Endocrine Abstracts

Androgen deficiency in the aging male has become an actual topic due to the aging population and finding from different studies that shown a progressive decline of serum levels of age-related testosterone. These levels have been inversely related with markers of metabolic syndrome and cardiovascular disease.The aim of this observational study was to investigate the relation of endogenous testosterone and other sex hormones with different components of me...

Objective: Describe a case of a patient diagnosed with papillary thyroid carcinoma by a retropharyngeal tumor.Methods: A 46-year-old male was referred from the otorhinolaryngology consult to our department with the post-operative diagnosis of papillary thyroid carcinoma, with 6 months history of upper airway dyspnea and dysphagia to solids. Physical examination: right side adenopathies, not painful on palpation. No goitre. Laryngoscopy: hypertrophy of ri...

Fine-needle aspiration cytology (FNAC) remains the mainstay in the study of thyroid nodules, with cytologic adequate specimens in almost 85% of cases in expert hands. Apart from the limitation of inadequate samples, there are false negative diagnoses in some cases, particularly in larger (>3 cm) nodules. Considering this, Large-needle biopsy (LNB) could be useful to improve diagnostic precision. We review the pathology reports (PR) of more than 100 patients operated since ...

Background: Erectile dysfunction (ED) is an increasingly recognized condition among HIV-infected, however its prevalence and etiology remain unclear. Our aim was to asses prevalence and risk factors associated to ED in this population.Methods: A cross-sectional study was performed, 88 male HIV-positive without hepatitis C or diabetes were studied. Patients were classified according antiretroviral treatment (ART): naïve, protease inhibitor (PI)-conta...

Introduction: Characteristically the discordant thyroid function test has been attributed to TSH-producing hypophyseal adenoma, familial dysalbuminemic hyperthyroxinemia and thyroid hormone resistance syndrome. We presented 2 cases with raised peripheral thyroid hormones with detectable TSH due to the presence of auto-antibodies against the peripheral thyroid hormones (PTAAb). <thead valign="...

DNA methylation is an epigenetic mechanism of gene regulation that can be modified during intrauterine and postnatal life. Pregnant women with polycystic ovary syndrome (PCOS) present elevated androgen and insulin levels, which can affect the DNA methylation pattern of their offspring. Then, we studied the global DNA methylation pattern (GDNAm) in daughters and sons born to PCOS women compared to controls. Daughters (99 born to PCOS and 87 born to control women) and sons (74 b...

The tumorigenesis of Cushing’s disease is characterized by somatic mutations in the USP8 gene in almost half of the cases. USP8 encodes for ubiquitin specific protease 8, a deubiquitinase that rescues proteins involved in the regulation of ACTH synthesis in corticotroph cells. In the present study we tested the antisecretory and antiproliferative efficacy of a commercially available specific USP8 inhibitor (IC50 3.1 μM USP8; >90 μM USP7) in immortalized muri...

Introduction: Diabetes mellitus is associated with an increased risk of osteoporotic fractures, which leads to an increased risk of disability and frailty.Aims: To assess the prevalence of frailty in type 2 diabetes and to analyze the relationship with bone mineral density (BMD) and Trabecular Bone Score (TBS), fracture risk and prevalent fractures.Methods: We carried out a cross-sectional study of 75 diabetic patients (65±7 y...

Background: The complex involvement of multiple metabolic defects in the pathogenesis of type 2 diabetes mellitus (T2DM) makes difficult the treatment in monotherapy, therefore, the use of different antidiabetic drugs with different and complementary mechanisms of action could result in better glycemic control with favorable metabolic changes.Objective: To determine the effectiveness and safety of the addition of a sodium-glucose co-transporter type 2 in...

Objective: To evaluate the effectiveness and security of bariatric surgery in metabolically healthy obese (MHO).Methods: A retrospective study of a cohort of all obese patients who underwent to bariatric surgery with a minimum two-year follow-up. Databases of all demographic, anthropometric and metabolic characteristics have been collected since 2007. Patients undergoing two surgeries were excluded. We defined as MHO patients those without diagnosis of d...