José López Ibarra Pablo

Introduction: The use of iSGLT2 continues to be controversial in diabetic patients with peripheral arterial disease.Objectives: Assess the metabolic effect and the risk of amputations of iSGLT2 in diabetic patients cared for in the Multidisciplinary Diabetic Foot Unit (MDFU) compared to a control group.Material and Methods: A retrospective observational study where patients attended at the MDFU from December 2017 to January 2020 we...