Endocrine Abstracts

Background: Patients with acromegaly have an increased risk of vertebral fractures, yet normal or elevated bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA). This suggests that DXA may not be a reliable tool for assessing BMD in acromegalic patients. Multiple studies have suggested that patients with acromegaly have compromised trabecular bone but not cortical bone. Quantitative computed tomography (QCT) represents a three-dimensional technique for quantifyi...

Objective: Recently rare heterozogous AMH genetic variants have been identified in women with polycystic ovary syndrome (PCOS) that result in reduced AMH signaling. However, the exact functional mechanism remains unknown. Therefore, we have performed functional analyses to analyze the processing, secretion and signaling of these PCOS-specific AMH rare variants.Methods: Six PCOS-specific AMH variants containing mutations (V12G, P151S, P270S, P352S, P362S,...

Mesenchymal stem cell (MSC), as a significant part of regenerative medicine, has been considered as a promising therapy in several diseases. Recently, the secretion effect of MSCs has been found to play a key role in the regulation of inflammatory. Here, we screened different peptides with high expression abundance by mass spectrometry from the supernatant of human umbilical cord MSCs. Also, we identified a peptide (AQTKRLVGDVLLATAFLSYSGP) named MSC-P2 derived from dynein axon...

A 31-year-old man originally from Ukraine attended the clinic having been started on Carbimazole 20 mg by his GP. His symptoms included intermittent palpitations, sweating and poor sleep and they had improved since starting anti-thyroid therapy. He was originally diagnosed with thyrotoxicosis in Germany in 1999 but was not treated and he re-presented in 2005. This time he was started on Carbimazole but stopped treatment on his own accord after a month because his symptoms impr...

A 60 year old lady was diagnosed with thyrotoxicosis in 1985 (aged 28) five months postpartum. She underwent partial thyroidectomy in 1990 (age 32). Thyroid tests remained abnormal and in 1992, she underwent radio-iodine treatment requiring post-treatment. She remained under endocrine supervision and the TSH was found to be persistently elevated with normal free thyroid hormone levels (whilst on Levothyroxine). Issue with compliance and assay interference were considered. She ...

Background: Cardiovascular disease (CVD) is a serious complication of diabetes mellitus (DM) and is associated with considerable morbidity and high mortality. There is increasing evidence to suggest that dysregulation of the epigenome is involved in diabetes and CVD.Objective: To assessed the alteration of DNA methylation in patients with/without diabetes but developed CVD in a cohort study of Chinese patients.Methods: 40 patients ...

Polycystic ovary syndrome (PCOS) is a significant risk factor for the development and progression of type I endometrial cancer (EC). Currently, it is not known whether metformin has a direct effect on the endometria and further regulates glycolysis and mitochondrial function in PCOS patients with endometrial hyperplasia and carcinoma. Here we show that endometria from PCOS patients with endometrial hyperplasia and carcinoma have a distinct protein expression pattern of glycoly...

Introduction: Chemerin is a pro-inflammatory adipokine, which has been shown as a mediator between obesity and metabolic syndrome (MetS). The aim of this study was to evaluate the associations of chemerin with insulin resistance and the effects of lifestyle interventions on circulating chemerin levels in Chinese obese children.Methods: A cross-sectional study was conducted among 225 obese children (101 with MetS and 124 without MetS) and 119 lean control...

Increased deposition of extracellular matrix (ECM) components such as collagens and hyaluronan is associated with diet-induced insulin resistance (IR) in skeletal muscle. Studies of the role of specific ECM components in muscle IR have been pivotal but incomplete. Here we used an approach (i.e. ECM-specific mass spectrometry-based proteomics) that gives a more complete view of ECM protein abundance with muscle IR. Male C57BL/6 mice were fed with either a chow or high fat (HF) ...

Background: We have previously investigated the association between serum ferritin levels and risks of metabolic syndrome (MetS) using the same database from 2009 wave of the China Health and Nutrition Survey (2009 CHNS). We confirmed that MetS components are associated with increased serum ferritin levels in both men and women group, included abdominal obesity, hypertriglyceridemia, low HDL cholesterol, high blood pressure, and abnormal glucose level. Although, the prevalence...