Endocrine Abstracts

Introduction: There are a few hypothyroid patients who are refractory to standard thyroid hormone replacement treatment and require unexpectedly high doses of levothyroxine. In addition to clinical situations where hypothyroid patients are non-compliant (pseudomalbsortion), or where there is the possibility of excipient-induced disease exacerbation, therapeutic failure may be due to impaired absorption of the administered drug. The common approach to managing patients is to es...

Introduction: The autoimmune polyglandular syndrome (APS) is a complex, heterogeneous condition in which autoimmune diseases (AIs) of endocrine and non-endocrine organs can occur. There are four subgroups. The majority of patients are categorized as having APS II or APS III. In APS II, patients have Addison’s disease (AD) and autoimmune thyroid diseases (AITDs) or type I. diabetes mellitus (T1DM), while in the APS III, AITDs are combined with other autoimmune illnesses ex...

Background: Somatostatin analogues are the mainstay medical treatment of acromegaly. Side effect of this treatment includes gastrointestinal disturbances, cholelithiasis, and local reactions at injection sites. Herein we report an unusual case of local myofascitis after one-year treatment with deep subcutaneous injections of lanreotide Autogel in a patient with acromegalo-gigantism.Clinical case: A 25-year-old man was found to have an invasive macroadeno...

In the late years ISGLT2 have became an usual choice to treat diabetes. The inhibition of the sodium-glucose co transporters (SLGT2) inhibits also the glucose reabsorption in the proximale tubule and increases the glucose excreted in the urine. Therefore hyperglycemia decreases and so does weight. This is a very convenient side effect since type 2 DM is highly associated with overweight/obesity. We show the results of HbA1c and weight evolution after starting canaglifozina 100...

: White adipose tissue (WAT) has an important role in the regulation of metabolic homeostasis. It is well known that two distinct WAT depots in mammals, subcutaneous WAT (sWAT) and visceral WAT (vWAT) display different metabolic roles and it could be presumed that exert different response to various hormones. Numerous studies revealed leading role of insulin in both fat accumulation (lipogenesis) and adipocyte differentiation (adipogenesis) although it is not clear is there a ...

Introduction: Brain-derived neurotrophic factor (BDNF) is a protein that has been linked to several cardiovascular risk factors and bone status. Stress and corticosteroid exposure can affect BDNF levels, although this has never been studied in Cushing’s syndrome (CS). The aims of this study were to establish if BDNF levels were reduced in CS and to check possible associations to cardiovascular risk factors and bone status.Methods: 52 patients (18 ac...

Introduction: Acromegaly is associated with increased bone turnover and skeletal fragility. Although the GH/IGF1 system plays an important role in bone homeostasis, effects of GH excess on the Wnt signalling pathway are to be determined. Bone quantitative CT (QCT) provides a volumetric, tridimensional measure of bone mass at the trabecular and cortical level.Aim: i) To compare volumetric bone density (vBMD) using QCT in patients with acromegaly vs gender...

The 46 XX male syndrome (de la Chapelle syndrome or 46,XX testicular disorder of sex development -46,XX testicular DSD-) is a rare phenotype associated with disorder of the sex chromosomes. XX males exist in different clinical categories with ambiguous genitalia or partially to fully mature male genitalia, in combination with complete or incomplete masculinization.Clinical report: We describe the clinical, molecular, and cytogenetic findings of a 26-year...

Adipose tissue distribution is one of the key determinants of metabolic dysfunction in obesity. Several large scale studies found that enlarged neck circumference is independently associated with cardiovascular risk.The aim of this study was to examine the association of neck circumference with metabolic risk factors in patients undergoing neck surgery.In 36 patients undergoing thyroid or vascular neck surgery we determined serum l...

Objective: To evaluate the effects of GH on cardiac structure and function of patients with panhypopituitarism.Material and methods: We performed echocardiographic studies of patients with panhypopituitarism treated and not treated with GH at baseline and after 12 years of follow up. We collected clinical and echocardiographic data (systolic and diastolic ventricular diameter (LVEDD and DTSVI), interventricular septum thickness (IVS), left ventricular po...