Endocrine Abstracts

Aim: Postoperative hypocalcemia is seen in 26-42% patients after parathyroidectomy.There are quite a lot of studies investigating preoperative factors that might be used to predict postoperative hypocalcemia in thyroidectomized patients, however there are less studies in parathyroidectomized patients.In this study, our aim was to determine whether any preoperative clinical, laboratory or ultrasonographical feature anticipate hypocalcemia in parathyroidectomized patients due to...

Polycystic Ovary Syndrome (PCOS) is an endocrine disorder affecting 10-15% of women worldwide, characterized by high androgen levels, anovulation and/or polycystic ovarian morphology. Chronic low-grade inflammation is associated with the disorder as well as many of its comorbidities, such as obesity and type-2 diabetes. To determine the role of the immune system in the pathophysiology of PCOS, we characterized the immune profile of the dihydrotestosterone (DHT)-induced PCOS-li...

Introduction: Graves disease (GD) is an autoimmune disease in which thyrotropin receptor antibodies overactive the thyroid gland. Therefore, antithyroid drugs, radioactive iodine therapy, or surgical interventions are treatment options. In GD, pathology after thyroidectomy may include hypertrophy and hyperplasia in thyrocytes, mononuclear cell infiltration in the stroma, and increased blood supply. We presented a case with areas of necrosis and vasculitis due to GD in the path...

The majority of the body’s 5-HT (serotonin) is produced from enterochromaffin cells (ECs) of the intestinal epithelium. 5-HT has important roles within the gastrointestinal tract in the modulation of motility, secretion and inflammation, while also signalling satiety and discomfort to the central nervous system. The factors regulating release of 5-HT from human small intestinal ECs have not been clearly elucidated: although circulating 5-HT levels typically increase after...

Aim: It is hypotethically thought that increased frequency of breast cancer in patients with primary hyperparathyroidism(PHPT)may be due to the fact that calcium accumulation in the breast may be higher in patients with PHPT giving rise to more breast-related examinations. Although there are many studies or case reports showing calcification in many organs and tissues, in PHPT, there is not any study investigating breast calcification in these patients in the literature. We ai...

Introduction: Radioiodine-resistant thyroid carcinoma is an important milestone in the treatment and follow-up of thyroid cancers. The biological defects of iodine uptake in thyroid cancer cells should be well known. In this study, we aimed to evaluate the clinical and pathological features and SLC5A5 gene expression status of iodine-refractory papillary thyroid carcinoma patients. Material-Method: We studied SLC5A5 expression in 83 papillary thyroid car...

Introduction: The incidence of papillary thyroid cancer (PTC) in the coexistence of Graves’ disease (GD) and thyroid nodule is not known clearly, and the pathophysiology of PTC development in these patients is still unclear. Aim: The aim of our study is to compare the clinicopathological features of GD patients with thyroid nodule + PTC and patients with euthyroid and non auto-immune thyroid nodule + PTC and investigate the clinicopathological featu...

White adipose tissue (WAT) is a dynamic and heterogeneous organ composed of different cell types involved in a wide array of biological processes. We know that women with polycystic ovary syndrome (PCOS) suffer from insulin resistance and type 2 diabetes which is associated with pathological white adipose tissue (WAT) function and expansion characterized by hypertrophic adipocytes, altered production and release of lipids and adipokines, and chronic low-grade tissue inflammati...

Background: Ectopic malignancies arising from adrenal rests are extremely rare. Localization has been reported in the retroperitoneum, testis/scrotum, ovary, kidney, anterior abdominal wall, spinal cord, and liver associated with embryological development 1-3.Objective: This report presents a case of ectopic adrenocortical cancer (ACC) localized to the pancreas. An exciting feature of the case was the simultaneous presence of breast cancer.</p...

Background: Adrenal incidentalomas are defined as clinically silent adrenal masses >1 cm in size and are detected in up to 10% of patients during imaging procedures performed for unrelated conditions. 17% and 23% of incidentally detected adrenal lesions were reported to be bilateral. The bilateral adrenal tumors include metastasis, lymphoma, neuroblastoma, pheochromocytoma, adenoma and myelolipoma. Non-neoplastic bilateral adrenal masses include infectious processes and he...