Endocrine Abstracts

Introduction: Craniofacial fibrous dysplasia, characteristic of McCune-Albright syndrome (MAS), is usually present in patients with MAS related GH excess, and complicates their neurosurgical approach. We describe a 21-year-old male with severe craniofacial fibrous dysplasia and acute obstructive hydrocephalus due to a 39×35 mm cystic lesion in the third ventricle that occluded Monro’s foramina, in whom MAS and long-term untreated acromegaly were discovered.<p cla...

Introduction: Amiodarone-induced thyrotoxicosis (AIT) can present a high morbi-mortality.Initial subtype identification facilitates appropriate management.We describe the utility of diagnostic tests in a cohort of patients with AIT.Material and methods: Retrospective, observational study of 59 patients attended from 2007 to 2018 in outpatient clinic. Differential diagnosis: type I if FT4 and FT3 (TH) were normalized following therapy with antithyroid dru...

Anaplastic thyroid cancer (ATC) is usually treated with surgery, external hyperfractionated radiation therapy, and chemotherapy. However, because of the aggressiveness of this type of cancer, these treatments allow about 6-10 months of median survival. Therefore, it is challenging to predict the ATC patient clinical therapy responsiveness. Pazopanib is a multitarget tyrosine kinase inhibitor of VEGF receptors, PDGF, and c-Kit, and its effect in primary human ATC cells (pATC) h...

Background: Peptide receptor radionuclide therapy (PRRT) was introduced in 2018 as one of the major advances in treatment of patients with neuroendocrine neoplasms (NENs). Initial results from the NETTER-1 trial suggested a very low percentage of secondary hematological malignancies, including myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML). We sought to confirm that data in a large institutional database. Methods: Under an institutio...

Introduction: Autoimmune thyroid diseases (AITD) such as Graves’ disease (GD) or Hashimoto’s thyroiditis (HT) are autoimmune, organ-specific diseases probably related to a complex and multifactorial interplay of specific susceptibility genes and environmental exposures. T lymphocytes and their secretory cytokines play indispensable roles in disrupting tolerance. However, their roles are often complex and full of interactions among distinct components of the thyroid e...

Context: Pathological transcriptomic landscape has been the driver of the Molecular Biology in the recent years. Massive RNA sequencing techniques have been extended from bulk RNAseq, to single cell sequencing (scRNAseq) and spot-based spatial transcriptomics (ST), and sometimes laboratory cannot afford all of them. We tried to answer the question about which would be the best option in thyroid gland using Hashimoto’s thyroiditis (HT) context.Method...

Introduction: The escalating prevalence of obesity worldwide increases the risk of chronic diseases and diminishes life expectancy with growing economic burden necessitating intervention. The existing tiered approach to weight management, particularly specialist Tier 3 services, falls short of meeting the population’s needs. The emergence of digital health tools, while promising, lacks exploration in specialized NHS weight management services (WMS)....

Introduction: Nutritional status in patients with neuroendocrine tumors (NETs), especially with gastroenteropancreatic origin, may be affected and have an impact on prognosis and survival. Different techniques are currently available to assess nutritional status, but not all of them are accessible in routine clinical practice. In this context, Body composition of NET patients was calculated by computed tomography (CT) at L3 level to evaluate its importance on clinical prognosi...

Objective: Various features have been identified as predictors of relapse after complete resection of pheochromocytoma, but a comprehensive multivariable model for recurrence risk prediction is lacking. The aim of this study was to develop and internally validate an integrated predictive model for post-surgical recurrence of pheochromocytoma.Methods: The present research retrospectively enrolled 177 patients affected by pheochromocytoma and submitted to ...

Background and Objective: Gestational Diabetes Mellitus (GDM) is associated with life-long adverse outcomes for the mother and the baby. To date there is no rigorous clinical test for the assessment of GDM risk, since estimation of GDM risk is currently primarily based on clinical risk factors. Additional markers are needed to identify women at high risk. Our aim was to develop and validate a risk assessment model to identify women at high risk of GDM through an algorithm that...