Endocrine Abstracts

Introduction: Sarcopenia, an age-associated loss of skeletal muscle mass and function, has been related to higher mortality in general population as well as in HIV-infected patients. In elderly, sarcopenia is a marker of frailty. The aim of our study was to describe the prevalence of sarcopenia and related factors in HIV-infected population.Methods: Skeletal muscle mass (SMM), total fat mass and body fat distribution were measured by DXA scan. Muscle mas...

Pancreatic neuroendocrine tumors (panNETs) are the second most common neoplasm of the pancreas. panNETs arise from cells of the pancreatic islets and comprise a diverse and heterogeneous group of neoplasms. This hampers their systematic study, and the identification of common molecular signatures that might facilitate a better diagnosis of the disease, and the development of efficient therapeutic approaches. Indeed, there are no clinical, biochemical, anatomopathological, immu...

IntroductionTP53 mutations have been rarely reported in pituitary tumours. Recently two exploratory exome sequencing studies have identified somatic TP53 mutations in a small number of functional corticotroph tumours (6/18 and 4/10) with USP8 wild type (wt) status, suggesting that they may be more frequent than previously thought. Nevertheless, the clinical impact of those mutations is still unknown.AimTo det...

Introduction and Objectives: The tolerance of extended-release metformin (XRM) is superior to that of conventional metformin. XRM is recently available in Spain as a fixed combination with sitagliptin, but not in monotherapy. There are no data yet on how additional antidiabetic treatment can modify the effects of the XRM/sitagliptin combination. After assessing the efficacy and tolerability of XRM/sitagliptin in patients with T2DM labelled as metformin-intolerant and treated w...

Introduction and Objective: Extended-release metformin has much better gastrointestinal tolerability than conventional (immediate release)metformin and according to the UK NICE guidelines should be offered to patients who have gastrointestinal tolerance issues with conventional metformin. We rechallenged patients with T2DM labelled as metformin-intolerant and treated with a DPP4i with a single-pill combination (SPC) of extended release metformin and sitagliptin (1000/50 mg) in...

Introduction and Objectives: The tolerability of extended-release metformin (XRM) is clearly superior to that of conventional metformin, with the potential to improve patient compliance, effectiveness and outcomes. Since 2005 the NICE guidelines for type 2 diabetes mellitus (T2DM) recommend its use in patients with metformin-caused gastrointestinal disturbances. XRM is recently available in Spain as a fixed combination with sitagliptin, but not in monotherapy. We assessed the ...

Low plasma sex hormone-binding globulin (SHBG) levels are present in fatty liver disease, which represent a spectrum of diseases ranging from hepatocellular steatosis through steatohepatitis to fibrosis and irreversible cirrhosis. We have previously determined that fat accumulation reduces SHBG production in different non-alcoholic fatty liver disease (NAFLD) mouse models and that SHBG plays an active role in the development of this disease. In the present work, we are interes...

Introduction: For the clinical diagnosis of heterozygous familial hypercholesterolemia (HeFH) validated algorithms are used, with the Dutch Lipid Clinic Network (DLCN) Criteria being the most recommended in our environment. One of the items that scores for the system proposed by the DLCN is the value of LDL cholesterol. However, LDLc levels can be distorted by lipoprotein a (Lpa(a)) levels.Objective: To analyze the change in the validity of the DLCN crit...

Objective: Adrenal venous sampling (AVP) is a reliable procedure to differentiate if in patients with primary aldosteronism (PA) aldosterone production is unilateral or bilateral and guide the treatment of these patients. Our objective was to describe their characteristics and the outcomes of the AVPs.Methods and patients: Observational longitudinal clinical study between July 2020 and September 2021 in patients who underwent AVP in our Hospital.<p c...

Introduction: Obesity is one of the most important problems worldwide in recent times. Groupal lifestyle intervention programmes are efficacious in the management of obesity. While exercise and healthy dietary habits have consistently been shown to improve various metabolic markers, adherence to these behaviors is low and methods that increase adherence to health behaviors are needed.Objective: The primary objective of this study is to evaluate the effec...