Endocrine Abstracts

Introduction: Nivolumab is an anti-programmed cell death-1 monoclonal antibody approved for the treatment of metastatic malignant melanoma. Several endocrine disorders have been reported as immune-related adverse effects. However, nivolumab-induced hypophysitis has a lower incidence than ipililumab.Case report: A 69-years old man with metastatic melanoma started to receive nivolumab. Ten weeks after the first cycle of nivolumab he presented hyperthyroidi...

Introduction: Thyroid cancer is the most common endocrine neoplasia, being its papirally version the most frequent. (90% of all differentiated thyroid neoplasms). It is usually multifocal and metastasizes normally to regional lymph nodes.Objectives: To describe the prevalence of thyroid cancer and its histopathological variants in the different regions of the province of Malaga.Material and methods: We performed a retrospective des...

Introduction: Follicular Thyroid Carcinomas (FTCs) and Follicular Variant Papillary Thyroid Carcinomas (FVPTCs) may present absence of suspicious ultrasonography features more frequently than classic papillary carcinomas. Thus, some cases may be identified with the pattern of ‘low suspicion’ rather than intermediate or high suspicion defined in the American Thyroid Association (ATA) guidelines of 2015. These guidelines establish a size cutoff of 1.5 cm to recommend f...

The clinical condition resulting from end-organ resistance to parathormone (rPTH), caused by (epi)genetic alterations of GNAS, was termed as Pseudohypoparathyroidism (PHP). The high phenotype heterogeneity, the existence of additional clinical features such as resistance to other hormones (TSH/GHRH/gonadotropins) and Albright’s hereditary osteodystrophy (AHO), led to the distinction of specific PHP subtypes.The purpose of the present work is to prov...

Introduction: ACC is a rare tumour with a incidence of 0.7–2.0/per million, more common in women between 40 and 50 years. Can be diagnosis as a incidentaloma or for clinic of abdominal pain and autonomous o hormone secretion symptoms (Cushing syndrome and hirsutism). We present the management of a particular case of hirsutism for ACC.Case report: Sixty four year old woman referring increase hair and a deeper voice for 1 year. As personal antecedents...

Introduction and objectives: Hyperglycemia is present in about 25% of hospitalized patients. His control is common deficient. Consequently it increases the average stay, infection rates and mortality. In order to improve we present a comprehensive protocol.Methods: We developed algorithms of subcutaneous insulin therapy for non-critical patients, insulin therapy i.v. for critical patients, management of hypoglycemia, fasting situations, diabetic ketoacid...

Introduction: Hereditary phaeochromocytoma (PCC) and paraganglioma (PGL) account for 30–35% of cases and have some clinically relevant peculiarities.Material and methods: Retrospective, unicentric cohort study that included all genotyped patients (n=36, 27 with PCC and 9 with PGL) diagnosed at Hospital Clínico San Carlos (Madrid) between 1984 and 2013; 33% were germline mutation carriers (25% pseudohypoxic [PH] phenotype, 75% MAP-kinas...

Introduction: Hereditary Medullary Thyroid Cancer (MTC) accounts for 20–30% of cases and has some clinically relevant peculiarities.Material and methods: Retrospective, unicentric cohort study that included all genotyped patients with MTC (n=48) diagnosed at Hospital Clínico San Carlos (Madrid) between 1984–2013; 42% were germline mutation carriers (45% moderate risk (category MOD), 45% high risk (category H), 10% highest risk (ca...

Background: There is a clear relationship between obesity and carbohydrate metabolism alterations (CMA), such as impaired glucose tolerance (IGT) and T2D. OGTT is used for the diagnosis of those alterations, but is not performed in case of normal fasting glucose values (NFG). Moreover, BMI underestimates the diagnosis of obesity and body composition alteration can be crucial to the development of abnormal carbohydrate metabolism. This study aimed to examine the discriminating ...

The demonstration of postnatal stem cells in the adenopituitary (PSC) a few years ago has made us to redraw many of the cell biology concepts that we previously had for this gland. PSC organize in a three-dimensional structure, the niche, where they combine with other populations. How many populations cohabit in the niche, and which markers should we use to define cells associated to PSC we still do know not. However, we have advanced in the definition of a PSC as a cell co-ex...