Endocrine Abstracts

Early life events have special importance in the development and may affect the lifetime vulnerability to diseases. For correct interpretation of the long-term consequences it is crucial to understand the immediate effects. The role of vasopressin in hypothalamo-pituitary-adrenal axis regulation as well as in stress-related affective disorders is important therefore we addressed the question if the lack of this hormone will modify the perinatal stress reactivity.<p class="...

The Nuclear Receptor Subfamily 5A member, Steroidogenic Factor 1 (SF-1, Ad4BP, NR5A1), is critical for steroidogenesis, stress responses, sexual differentiation and body weight regulation in mice. Patients with rare mutations in SF-1 have confirmed its role in male sexual differentiation and adrenal response to physiological stress in humans. In contrast, Liver Receptor Homologue 1 (LRH-1, FTF, CPF, NR5A2) is involved in endoderm development, bile acid and lipid metabolism and...

In vitro 3D cell culture systems seem to appropriately reproduce the tumor cell microenvironment, including nutrients-oxygen conditions and cell-cell interactions. These models may better mimic in vivo tumor conditions and more accurately reproduce drug treatments effects. Since most in vitro studies in neuroendocrine tumors (NETs) are performed in 2D culture systems (monolayer), we aimed to compare the monolayer system with a 3D spheroid cell cultur...

Objective: Thyroid cancer (TC) screening in acromegaly is a controversial topic. The Endocrine Society opposes routine TC screening in acromegaly patients without a palpable nodule, and the American Thyroid Association does not consider acromegaly to be a high-risk condition for developing TC. However, acromegaly is associated with an increased risk of TC, and some centers opt for thyroid ultrasound screening even in the absence of palpable thyroid nodules. Being one of the su...

Purpose: Acromegalic patients carry a high burden of cardiovascular, metabolic, and neoplastic diseases, but there are limited studies focusing on morphological and functional changes in the kidneys.Methods: The data of acromegalic patients followed over a 43-year period at our center were examined for the development of chronic kidney disease (CKD), renal cysts, and urological cancers.Results: A total of 394 patients (202M/192F, m...

Introduction: Obesity represents a major public health challenge and is linked with increased risk of multiple medical conditions including atrial fibrillation (AF). We have recently published the study protocol of the ‘The Effect of complex weigHt-reducing interventiOns on rhythm control in oBese subjects wITh Atrial Fibrillation’ (HOBIT-AF) trial. Here we communicate the preliminary results with the focus on the use of smart technologies and telemedicine.<...

Objective: To analyze the remission factors of surgical treatment of acromegaly Methods: A retrospective study involving 227 patients with acromegaly: 143 (63%) women and 84 (37%) men were operated via trassphenoidal endoscopic approach for pituitary adenoma removal between the periods of 2018-2021. The average age was 45 years [36.00, 56.00]. 118 patients had 6 months follow-up period (3-40 months). The IGF-1 index used for the evaluation, which was cal...

Objectives: The activating mutation (L206R) in PRKACA has been reported in more than 30–50% of cases with cortisol-producing adenomas (CPAs). We aimed to compare the clinical characteristics and gene expression profiling between PRKACA L206R mutant and wild type CPAs.Methods: We included 57 subjects with CPAs who underwent adrenalectomy at Seoul National University Hospital. Sanger sequencing for PRKACA w...

Glucocorticoids (GC) are potent anti-inflammatory compounds, acting mainly through the glucocorticoid receptor (GR). GC therapy, however, has debilitating side-effects, necessitating safer new alternative therapies. The natural GC metabolite 5α-Tetrahydrocorticosterone (5αTHB) is anti-inflammatory in vivo in mice, but with fewer side-effects. Its mechanism of action is unknown, and here we test signalling via GR and the mineralocorticoid receptor (MR). 5&#94...

Objective: Cilostazol, a selective inhibitor of phosphodiesterase 3, which has been widely used in patients with atherosclerotic diseases, is known to have additional beneficial effects on dyslipidemia. ATP-binding cassette transporter A1 (ABCA1) plays a critical role in the regulation of intracellular cholesterol levels in hepatocytes. We aimed to investigate the effect of Cilostazol on hepatic steatosis and its underlying mechanism related to ABCA1.Met...