Endocrine Abstracts

Introduction: Hyponatremia is the most common electrolyte imbalance among hospitalised patients. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is considered the most frequent etiology on patients with euvolemic hiponatremia. Conventional treatment includes water restriction and salt tablets with limited efficacy and very slow onset of action in certain patients.Material and methods: Systematic sampling of all SIADH patients treated wit...

The clinical significance and potential morbidity of papillary thyroid microcarcinomas (PTMC) is discussed. Particularly the differences between those PTMC identified postoperatively in histological examination (incidentals), and those diagnosed preoperatively (non-incidentals). We retrospectively analysed differences in clinical presentation and course after treatment in these two groups. The study population consisted of 199 patients with PTMC who underwent surgery from 2000...

Introduction: BRAF(V600E) mutation has received great attention to improve risk stratification in patients with PTC. Its prognostic value in the different Cytological variants (CytV) of PTC is not well established. The aim of this study was to investigate differences in clinicopathological features according to CytV, among patients harbouring the mutation.Methods: We evaluated 102 patients with pathological diagnosis of PTC. All of them underwent total t...

Introduction: We introduce a case involving the appearance of superior vena cava syndrome secondary to intrathoracic goitre. We discuss the diagnosis, prognosis and treatment applied to this pathology.Case report: A 67-year-old woman who presents respiratory distress, cough, and weight loss. After physical examination and a chest radiography showing a mass that occupied the upper and middle right lung lobes, a neoplasm is suspected and at first, palliati...

Introduction: The syndrome of late-onset hypogonadism (LOH) is a clinical and biochemical syndrome associated with advancing age male, characterized by typical symptoms and decreased serum concentrations of testosterone, which can affect multiple organ systems and may impair quality of life. The prevalence of LOH syndrome is higher in certain patient groups, obese, diabetic and suffering from erectile dysfunction manifest LOH at higher rates than the general population.<p ...

Thyrotropin-secreting pituitary tumors are <1% of pituitary adenomas. Clinical manifestations are similar to other forms of hyperthyroidism. Most of them are diagnosed as macroadenoma (microadenomas <10%).Case 1: A 48 years old woman with menopause presented 6 years ago, consulting in 2009 for weight loss and palpitations. She had elastic goiter and distal tremor. Blood test: TSH 8.66 μUI/ml (0.2–4.2), FT4 4.7 ng/dl (0.7&#150...

Objectives: Prognosis of differentiated thyroid carcinoma (DTC) is usually good, but even so a proportion of the patients develop recurrences and eventually die of the disease. The aim of this study was to analyze the clinical and histopathological features of patients with DTC in our center and to identify prognostic factors in this group of patients.Patients and methods: We reviewed, retrospectively, 213 patients (184 females and 29 males, mean age 48....

Polycystic ovary syndrome (PCOS) is an important metabolic and reproductive disorder which confers substantially increased risk for type two diabetes and metabolic syndrome (MS). Our aim is to characterize the metabolic profile, insulin sensitivity (IS) and insulin secretion in control (Cw) and PCOS women (PCOSw) during different stages of reproductive life (S1: 18–35 years old, S2: 36–44 years old, S3: 45–55 years old). A total of 131 Cw and 129 PCOSw were incl...

Introduction: During a normal menstrual cycle, serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), and progesterone (P4) can vary widely between cycles for the same woman, as well as between different women. Reliable reference values based on the local population are important for correct interpretation of laboratory results.Aims: To evaluate the discrepancy of the results on fertility hormones by two different t...

Introduction: Sleep disordered breathing (SDB) promotes structural myocardial changes and can trigger cardiac arrhythmias. Acromegalic patients have high prevalence of SDB and GH–IGF1 excess is related to a specific cardiomyopathy characterized by concentric cardiac hypertrophy and diastolic dysfunction. The aim of this study was to assess the relationship between SDB and cardiac dysfunction on acromegalic patients.Material and methods: Observationa...